Target type: biologicalprocess
The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. [GOC:dph]
Cranial ganglia development is a complex process that involves the coordinated action of multiple signaling pathways and transcription factors. It begins during early embryogenesis, when neural crest cells, a multipotent cell population derived from the dorsal neural tube, migrate to specific locations in the developing head. These cells will give rise to the sensory neurons, glial cells, and other cell types that make up the cranial ganglia.
The formation of cranial ganglia is initiated by inductive signals from the surrounding tissues, including the ectoderm, mesoderm, and endoderm. These signals activate specific transcription factors in the neural crest cells, which in turn regulate the expression of genes involved in cell fate determination, migration, and differentiation.
One of the key signaling pathways involved in cranial ganglion development is the Wnt pathway. Wnt signaling promotes the expression of transcription factors such as Pax6 and Sox10, which are essential for the specification of neural crest cells into sensory neuron precursors.
Another important pathway is the Shh pathway, which plays a role in the patterning of the cranial ganglia along the anteroposterior axis. Shh signaling also regulates the expression of genes involved in cell survival and differentiation.
Once the neural crest cells have been specified as sensory neuron precursors, they undergo a series of differentiation steps to become mature neurons. This process involves the expression of genes that encode for proteins involved in neurotransmitter synthesis, axonal growth, and synapse formation.
The development of cranial ganglia is also regulated by a complex interplay of cell-cell interactions and extracellular matrix components. These interactions ensure that the neurons form the correct connections with their target tissues, enabling the proper functioning of the sensory systems.
Cranial ganglion development is a tightly regulated process that is essential for the formation of the sensory systems of the head. Any disruption in this process can lead to a variety of developmental defects, including hearing loss, facial paralysis, and other neurological disorders.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Catenin beta-1 | A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| LSM-42773 | aromatic ketone | ||
| etodolac, (-)-isomer | (R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. | etodolac | |
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |