endodermal cell fate commitment
Definition
Target type: biologicalprocess
The cell differentiation process that results in commitment of a cell to become part of the endoderm. [GOC:go_curators, ISBN:0878932437]
Endodermal cell fate commitment is a crucial developmental process that directs the formation of the endoderm, one of the three primary germ layers in animals. The endoderm gives rise to a variety of vital organs, including the lining of the digestive tract, the respiratory system, the liver, and the pancreas. This intricate process involves a complex interplay of signaling pathways, transcription factors, and epigenetic modifications. The commitment of a cell to the endodermal lineage is typically initiated by a combination of inductive signals from neighboring tissues, often the mesoderm. These signals activate specific signaling pathways, such as the Wnt and Nodal pathways, leading to the expression of key transcription factors, including Sox17, Foxa2, and GATA4. These factors work in concert to establish the endodermal identity by regulating the expression of genes responsible for endoderm-specific functions. The endodermal progenitor cells then undergo further differentiation, giving rise to specialized cell types, such as epithelial cells lining the gut, pancreatic beta cells, and hepatocytes. This differentiation process is governed by a complex network of interactions between transcription factors, signaling pathways, and microenvironmental cues. The timing and precision of these events are crucial for proper organ development and function. Dysregulation of endodermal cell fate commitment can lead to various developmental defects and diseases.'
```
"
Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Catenin beta-1 | A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| LSM-42773 | aromatic ketone | ||
| etodolac, (-)-isomer | (R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. | etodolac | |
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |