Target type: cellularcomponent
A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation. [PMID:16611247]
The Scrib-APC-beta-catenin complex is a multi-protein complex that plays a crucial role in regulating cell polarity and adhesion. This complex is localized to the apical junctional complex (AJC) of epithelial cells, a specialized structure that connects adjacent cells and maintains the integrity of epithelial tissues.
The Scrib-APC-beta-catenin complex is comprised of several key components:
1. **Scribble (Scrib):** A scaffolding protein with multiple PDZ domains that serves as a central hub for the complex. Scrib interacts with various other proteins, including components of the cytoskeleton, cell adhesion molecules, and signaling pathways.
2. **Adenomatous Polyposis Coli (APC):** A tumor suppressor protein with multiple domains that binds to beta-catenin and regulates its stability. APC is also involved in microtubule dynamics and cell migration.
3. **Beta-catenin:** A key regulator of cell-cell adhesion and Wnt signaling pathway. Beta-catenin binds to Cadherins at the AJC and also translocates to the nucleus where it activates transcription of target genes.
4. **Other proteins:** The Scrib-APC-beta-catenin complex also includes other proteins such as the transmembrane protein Lethal giant larvae (Lgl), the polarity protein Par3, and the scaffolding protein Discs large (Dlg). These proteins contribute to the overall function of the complex by regulating cytoskeleton organization, cell polarity, and signaling pathways.
The Scrib-APC-beta-catenin complex plays a critical role in maintaining cell polarity by restricting the localization of beta-catenin to the AJC. This restriction is achieved through the interaction between Scrib, APC, and beta-catenin. When the complex is disrupted, beta-catenin can accumulate in the cytoplasm and translocate to the nucleus, leading to the activation of Wnt signaling pathway and uncontrolled cell growth.
The Scrib-APC-beta-catenin complex is also involved in regulating cell adhesion by interacting with cadherin-based junctions at the AJC. This interaction is important for maintaining the integrity of epithelial tissues and preventing cell detachment.
In summary, the Scrib-APC-beta-catenin complex is a key player in maintaining cell polarity and adhesion. Its localization to the AJC of epithelial cells ensures proper organization and function of these tissues. Disruptions in the complex can lead to aberrant cell signaling and tumorigenesis.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Catenin beta-1 | A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| LSM-42773 | aromatic ketone | ||
| etodolac, (-)-isomer | (R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. | etodolac | |
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |