nephron tubule formation

Definition

Target type: biologicalprocess

The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. [GOC:mtg_kidney_jan10]

Nephron tubule formation, a complex and precisely orchestrated process, begins during embryonic development and involves intricate interactions between various cell types and signaling pathways. The process commences with the induction of the metanephric mesenchyme, a specialized population of cells that will ultimately give rise to the nephron tubules. This induction is triggered by signals from the ureteric bud, a diverticulum of the Wolffian duct. The ureteric bud extends into the metanephric mesenchyme, branching and signaling to the surrounding mesenchymal cells. These signals promote the condensation of the metanephric mesenchyme into epithelial structures known as nephric vesicles. These vesicles then undergo a series of morphogenetic events, including elongation, folding, and branching, to form the proximal convoluted tubule, the loop of Henle, and the distal convoluted tubule. During these events, the nephric vesicle undergoes epithelial-to-mesenchymal transition (EMT), giving rise to different cell types that make up the mature nephron tubule. The formation of the glomerulus, the filtering unit of the nephron, occurs simultaneously with the development of the tubules. The glomerulus is formed by the invagination of a capillary network into the Bowman's capsule, a structure derived from the nephric vesicle. The intricate coordination of these processes results in the formation of a functional nephron, capable of filtering blood and producing urine.'
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Proteins (1)

Compounds (6)