negative regulation of mitotic cell cycle, embryonic
Definition
Target type: biologicalprocess
Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle. [GOC:dph, GOC:go_curators, GOC:tb]
Negative regulation of mitotic cell cycle, embryonic is a crucial biological process that ensures proper control over cell division during embryonic development. It involves a complex network of molecular interactions that act to suppress or inhibit the progression of the mitotic cell cycle, thereby preventing uncontrolled cell proliferation and ensuring that cells divide at the appropriate time and place. This process is essential for the establishment of proper tissue and organ formation, and disruptions in negative regulation of mitotic cell cycle, embryonic can lead to developmental abnormalities or even cancer.
The process involves the coordinated action of various regulatory proteins and signaling pathways, which act at different stages of the cell cycle. Key components include:
1. **Cyclin-dependent kinases (CDKs)**: These enzymes are crucial for driving the cell cycle by phosphorylating target proteins. In the context of negative regulation, CDK inhibitors (CKIs) play a critical role. These inhibitors bind to and inactivate specific CDKs, preventing the progression of the cell cycle.
2. **Tumor suppressor genes**: Genes like p53 and Rb play a crucial role in regulating cell cycle progression. They act as checkpoints that monitor the integrity of DNA and cellular machinery. If errors are detected, these genes trigger cell cycle arrest, preventing the replication of damaged cells and minimizing the risk of mutations.
3. **Signaling pathways**: Numerous signaling pathways, such as the TGF-β and Wnt pathways, are involved in regulating the cell cycle. These pathways can activate or inhibit CDKs, CKIs, and other cell cycle regulators, depending on the specific signals they receive.
4. **MicroRNAs**: These small, non-coding RNA molecules can regulate gene expression by targeting mRNA transcripts. Certain microRNAs are specifically involved in negatively regulating the expression of cell cycle promoting genes, thereby contributing to the control of mitotic cell cycle progression.
The precise mechanisms of negative regulation of mitotic cell cycle, embryonic can vary depending on the specific cell type and developmental stage. However, the overarching principle is to ensure that cell division occurs in a controlled and orderly manner, contributing to the proper development and function of the organism. Disruptions in this process can have severe consequences, highlighting the importance of proper regulation of mitotic cell cycle during embryogenesis.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Catenin beta-1 | A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| salvin | salvin: a biocyclic diterpenoid; from sage and rosemary (Lamiaceae) | abietane diterpenoid; carbotricyclic compound; catechols; monocarboxylic acid | angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; food preservative; HIV protease inhibitor; plant metabolite |
| toxoflavin | toxoflavin : A pyrimidotriazine that is 1,6-dimethyl-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine with oxo groups at positions 5 and 7. toxoflavin: azapteridine antibiotic; structure | carbonyl compound; pyrimidotriazine | antibacterial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite; toxin; virulence factor; Wnt signalling inhibitor |
| cercosporin | cercosporin : An organic heterohexacyclic compound that is perylo[1,12-def][1,3]dioxepine-6,11-dione substituted by hydroxy groups at positions 5 and 12, by methoxy groups at positions 7 and 10, and by 2-hydroxypropyl groups at positions 8 and 9 (the R,R-stereoisomer). It is a phytotoxin which was first isolated from the pathogenic soybean fungus, Cercospora kikuchii and later found in multiple members of the genus Cercospora. cercosporin: phyytotoxin from Cercospora beticola Sacc; posses photodynamic action on mice, bacteria & plants | ||
| LSM-42773 | aromatic ketone | ||
| etodolac, (-)-isomer | (R)-etodolac : The R-enantiomer of etodolac. It is inactive, in contrast to the enantiomer, (S)-etodolac, which is a preferential inhibitor of cyclo-oxygenase 2 and a non-steroidal anti-inflammatory. The racemate is commonly used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. | etodolac | |
| ucn 1028 c | calphostin C: structure given in first source; isolated from Cladosporium cladosporioides |