Compounds > etodolac, (-)-isomer
Page last updated: 2024-12-09

etodolac, (-)-isomer

Description

(R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID667528
CHEMBL ID1716091
CHEBI ID60370
SCHEMBL ID3905
MeSH IDM0329290

Synonyms (46)

Synonym
BIDD:GT0544
AB01274754-01
brn 5761989
pyrano(3,4-b)indole-1-acetic acid, 1,3,4,9-tetrahydro-1,8-diethyl-, (r)-
(-)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
(-)-etodolic acid
rak-593
[(1r)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid
(r)-(-)-etodolac
CHEBI:60370 ,
(r)-etodolac
(-)-etodolac
(-)-[1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid
848873-99-4
2-[(1r)-1,8-diethyl-4,9-dihydro-3h-pyrano[3,4-b]indol-1-yl]acetic acid
A825520
2-[(1r)-1,8-diethyl-4,9-dihydro-3h-pyrano[3,4-b]indol-1-yl]ethanoic acid
unii-y1rah31t6k
87226-41-3
r-etodolac
etodolac, (-)-
sdx 101
y1rah31t6k ,
pyrano[3,4-b]indole-1-aceticacid, 1,8-diethyl-1,3,4,9-tetrahydro-, (1r)-
S1328
pyrano(3,4-b)indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-, (r)-
(1r)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
etodolac, (r)-
(-)-(r)-etodolac
KS-1056 ,
pyrano(3,4-b)indole-1-acetic acid, 1,8-diethyl-1,3,4,9-tetrahydro-, (1r)-
147170-18-1
sdx-101
BRD-K99260425-001-01-2
SCHEMBL3905
DTXSID60233938
(r)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
NNYBQONXHNTVIJ-QGZVFWFLSA-N
CHEMBL1716091
AB01274754_02
8qs ,
NCGC00386139-01
Q27127224
HMS3884C11
CCG-267352
bdbm50589222

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
etodolacA monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
USP1 protein, partialHomo sapiens (human)Potency39.81070.031637.5844354.8130AID504865
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency39.81070.354828.065989.1251AID504847
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency12.58930.251215.843239.8107AID504327
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency39.81070.060110.745337.9330AID492961
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Catenin beta-1Homo sapiens (human)IC50 (µMol)683.00000.80007.668810.0000AID1850527
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (152)

Processvia Protein(s)Taxonomy
positive regulation of telomere maintenance via telomeraseCatenin beta-1Homo sapiens (human)
negative regulation of apoptotic processCatenin beta-1Homo sapiens (human)
positive regulation of epithelial to mesenchymal transitionCatenin beta-1Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICatenin beta-1Homo sapiens (human)
MAPK cascadeCatenin beta-1Homo sapiens (human)
protein polyubiquitinationCatenin beta-1Homo sapiens (human)
embryonic axis specificationCatenin beta-1Homo sapiens (human)
branching involved in blood vessel morphogenesisCatenin beta-1Homo sapiens (human)
osteoblast differentiationCatenin beta-1Homo sapiens (human)
branching involved in ureteric bud morphogenesisCatenin beta-1Homo sapiens (human)
in utero embryonic developmentCatenin beta-1Homo sapiens (human)
gastrulation with mouth forming secondCatenin beta-1Homo sapiens (human)
cell fate specificationCatenin beta-1Homo sapiens (human)
endodermal cell fate commitmentCatenin beta-1Homo sapiens (human)
neuron migrationCatenin beta-1Homo sapiens (human)
epithelial to mesenchymal transitionCatenin beta-1Homo sapiens (human)
neural plate developmentCatenin beta-1Homo sapiens (human)
positive regulation of neuroblast proliferationCatenin beta-1Homo sapiens (human)
positive regulation of mesenchymal cell proliferationCatenin beta-1Homo sapiens (human)
chondrocyte differentiationCatenin beta-1Homo sapiens (human)
lens morphogenesis in camera-type eyeCatenin beta-1Homo sapiens (human)
outflow tract morphogenesisCatenin beta-1Homo sapiens (human)
regulation of secondary heart field cardioblast proliferationCatenin beta-1Homo sapiens (human)
metanephros morphogenesisCatenin beta-1Homo sapiens (human)
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisCatenin beta-1Homo sapiens (human)
transcription by RNA polymerase IICatenin beta-1Homo sapiens (human)
cell adhesionCatenin beta-1Homo sapiens (human)
cell-matrix adhesionCatenin beta-1Homo sapiens (human)
chemical synaptic transmissionCatenin beta-1Homo sapiens (human)
ectoderm developmentCatenin beta-1Homo sapiens (human)
glial cell fate determinationCatenin beta-1Homo sapiens (human)
neuroblast proliferationCatenin beta-1Homo sapiens (human)
positive regulation of cell population proliferationCatenin beta-1Homo sapiens (human)
negative regulation of cell population proliferationCatenin beta-1Homo sapiens (human)
fibroblast growth factor receptor signaling pathwayCatenin beta-1Homo sapiens (human)
response to xenobiotic stimulusCatenin beta-1Homo sapiens (human)
anterior/posterior axis specificationCatenin beta-1Homo sapiens (human)
dorsal/ventral axis specificationCatenin beta-1Homo sapiens (human)
proximal/distal pattern formationCatenin beta-1Homo sapiens (human)
positive regulation of gene expressionCatenin beta-1Homo sapiens (human)
negative regulation of gene expressionCatenin beta-1Homo sapiens (human)
positive regulation of epithelial to mesenchymal transitionCatenin beta-1Homo sapiens (human)
positive regulation of heparan sulfate proteoglycan biosynthetic processCatenin beta-1Homo sapiens (human)
negative regulation of angiogenesisCatenin beta-1Homo sapiens (human)
stem cell population maintenanceCatenin beta-1Homo sapiens (human)
layer formation in cerebral cortexCatenin beta-1Homo sapiens (human)
hypothalamus developmentCatenin beta-1Homo sapiens (human)
central nervous system vasculogenesisCatenin beta-1Homo sapiens (human)
osteoclast differentiationCatenin beta-1Homo sapiens (human)
male genitalia developmentCatenin beta-1Homo sapiens (human)
hindbrain developmentCatenin beta-1Homo sapiens (human)
regulation of centriole-centriole cohesionCatenin beta-1Homo sapiens (human)
pancreas developmentCatenin beta-1Homo sapiens (human)
hair follicle morphogenesisCatenin beta-1Homo sapiens (human)
regulation of protein ubiquitinationCatenin beta-1Homo sapiens (human)
regulation of myelinationCatenin beta-1Homo sapiens (human)
negative regulation of chondrocyte differentiationCatenin beta-1Homo sapiens (human)
response to estradiolCatenin beta-1Homo sapiens (human)
positive regulation of transcription elongation by RNA polymerase IICatenin beta-1Homo sapiens (human)
T cell differentiation in thymusCatenin beta-1Homo sapiens (human)
negative regulation of protein sumoylationCatenin beta-1Homo sapiens (human)
adherens junction assemblyCatenin beta-1Homo sapiens (human)
protein localization to cell surfaceCatenin beta-1Homo sapiens (human)
embryonic heart tube developmentCatenin beta-1Homo sapiens (human)
genitalia morphogenesisCatenin beta-1Homo sapiens (human)
embryonic forelimb morphogenesisCatenin beta-1Homo sapiens (human)
embryonic hindlimb morphogenesisCatenin beta-1Homo sapiens (human)
hair cell differentiationCatenin beta-1Homo sapiens (human)
detection of muscle stretchCatenin beta-1Homo sapiens (human)
embryonic skeletal limb joint morphogenesisCatenin beta-1Homo sapiens (human)
astrocyte-dopaminergic neuron signalingCatenin beta-1Homo sapiens (human)
regulation of T cell proliferationCatenin beta-1Homo sapiens (human)
odontogenesis of dentin-containing toothCatenin beta-1Homo sapiens (human)
embryonic digit morphogenesisCatenin beta-1Homo sapiens (human)
positive regulation of apoptotic processCatenin beta-1Homo sapiens (human)
negative regulation of apoptotic processCatenin beta-1Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic processCatenin beta-1Homo sapiens (human)
positive regulation of MAPK cascadeCatenin beta-1Homo sapiens (human)
positive regulation of neuron apoptotic processCatenin beta-1Homo sapiens (human)
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiationCatenin beta-1Homo sapiens (human)
bone resorptionCatenin beta-1Homo sapiens (human)
positive regulation of cell differentiationCatenin beta-1Homo sapiens (human)
positive regulation of endothelial cell differentiationCatenin beta-1Homo sapiens (human)
positive regulation of osteoblast differentiationCatenin beta-1Homo sapiens (human)
negative regulation of osteoclast differentiationCatenin beta-1Homo sapiens (human)
positive regulation of fibroblast growth factor receptor signaling pathwayCatenin beta-1Homo sapiens (human)
regulation of angiogenesisCatenin beta-1Homo sapiens (human)
negative regulation of DNA-templated transcriptionCatenin beta-1Homo sapiens (human)
positive regulation of DNA-templated transcriptionCatenin beta-1Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICatenin beta-1Homo sapiens (human)
negative regulation of mitotic cell cycle, embryonicCatenin beta-1Homo sapiens (human)
regulation of fibroblast proliferationCatenin beta-1Homo sapiens (human)
cell maturationCatenin beta-1Homo sapiens (human)
synaptic vesicle transportCatenin beta-1Homo sapiens (human)
thymus developmentCatenin beta-1Homo sapiens (human)
oocyte developmentCatenin beta-1Homo sapiens (human)
embryonic foregut morphogenesisCatenin beta-1Homo sapiens (human)
positive regulation of skeletal muscle tissue developmentCatenin beta-1Homo sapiens (human)
regulation of smooth muscle cell proliferationCatenin beta-1Homo sapiens (human)
neuron fate determinationCatenin beta-1Homo sapiens (human)
oligodendrocyte differentiationCatenin beta-1Homo sapiens (human)
negative regulation of oligodendrocyte differentiationCatenin beta-1Homo sapiens (human)
regulation of neurogenesisCatenin beta-1Homo sapiens (human)
synapse organizationCatenin beta-1Homo sapiens (human)
smooth muscle cell differentiationCatenin beta-1Homo sapiens (human)
myoblast proliferationCatenin beta-1Homo sapiens (human)
regulation of timing of anagenCatenin beta-1Homo sapiens (human)
regulation of synapse assemblyCatenin beta-1Homo sapiens (human)
oviduct developmentCatenin beta-1Homo sapiens (human)
canonical Wnt signaling pathwayCatenin beta-1Homo sapiens (human)
trachea formationCatenin beta-1Homo sapiens (human)
epithelial tube branching involved in lung morphogenesisCatenin beta-1Homo sapiens (human)
lung-associated mesenchyme developmentCatenin beta-1Homo sapiens (human)
lung epithelial cell differentiationCatenin beta-1Homo sapiens (human)
lung inductionCatenin beta-1Homo sapiens (human)
epithelial cell differentiation involved in prostate gland developmentCatenin beta-1Homo sapiens (human)
epithelial cell proliferation involved in prostate gland developmentCatenin beta-1Homo sapiens (human)
positive regulation of epithelial cell proliferation involved in prostate gland developmentCatenin beta-1Homo sapiens (human)
hair follicle placode formationCatenin beta-1Homo sapiens (human)
establishment of blood-brain barrierCatenin beta-1Homo sapiens (human)
mesenchymal cell proliferation involved in lung developmentCatenin beta-1Homo sapiens (human)
positive regulation of branching involved in lung morphogenesisCatenin beta-1Homo sapiens (human)
endothelial tube morphogenesisCatenin beta-1Homo sapiens (human)
fungiform papilla formationCatenin beta-1Homo sapiens (human)
sympathetic ganglion developmentCatenin beta-1Homo sapiens (human)
cranial ganglion developmentCatenin beta-1Homo sapiens (human)
regulation of centromeric sister chromatid cohesionCatenin beta-1Homo sapiens (human)
cellular response to growth factor stimulusCatenin beta-1Homo sapiens (human)
cellular response to indole-3-methanolCatenin beta-1Homo sapiens (human)
renal vesicle formationCatenin beta-1Homo sapiens (human)
renal inner medulla developmentCatenin beta-1Homo sapiens (human)
renal outer medulla developmentCatenin beta-1Homo sapiens (human)
nephron tubule formationCatenin beta-1Homo sapiens (human)
stem cell proliferationCatenin beta-1Homo sapiens (human)
regulation of nephron tubule epithelial cell differentiationCatenin beta-1Homo sapiens (human)
mesenchymal stem cell differentiationCatenin beta-1Homo sapiens (human)
negative regulation of canonical Wnt signaling pathwayCatenin beta-1Homo sapiens (human)
regulation of calcium ion importCatenin beta-1Homo sapiens (human)
acinar cell differentiationCatenin beta-1Homo sapiens (human)
synaptic vesicle clusteringCatenin beta-1Homo sapiens (human)
apoptotic signaling pathwayCatenin beta-1Homo sapiens (human)
cell-cell adhesionCatenin beta-1Homo sapiens (human)
positive regulation of odontoblast differentiationCatenin beta-1Homo sapiens (human)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwayCatenin beta-1Homo sapiens (human)
cranial skeletal system developmentCatenin beta-1Homo sapiens (human)
midbrain dopaminergic neuron differentiationCatenin beta-1Homo sapiens (human)
neuron projection extensionCatenin beta-1Homo sapiens (human)
embryonic brain developmentCatenin beta-1Homo sapiens (human)
dorsal root ganglion developmentCatenin beta-1Homo sapiens (human)
establishment of blood-retinal barrierCatenin beta-1Homo sapiens (human)
regulation of protein localization to cell surfaceCatenin beta-1Homo sapiens (human)
positive regulation of determination of dorsal identityCatenin beta-1Homo sapiens (human)
positive regulation of myoblast proliferationCatenin beta-1Homo sapiens (human)
positive regulation of stem cell proliferationCatenin beta-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (21)

Processvia Protein(s)Taxonomy
transcription coregulator bindingCatenin beta-1Homo sapiens (human)
transcription corepressor bindingCatenin beta-1Homo sapiens (human)
chromatin bindingCatenin beta-1Homo sapiens (human)
transcription coactivator activityCatenin beta-1Homo sapiens (human)
signaling receptor bindingCatenin beta-1Homo sapiens (human)
protein bindingCatenin beta-1Homo sapiens (human)
nuclear receptor bindingCatenin beta-1Homo sapiens (human)
enzyme bindingCatenin beta-1Homo sapiens (human)
kinase bindingCatenin beta-1Homo sapiens (human)
protein kinase bindingCatenin beta-1Homo sapiens (human)
nuclear estrogen receptor bindingCatenin beta-1Homo sapiens (human)
ubiquitin protein ligase bindingCatenin beta-1Homo sapiens (human)
transmembrane transporter bindingCatenin beta-1Homo sapiens (human)
alpha-catenin bindingCatenin beta-1Homo sapiens (human)
cadherin bindingCatenin beta-1Homo sapiens (human)
SMAD bindingCatenin beta-1Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCatenin beta-1Homo sapiens (human)
I-SMAD bindingCatenin beta-1Homo sapiens (human)
disordered domain specific bindingCatenin beta-1Homo sapiens (human)
DNA-binding transcription factor bindingCatenin beta-1Homo sapiens (human)
protein phosphatase bindingCatenin beta-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (44)

Processvia Protein(s)Taxonomy
spindle poleCatenin beta-1Homo sapiens (human)
nucleusCatenin beta-1Homo sapiens (human)
nucleoplasmCatenin beta-1Homo sapiens (human)
cytoplasmCatenin beta-1Homo sapiens (human)
centrosomeCatenin beta-1Homo sapiens (human)
cytosolCatenin beta-1Homo sapiens (human)
plasma membraneCatenin beta-1Homo sapiens (human)
cell-cell junctionCatenin beta-1Homo sapiens (human)
adherens junctionCatenin beta-1Homo sapiens (human)
fascia adherensCatenin beta-1Homo sapiens (human)
bicellular tight junctionCatenin beta-1Homo sapiens (human)
focal adhesionCatenin beta-1Homo sapiens (human)
cell cortexCatenin beta-1Homo sapiens (human)
membraneCatenin beta-1Homo sapiens (human)
basolateral plasma membraneCatenin beta-1Homo sapiens (human)
apicolateral plasma membraneCatenin beta-1Homo sapiens (human)
lateral plasma membraneCatenin beta-1Homo sapiens (human)
Z discCatenin beta-1Homo sapiens (human)
lamellipodiumCatenin beta-1Homo sapiens (human)
cell junctionCatenin beta-1Homo sapiens (human)
microvillus membraneCatenin beta-1Homo sapiens (human)
presynaptic membraneCatenin beta-1Homo sapiens (human)
apical part of cellCatenin beta-1Homo sapiens (human)
synapseCatenin beta-1Homo sapiens (human)
postsynaptic membraneCatenin beta-1Homo sapiens (human)
perinuclear region of cytoplasmCatenin beta-1Homo sapiens (human)
extracellular exosomeCatenin beta-1Homo sapiens (human)
cell peripheryCatenin beta-1Homo sapiens (human)
Schaffer collateral - CA1 synapseCatenin beta-1Homo sapiens (human)
presynaptic active zone cytoplasmic componentCatenin beta-1Homo sapiens (human)
glutamatergic synapseCatenin beta-1Homo sapiens (human)
postsynaptic density, intracellular componentCatenin beta-1Homo sapiens (human)
beta-catenin-TCF complexCatenin beta-1Homo sapiens (human)
euchromatinCatenin beta-1Homo sapiens (human)
transcription regulator complexCatenin beta-1Homo sapiens (human)
catenin complexCatenin beta-1Homo sapiens (human)
flotillin complexCatenin beta-1Homo sapiens (human)
beta-catenin destruction complexCatenin beta-1Homo sapiens (human)
protein-containing complexCatenin beta-1Homo sapiens (human)
protein-DNA complexCatenin beta-1Homo sapiens (human)
Scrib-APC-beta-catenin complexCatenin beta-1Homo sapiens (human)
beta-catenin-TCF7L2 complexCatenin beta-1Homo sapiens (human)
beta-catenin-ICAT complexCatenin beta-1Homo sapiens (human)
Wnt signalosomeCatenin beta-1Homo sapiens (human)
cytoplasmCatenin beta-1Homo sapiens (human)
adherens junctionCatenin beta-1Homo sapiens (human)
nucleusCatenin beta-1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1850549Thermal stabilization of wildtype beta catenin ARD (148 to 662 residues) (unknown origin) assessed as change in melting temperature at 125 uM by DSF method2022Journal of medicinal chemistry, 05-26, Volume: 65, Issue:10
Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.
AID1850528Inhibition of Tcf in HEK293 cells by TOPflash luciferase reporter assay2022Journal of medicinal chemistry, 05-26, Volume: 65, Issue:10
Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.
AID1850527Inhibition of beta catenin in HEK293 cells by TOPflash luciferase reporter assay2022Journal of medicinal chemistry, 05-26, Volume: 65, Issue:10
Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.
AID1238740Inhibition of Wnt/beta-catenin (unknown origin)2015Journal of medicinal chemistry, Aug-13, Volume: 58, Issue:15
Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347411qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (42.86)24.3611
2020's4 (57.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.48

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.48 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.56 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.48)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
salvin
salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae)		3.5110abietane diterpenoid;
carbotricyclic compound;
catechols;
monocarboxylic acid		angiogenesis modulating agent;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
food preservative;
HIV protease inhibitor;
plant metabolite
toxoflavin
toxoflavin: azapteridine antibiotic; structure. toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7.		3.5110carbonyl compound;
pyrimidotriazine		antibacterial agent;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite;
toxin;
virulence factor;
Wnt signalling inhibitor
2-phenoxybenzoic acid
phenoxybenzoic acid : An aromatic ether that is diphenyl ether in which one of the hydrogens is replaced by a carboxy group.. 2-phenoxybenzoic acid : A phenoxybenzoic acid in which the phenoxy group is ortho to the carboxy group.		3.5110phenoxybenzoic acid
cercosporin
cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants. cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora.		3.5110
ncx 4040
[no description available]		2.1110
ConditionIndicatedRelationship StrengthStudiesTrials
Congenital Zika Syndrome
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510
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