regulation of nephron tubule epithelial cell differentiation
Definition
Target type: biologicalprocess
Any process that modulates the frequency, rate or extent of nephron tubule epithelial cell differentiation. [GOC:mtg_kidney_jan10]
Nephron tubule epithelial cell differentiation is a complex and tightly regulated process that involves a cascade of signaling pathways and transcription factors. It is essential for the proper formation and function of the kidney, which filters waste products from the blood and regulates fluid and electrolyte balance. The process begins with the commitment of undifferentiated mesenchymal cells to the nephrogenic lineage. This commitment is influenced by a variety of factors, including growth factors, such as fibroblast growth factor (FGF) and Wnt proteins, as well as transcription factors, such as Pax2 and Wt1. Once committed, these cells undergo a series of developmental steps, including epithelialization, condensation, and tubulogenesis, ultimately giving rise to the various segments of the nephron tubule.
During epithelialization, mesenchymal cells lose their migratory capacity and acquire epithelial characteristics, such as cell-cell junctions and apical-basal polarity. This process is regulated by various signaling pathways, including the Wnt, Notch, and Hedgehog pathways.
Condensation involves the aggregation of epithelial cells into tightly packed structures, forming the renal vesicles. This step is crucial for the formation of the nephron tubules and is regulated by signaling pathways like the Wnt and FGF pathways.
Tubulogenesis is the final step in nephron tubule development, where the renal vesicles elongate and differentiate into the distinct segments of the nephron. This process involves the coordinated expression of a variety of transcription factors and signaling molecules, which regulate the formation of specific cell types, such as proximal tubules, loop of Henle, distal tubules, and collecting ducts.
The differentiation of nephron tubule epithelial cells is also regulated by interactions with the surrounding stroma, which provides essential signals and support. These interactions involve signaling molecules, such as growth factors and cytokines, as well as extracellular matrix components.
The regulation of nephron tubule epithelial cell differentiation is essential for the normal function of the kidney. Disruptions in this process can lead to various kidney diseases, including polycystic kidney disease, glomerulonephritis, and renal agenesis. Therefore, understanding the molecular mechanisms underlying this process is crucial for developing novel therapies for these diseases.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Catenin beta-1 | A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| LSM-42773 | aromatic ketone | ||
| etodolac, (-)-isomer | (R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. | etodolac | |
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |