Compounds > duocarmycin b1

Page last updated: 2024-11-12

duocarmycin b1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

duocarmycin B1: from Streptomyces sp. DO-89 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	15100413
CHEMBL ID	322666
SCHEMBL ID	19493153
MeSH ID	M0168422

Synonyms (11)

Synonym
duocarmycin b1
CHEMBL322666
124325-93-5
1h-pyrrolo(3,2-f)quinoline-2-carboxylic acid, 8-bromo-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6-((5,6,7-trimethoxy-1h-indol-2-yl)carbonyl)-, methyl ester, (2r-trans)-
niosh/jv1200000
JV12000000
duocarmycin b(sub 1)
SCHEMBL19493153
DTXSID50924782
methyl (2r,8s)-8-bromo-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1h-indole-2-carbonyl)-3,7,8,9-tetrahydropyrrolo[3,2-f]quinoline-2-carboxylate
1h-pyrrolo3,2-fquinoline-2-carboxylic acid, 8-bromo-2,3,6,7,8,9-hexahydro-4-hydroxy-2-methyl-1-oxo-6

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID87752	In vitro anticellular activity against HeLa S3 cells 72 hr after administration of the compound	1999	Bioorganic & medicinal chemistry letters, Oct-18, Volume: 9, Issue:20	Synthesis and antitumor activity of water-soluble duocarmycin B1 prodrugs.
AID201731	In vivo antitumor activity against Sarcoma 180 at dose 0.5 mg/kg	1999	Bioorganic & medicinal chemistry letters, Oct-18, Volume: 9, Issue:20	Synthesis and antitumor activity of water-soluble duocarmycin B1 prodrugs.
AID87751	In vitro anticellular activity against HeLa S3 cells 1 hr after administration of the compound	1999	Bioorganic & medicinal chemistry letters, Oct-18, Volume: 9, Issue:20	Synthesis and antitumor activity of water-soluble duocarmycin B1 prodrugs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (11.11)	18.7374
1990's	5 (55.56)	18.2507
2000's	3 (33.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (22.22%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (77.78%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	4.19	5	0	pyrrole; secondary amine
bromine Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.	1.97	1	0	diatomic bromine
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	1.97	1	0	diatomic chlorine; gas molecular entity	bleaching agent
duocarmycin sa duocarmycin SA: structure similar to CC-1065 and yatakemycin, composed of a pyrrolo-indole plus an indole; isolated from Streptomyces	4	4	0
pyrindamycin a pyrindamycin A: isolated from Streptomyces sp. SF2582	4.01	4	0
duocarmycin b2 duocarmycin B2: from Streptomyces sp. DO-89	4.47	7	0
cc 1065 CC 1065: from Streptomyces zelensis; structure in second sourc	4.02	2	0
dc 88-a duocarmycin A: from a Streptomycete	4.99	7	0

Condition	Indicated	Relationship Strength	Studies	Trials
Sarcoma 180 An experimental sarcoma of mice.	0	2	1	0
Experimental Neoplasms [description not available]	0	2	1	0
Leukemia L 1210 [description not available]	0	2.92	1	0