duocarmycin b2

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

duocarmycin B2: from Streptomyces sp. DO-89 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	147808
CHEMBL ID	20070
SCHEMBL ID	23567939
MeSH ID	M0168423

Synonyms (13)

Synonym
CHEMBL20070
duocarmycin b2
methyl (2r,8s)-8-(bromomethyl)-4-hydroxy-2-methyl-1-oxo-6-(5,6,7-trimethoxy-1h-indole-2-carbonyl)-7,8-dihydro-3h-pyrrolo[3,2-e]indole-2-carboxylate
benzo(1,2-b:4,3-b')dipyrrole-2-carboxylic acid, 8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-((5,6,7-trimethoxy-1h-indol-2-yl)carbonyl)-, methyl ester, (2r-trans)-
124325-94-6
benzo[1,2-b:4,3-b']dipyrrole-2-carboxylic acid, 8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-[(5,6,7-trimethoxy-1h-indol-2-yl)carbonyl]-, methyl ester, (2r,8s)-
DTXSID10924783
benzo1,2-b:4,3-bdipyrrole-2-carboxylic acid, 8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methy
SCHEMBL23567939
dc-89b2
methyl (2r,8s)-8-(bromomethyl)-1,2,3,6,7,8-hexahydro-4-hydroxy-2-methyl-1-oxo-6-[(5,6,7-trimethoxy-1h-indol-2-yl)carbonyl]benzo[1,2-b:4,3-b']dipyrrole-2-carboxylate
dc89b2
NJF66RR6DY

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (7.69)	18.7374
1990's	8 (61.54)	18.2507
2000's	2 (15.38)	29.6817
2010's	2 (15.38)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (7.69%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (92.31%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	4.34	6	pyrrole; secondary amine
bromine Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.	1.97	1	diatomic bromine
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	1.97	1	diatomic chlorine; gas molecular entity	bleaching agent
duocarmycin sa duocarmycin SA: structure similar to CC-1065 and yatakemycin, composed of a pyrrolo-indole plus an indole; isolated from Streptomyces	4	4
kw 2189 KW 2189: structure given in first source	1.98	1
pyrindamycin a pyrindamycin A: isolated from Streptomyces sp. SF2582	4.01	4
peplomycin Peplomycin: An antineoplastic agent derived from BLEOMYCIN.	2.17	1	glycopeptide
cc 1065 CC 1065: from Streptomyces zelensis; structure in second sourc	3.11	1
dc 88-a duocarmycin A: from a Streptomycete	4.34	6
duocarmycin b1 duocarmycin B1: from Streptomyces sp. DO-89	4.47	7

Condition	Relationship Strength	Studies
Sarcoma 180 An experimental sarcoma of mice.	2.9	4
Experimental Neoplasms [description not available]	2.4	2
Cancer of the Uterus [description not available]	1.99	1
Uterine Neoplasms Tumors or cancer of the UTERUS.	1.99	1
Leukemia L 1210 [description not available]	2.92	1

chemdatabank.com