beta-catenin-TCF complex
Definition
Target type: cellularcomponent
A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]
The beta-catenin-TCF complex is a key transcriptional regulator in the Wnt signaling pathway. It is a multi-protein complex that binds to DNA and regulates the expression of target genes involved in cell growth, differentiation, and development. The cellular component of this complex can be described as follows:
**Beta-catenin:** A protein that acts as a bridge between cell adhesion molecules and the cytoskeleton. It is also a key component of the Wnt signaling pathway and is essential for the formation of the beta-catenin-TCF complex.
**TCF/LEF transcription factors:** A family of transcription factors that bind to specific DNA sequences called Wnt response elements (WREs) and regulate the expression of Wnt target genes.
**Other proteins:** The beta-catenin-TCF complex can also include other proteins that are involved in the regulation of its activity. These proteins include:
* **BCL9/BCL9L:** These proteins bind to beta-catenin and enhance its interaction with TCF/LEF.
* **Pygopus:** This protein stabilizes the interaction of the beta-catenin-TCF complex with DNA.
**Nuclear localization:** The beta-catenin-TCF complex is localized to the nucleus, where it binds to DNA and regulates gene expression.
**Cellular context:** The composition and activity of the beta-catenin-TCF complex can vary depending on the cellular context and the specific Wnt pathway involved.
In summary, the beta-catenin-TCF complex is a multi-protein complex that is essential for the regulation of Wnt target genes. Its cellular component is defined by the specific proteins that make up the complex, their interactions, and their localization within the cell.'
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Proteins (4)
| Protein | Definition | Taxonomy |
|---|---|---|
| Transcription factor 7-like 2 | A transcription factor 7-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQB0] | Homo sapiens (human) |
| Catenin beta-1 | A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222] | Homo sapiens (human) |
| Transcription factor 4 | A transcription factor 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P15884] | Homo sapiens (human) |
| B-cell CLL/lymphoma 9 protein | A B-cell CLL/lymphoma 9 protein that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00512] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| LSM-42773 | aromatic ketone | ||
| etodolac, (-)-isomer | (R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. | etodolac | |
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |