duocarmycin sa has been researched along with dc 88-a in 13 studies
| Studies (duocarmycin sa) | Trials (duocarmycin sa) | Recent Studies (post-2010) (duocarmycin sa) | Studies (dc 88-a) | Trials (dc 88-a) | Recent Studies (post-2010) (dc 88-a) |
|---|---|---|---|---|---|
| 75 | 0 | 15 | 69 | 0 | 22 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ichimura, M; Katsumata, S; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K | 1 |
| Ichimura, M; Mihara, A; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K | 1 |
| Boger, DL; Nishi, T | 1 |
| Amishiro, N; Gomi, K; Kobayashi, E; Nagamura, S; Okamoto, A; Saito, H | 1 |
| Boger, DL; Hedrick, MP; Hughes, TV | 1 |
| Boger, DL; Hedrick, MP; Stauffer, F | 1 |
| Boger, DL; Brunette, SR; Garbaccio, RM | 1 |
| Boger, DL; Fink, BE; Hedrick, MP; Schmitt, HW | 1 |
| Searcey, M | 1 |
| Fukuyama, T; Kurokawa, T; Tokuyama, H; Yamada, K | 1 |
| Boger, DL; Hedrick, MP; Hwang, I; Kastrinsky, DB; Parrish, JP; Stauffer, F | 1 |
| Boger, DL; Ham, YW | 1 |
| Howard, T; Lee, M; Lingerfelt, B; McNulty, L; Pati, H; Townes, H | 1 |
1 review(s) available for duocarmycin sa and dc 88-a
| Article | Year |
|---|---|
Duocarmycins--natures prodrugs?
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Survival; DNA; Drug Stability; Duocarmycins; Indoles; Leucomycins; Leukemia L1210; Prodrugs; Pyrroles; Pyrrolidinones; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
12 other study(ies) available for duocarmycin sa and dc 88-a
| Article | Year |
|---|---|
Duocarmycins, new antitumor antibiotics produced by Streptomyces; producing organisms and improved production.
Topics: Antibiotics, Antineoplastic; Bromine; Carbon; Chlorine; Chromatography, High Pressure Liquid; Duocarmycins; Fermentation; Humans; Hydrogen-Ion Concentration; Indoles; Kinetics; Metals; Microscopy, Electron, Scanning; Nitrogen; Pyrroles; Pyrrolidinones; Streptomyces | 1991 |
Interconversion and stability of duocarmycins, a new family of antitumor antibiotics: correlation to their cytotoxic and antimicrobial activities in vitro.
Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line, Transformed; Drug Stability; Duocarmycins; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Pyrroles; Pyrrolidinones; Temperature | 1993 |
Diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center: development of a divergent strategy for the total synthesis of duocarmycins A and SA.
Topics: Antibiotics, Antineoplastic; Carbon; Duocarmycins; Indoles; Molecular Structure; Pyrroles; Pyrrolidinones | 1995 |
Synthesis and antitumor activity of duocarmycin derivatives: a-ring pyrrole compounds bearing 5-membered heteroarylacryloyl groups.
Topics: Acrylates; Animals; Antineoplastic Agents; Blood Cells; Combinatorial Chemistry Techniques; DNA; Duocarmycins; HeLa Cells; Humans; Indoles; Mice; Models, Chemical; Pyrroles; Pyrrolidinones; Sarcoma 180; Structure-Activity Relationship | 1999 |
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Crystallography, X-Ray; DNA; Duocarmycins; Indoles; Inhibitory Concentration 50; Kinetics; Leucomycins; Leukemia L1210; Mice; Pyrroles; Pyrrolidinones | 2001 |
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Topics: Adenine; Alkylation; Antibiotics, Antineoplastic; Binding Sites; DNA; DNA Adducts; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Leucomycins; Nucleic Acid Conformation; Pyrroles; Pyrrolidinones; Tumor Cells, Cultured | 2001 |
Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Duocarmycins; Humans; Indoles; Leucomycins; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyrroles; Pyrrolidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet | 2001 |
Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.
Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Binding Sites; Combinatorial Chemistry Techniques; Cyclopropanes; DNA; DNA, Viral; Duocarmycins; Indoles; Inhibitory Concentration 50; Leucomycins; Pyrroles; Pyrrolidinones; Simian virus 40; Structure-Activity Relationship | 2001 |
Total synthesis of the duocarmycins.
Topics: Antibiotics, Antineoplastic; Duocarmycins; Indoles; Pyrroles; Pyrrolidinones; Stereoisomerism; Streptomyces | 2003 |
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Topics: Alkylation; Amides; DNA; Duocarmycins; Indoles; Kinetics; Models, Molecular; Pyrroles; Pyrrolidinones; Sulfones | 2003 |
A powerful selection assay for mixture libraries of DNA alkylating agents.
Topics: Alkylating Agents; Alkylation; Binding, Competitive; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; DNA; Duocarmycins; Indoles; Pyrroles; Pyrrolidinones | 2004 |
Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
Topics: Antineoplastic Agents, Alkylating; Cyclization; Cyclopropanes; Duocarmycins; Humans; Indoles; Pyrroles; Pyrrolidinones | 2004 |