nephron tubule formation
Definition
Target type: biologicalprocess
The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. [GOC:mtg_kidney_jan10]
Nephron tubule formation, a complex and precisely orchestrated process, begins during embryonic development and involves intricate interactions between various cell types and signaling pathways. The process commences with the induction of the metanephric mesenchyme, a specialized population of cells that will ultimately give rise to the nephron tubules. This induction is triggered by signals from the ureteric bud, a diverticulum of the Wolffian duct. The ureteric bud extends into the metanephric mesenchyme, branching and signaling to the surrounding mesenchymal cells. These signals promote the condensation of the metanephric mesenchyme into epithelial structures known as nephric vesicles. These vesicles then undergo a series of morphogenetic events, including elongation, folding, and branching, to form the proximal convoluted tubule, the loop of Henle, and the distal convoluted tubule. During these events, the nephric vesicle undergoes epithelial-to-mesenchymal transition (EMT), giving rise to different cell types that make up the mature nephron tubule. The formation of the glomerulus, the filtering unit of the nephron, occurs simultaneously with the development of the tubules. The glomerulus is formed by the invagination of a capillary network into the Bowman's capsule, a structure derived from the nephric vesicle. The intricate coordination of these processes results in the formation of a functional nephron, capable of filtering blood and producing urine.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Catenin beta-1 | A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| LSM-42773 | aromatic ketone | ||
| etodolac, (-)-isomer | (R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. | etodolac | |
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |