Compounds > duocarmycin b2
Page last updated: 2024-11-07

duocarmycin b2

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

duocarmycin B2: from Streptomyces sp. DO-89 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID147808
CHEMBL ID20070
SCHEMBL ID23567939
MeSH IDM0168423

Synonyms (13)

Synonym
CHEMBL20070
duocarmycin b2
methyl (2r,8s)-8-(bromomethyl)-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1h-indole-2-carbonyl)-7,8-dihydro-3h-pyrrolo[3,2-e]indole-2-carboxylate
benzo(1,2-b:4,3-b')dipyrrole-2-carboxylic acid, 8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-((5,6,7-trimethoxy-1h-indol-2-yl)carbonyl)-, methyl ester, (2r-trans)-
124325-94-6
benzo[1,2-b:4,3-b']dipyrrole-2-carboxylic acid, 8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-[(5,6,7-trimethoxy-1h-indol-2-yl)carbonyl]-, methyl ester, (2r,8s)-
DTXSID10924783
benzo1,2-b:4,3-bdipyrrole-2-carboxylic acid, 8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methy
SCHEMBL23567939
dc-89b2
methyl (2r,8s)-8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-[(5,6,7-trimethoxy-1h-indol-2-yl)carbonyl]benzo[1,2-b:4,3-b']dipyrrole-2-carboxylate
dc89b2
NJF66RR6DY
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (7.69)18.7374
1990's8 (61.54)18.2507
2000's2 (15.38)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyrroles
1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.		4.3460pyrrole;
secondary amine
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.		1.9710diatomic bromine
chlorine
Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.		1.9710diatomic chlorine;
gas molecular entity		bleaching agent
duocarmycin sa
duocarmycin SA: structure similar to CC-1065 and yatakemycin, composed of a pyrrolo-indole plus an indole; isolated from Streptomyces		440
kw 2189
KW 2189: structure given in first source		1.9810
pyrindamycin a
pyrindamycin A: isolated from Streptomyces sp. SF2582		4.0140
peplomycin
Peplomycin: An antineoplastic agent derived from BLEOMYCIN.		2.1710glycopeptide
cc 1065
CC 1065: from Streptomyces zelensis; structure in second sourc		3.1110
dc 88-a
duocarmycin A: from a Streptomycete		4.3460
duocarmycin b1
duocarmycin B1: from Streptomyces sp. DO-89		4.4770
ConditionIndicatedRelationship StrengthStudiesTrials
Sarcoma 180
An experimental sarcoma of mice.		02.940
Experimental Neoplasms
[description not available]		02.420
Cancer of the Uterus
[description not available]		01.9910
Uterine Neoplasms
Tumors or cancer of the UTERUS.		01.9910
Leukemia L 1210
[description not available]		02.9210