duocarmycin sa has been researched along with pyrroles in 72 studies
Studies (duocarmycin sa) | Trials (duocarmycin sa) | Recent Studies (post-2010) (duocarmycin sa) | Studies (pyrroles) | Trials (pyrroles) | Recent Studies (post-2010) (pyrroles) |
---|---|---|---|---|---|
75 | 0 | 15 | 26,129 | 2,815 | 12,100 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 11 (15.28) | 18.2507 |
2000's | 44 (61.11) | 29.6817 |
2010's | 17 (23.61) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Ichimura, M; Katsumata, S; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K | 1 |
Ichimura, M; Saitoh, Y; Sano, H; Takahashi, I; Yasuzawa, T | 1 |
Ichimura, M; Kawamoto, I; Kobayashi, E; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K; Yasuzawa, T | 1 |
Boger, DL; Johnson, DS | 1 |
Ichimura, M; Mihara, A; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K | 1 |
Boger, DL; Nishi, T | 1 |
Asai, A; Gomi, K; Kobayashi, E; Nagamura, S; Saito, H | 1 |
Boger, DL; Case, DA; Chazin, WJ; Eis, PS; Rydzewski, JM; Smith, JA | 1 |
Matsumura, N; Muratake, H; Natsume, M | 1 |
Amishiro, N; Gomi, K; Kobayashi, E; Nagamura, S; Okamoto, A; Saito, H | 1 |
Asai, A; Mizukami, T; Nakano, H; Yano, K | 1 |
Boger, DL; Jin, Q; Searcey, M; Tse, WC | 1 |
Boger, DL; Boyce, CW | 1 |
Boger, DL; Brunette, SR; Hedrick, MP; Jin, Q; Santillán, A; Searcey, M; Wolkenberg, SE | 1 |
Bifulco, G; Boger, DL; Case, DA; Chazin, WJ; Gomez-Paloma, L; Smith, JA | 1 |
Hayakawa, A; Muratake, H; Natsume, M | 1 |
Boger, DL; Hedrick, MP; Hughes, TV | 1 |
Denny, WA | 1 |
Haunert, F; Herzig, T; Lieb, M; Schuberth, I; Tietze, LF | 1 |
Boger, DL; Hedrick, MP; Stauffer, F | 1 |
Boger, DL; Brunette, SR; Garbaccio, RM | 1 |
Boger, DL; Ellis, DA; Wolkenberg, SE | 1 |
Boger, DL; Fink, BE; Hedrick, MP; Schmitt, HW | 1 |
Ambroise, Y; Boger, DL | 1 |
Searcey, M | 1 |
Ikariyama, Y; Kuwabara, T; Noda, T; Ohtake, H; Ohtake, T; Toyama, S | 1 |
Fukuyama, T; Kurokawa, T; Tokuyama, H; Yamada, K | 1 |
Boger, DL; Hedrick, MP; Hwang, I; Kastrinsky, DB; Parrish, JP; Stauffer, F | 1 |
Barone, V; Bifulco, G; Cimino, P; Gomez-Paloma, L; Improta, R; Riccio, R | 1 |
Boger, DL; Ham, YW | 1 |
Hiroya, K; Matsumoto, S; Sakamoto, T | 1 |
Barone, V; Cimino, P; Gomez-Paloma, L | 1 |
Brooks, N; Daniell, K; Handl, H; Hartley, JA; Kiakos, K; Le, M; Lee, M; Madsen, E; Stewart, M | 1 |
Boger, DL; Gottesfeld, JM; Trzupek, JD | 1 |
Gates, KS | 1 |
Carloni, P; Rothlisberger, U; Spiegel, K | 1 |
Flores, LV; Hartley, JA; Kiakos, K; Lee, M; Pennington, WT; Toth, JL; Trzupek, JD | 1 |
Frauendorf, H; Krewer, B; Major, F; Schuberth, I; Tietze, LF | 1 |
Major, F; Schuberth, I; Tietze, LF | 1 |
Boger, DL; Hwang, I; Kastrinsky, DB; Shiga, F; Tichenor, MS; Trzupek, JD | 1 |
Bringmann, G; Krewer, B; Magull, J; Major, F; Maksimenka, K; Schuberth, I; Spiegl, DA; Tietze, LF | 1 |
Asao, T; Hartley, JA; Kiakos, K; Lee, M; McHugh, PJ; Sato, A | 1 |
Baraldi, PG; Boger, DL; Hwang, I; MacMillan, KS; Pavani, MG; Rayl, TJ; Spalluto, G; Stover, JS; Tichenor, MS; Wolkenberg, SE; Zaid, AN; Zanella, L | 1 |
Howard, T; Lee, M; Lingerfelt, B; McNulty, L; Pati, H; Townes, H | 1 |
Abdullah, WN; Al-Said, NH; Shawakfeh, KQ | 1 |
Krewer, B; Major, F; Panknin, O; Tietze, LF | 1 |
Lee, M; Pradel, G; Purcell, LA; Rodriguez, A; Sato, A; Spithill, TW; Yanow, SK | 1 |
Alves, F; Schmuck, K; Schuberth, I; Schuster, HJ; Tietze, LF | 1 |
Alves, F; Krewer, B; Major, F; Müller, M; Schuberth, I; Schuster, HJ; Tietze, LF; von Hof, JM | 1 |
Krewer, B; Schuberth, I; Schuster, HJ; Tietze, LF | 1 |
Boger, DL; Hwang, I; MacMillan, KS; Nguyen, T | 1 |
Boger, DL; MacMillan, KS | 2 |
Krewer, B; Tietze, LF | 1 |
Baraldi, PG; Boger, DL; Cara, CL; Hwang, I; Lajiness, JP; MacMillan, KS; Robertson, WM; Romagnoli, R | 1 |
Boger, DL; Boyle, KE; Ellis, DA; Lajiness, JP; MacMillan, KS; Robertson, WM | 1 |
Boger, DL; Hwang, I; Kastrinsky, DB; Robertson, WM | 1 |
Alves, F; Krewer, B; Schmuck, K; Schuberth, I; Schuster, HJ; Tietze, LF; von Hof, JM | 1 |
Chen, N; Donat, U; Gentschev, I; Hess, M; Krewer, B; Seubert, CM; Stritzker, J; Sturm, JB; Szalay, AA; Tietze, LF; von Hof, JM | 1 |
Boger, DL; Lajiness, JP | 1 |
Boger, DL; Broward, MA; Dunwiddie, I; Lajiness, JP; Robertson, WM; Vielhauer, GA; Weir, SJ | 1 |
Müller, M; Schmuck, K; Schuberth, I; Schuster, HJ; Tietze, LF | 1 |
Schmuck, K; Sieber, SA; Tietze, LF; Wirth, T | 1 |
Chen, KC; Roffler, SR; Schmuck, K; Tietze, LF | 1 |
Boger, DL; Duerfeldt, AS; Duncan, KK; Lajiness, JP; Wolfe, AL; Zhu, K | 1 |
Liyanage, HD; McManaway, SP; Pruijn, FB; Tercel, M | 1 |
Alix, SM; Atwell, GJ; Liyanage, HD; O'Connor, PD; Pruijn, FB; Tercel, M | 1 |
Lee, M; Patil, PC; Satam, V | 1 |
Boger, DL; Boyle, KE; Brody, DM; Chanda, PB; Shukla, V | 1 |
Fontaine, SD; Hann, B; Mattis, AN; Renslo, AR; Sambucetti, L; Shi, Y; Spangler, B; Wells, JA | 1 |
Eastgate, MD; Park, H; Schmidt, MA; Simmons, EM; Wei, CS | 1 |
Boger, DL; Boyle, KE; Vazquez, M; Wroe, A | 1 |
5 review(s) available for duocarmycin sa and pyrroles
Article | Year |
---|---|
CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Consensus Sequence; DNA; Duocarmycins; Indoles; Leucomycins; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Pyrroles; Structure-Activity Relationship | 1995 |
DNA minor groove alkylating agents.
Topics: Alkylating Agents; Animals; Anthramycin; Antibiotics, Antineoplastic; Benzofurans; Bisbenzimidazole; Chlorambucil; Cyclohexanecarboxylic Acids; Cyclohexenes; Distamycins; DNA; Duocarmycins; Humans; Indoles; Netropsin; Nitrogen Mustard Compounds; Pyrroles; Structure-Activity Relationship | 2001 |
Duocarmycins--natures prodrugs?
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Survival; DNA; Drug Stability; Duocarmycins; Indoles; Leucomycins; Leukemia L1210; Prodrugs; Pyrroles; Pyrrolidinones; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Duocarmycins; Indoles; Molecular Structure; Pyrroles; Structure-Activity Relationship | 2009 |
A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Proliferation; DNA Methylation; DNA, Neoplasm; Duocarmycins; Humans; Indoles; Molecular Structure; Neoplasms; Pyrroles | 2015 |
67 other study(ies) available for duocarmycin sa and pyrroles
Article | Year |
---|---|
Duocarmycins, new antitumor antibiotics produced by Streptomyces; producing organisms and improved production.
Topics: Antibiotics, Antineoplastic; Bromine; Carbon; Chlorine; Chromatography, High Pressure Liquid; Duocarmycins; Fermentation; Humans; Hydrogen-Ion Concentration; Indoles; Kinetics; Metals; Microscopy, Electron, Scanning; Nitrogen; Pyrroles; Pyrrolidinones; Streptomyces | 1991 |
Structure of duocarmycin SA, a potent antitumor antibiotic.
Topics: Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Duocarmycins; Indoles; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Pyrroles | 1991 |
Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp.
Topics: Animals; Antibiotics, Antineoplastic; Duocarmycins; Indoles; Leukemia P388; Mice; Molecular Structure; Pyrroles; Sarcoma 180; Soil Microbiology; Streptomyces | 1990 |
Interconversion and stability of duocarmycins, a new family of antitumor antibiotics: correlation to their cytotoxic and antimicrobial activities in vitro.
Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line, Transformed; Drug Stability; Duocarmycins; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Pyrroles; Pyrrolidinones; Temperature | 1993 |
Diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center: development of a divergent strategy for the total synthesis of duocarmycins A and SA.
Topics: Antibiotics, Antineoplastic; Carbon; Duocarmycins; Indoles; Molecular Structure; Pyrroles; Pyrrolidinones | 1995 |
Studies on duocarmycin SA and its derivatives.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Drug Stability; Duocarmycins; HeLa Cells; Humans; Indoles; Mice; Models, Chemical; Pyrroles; Tumor Cells, Cultured | 1997 |
High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA.
Topics: Antineoplastic Agents, Alkylating; Binding Sites; DNA; Duocarmycins; Indoles; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Pyrroles | 1997 |
Preparation of alkyl-substituted indoles in the benzene portion. Part 15. Asymmetric synthesis of (+)-duocarmycin SA using novel procedure for preparation of hydroxyindoles.
Topics: Alkylation; Antibiotics, Antineoplastic; Carboxylic Acids; Duocarmycins; Indoles; Malates; Models, Chemical; Nitro Compounds; Pyrroles; Stereoisomerism | 1998 |
Synthesis and antitumor activity of duocarmycin derivatives: a-ring pyrrole compounds bearing 5-membered heteroarylacryloyl groups.
Topics: Acrylates; Animals; Antineoplastic Agents; Blood Cells; Combinatorial Chemistry Techniques; DNA; Duocarmycins; HeLa Cells; Humans; Indoles; Mice; Models, Chemical; Pyrroles; Pyrrolidinones; Sarcoma 180; Structure-Activity Relationship | 1999 |
Characterization of a duocarmycin-DNA adduct-recognizing protein in cancer cells.
Topics: Animals; Anthramycin; Antibiotics, Antineoplastic; Apoptosis; Binding, Competitive; Cattle; Cell Nucleus; DNA; DNA Adducts; DNA-Binding Proteins; Duocarmycins; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Indoles; Leucomycins; Nuclear Proteins; Oligonucleotides; Pyrroles; Ribonucleoproteins; Thymus Gland; Tumor Cells, Cultured | 1999 |
Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.
Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Catalysis; DNA; Duocarmycins; Indoles; Leukemia L1210; Pyrroles; Stereoisomerism | 2000 |
Selective metal cation activation of a DNA alkylating agent: synthesis and evaluation of methyl 1,2,9, 9a-Tetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate (CPyI).
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Base Sequence; Catalysis; Cations, Divalent; DNA; DNA, Viral; Duocarmycins; Indicators and Reagents; Indoles; Metals; Molecular Conformation; Molecular Structure; Pyrroles; Quinolones; Spectrophotometry, Ultraviolet; Stereoisomerism | 2000 |
Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis.
Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Sequence; Crystallography, X-Ray; DNA; DNA, Viral; Duocarmycins; Indicators and Reagents; Indolequinones; Indoles; Leucomycins; Models, Molecular; Molecular Conformation; Molecular Structure; Oligodeoxyribonucleotides; Pyrroles; Quinolones | 2000 |
The structural basis for in situ activation of DNA alkylation by duocarmycin SA.
Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; DNA Adducts; Duocarmycins; Indoles; Kinetics; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Oligodeoxyribonucleotides; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Thermodynamics | 2000 |
Preparation of benzene, furan, and thiophene analogs of duocarmycin SA employing a newly-devised phenol-forming reaction.
Topics: Benzene; Duocarmycins; Furans; Indoles; Molecular Structure; Pyrroles; Spectrum Analysis; Thiophenes | 2000 |
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Crystallography, X-Ray; DNA; Duocarmycins; Indoles; Inhibitory Concentration 50; Kinetics; Leucomycins; Leukemia L1210; Mice; Pyrroles; Pyrrolidinones | 2001 |
A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs.
Topics: Antibiotics, Antineoplastic; Antibodies; Bronchial Neoplasms; Duocarmycins; Humans; Indoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Prodrugs; Pyrroles; Tumor Cells, Cultured | 2001 |
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Topics: Adenine; Alkylation; Antibiotics, Antineoplastic; Binding Sites; DNA; DNA Adducts; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Leucomycins; Nucleic Acid Conformation; Pyrroles; Pyrrolidinones; Tumor Cells, Cultured | 2001 |
Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins.
Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Duocarmycins; Humans; Indoles; Leucomycins; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyrroles; Pyrrolidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet | 2001 |
Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis.
Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Leukemia L1210; Pyrroles; Quinolones; Stereoisomerism | 2001 |
Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.
Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Binding Sites; Combinatorial Chemistry Techniques; Cyclopropanes; DNA; DNA, Viral; Duocarmycins; Indoles; Inhibitory Concentration 50; Leucomycins; Pyrroles; Pyrrolidinones; Simian virus 40; Structure-Activity Relationship | 2001 |
The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction.
Topics: Algorithms; Alkylation; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Magnetic Resonance Spectroscopy; Phosphates; Pyrroles | 2002 |
Classification of DNA-binding mode of antitumor and antiviral agents by the electrochemiluminescence of ruthenium complex.
Topics: Antineoplastic Agents; Antiviral Agents; Cisplatin; Dactinomycin; Distamycins; DNA; Dose-Response Relationship, Drug; Duocarmycins; Electrochemistry; Indoles; Luminescent Measurements; Macromolecular Substances; Mitomycin; Molecular Structure; Pyrroles; Ruthenium | 2003 |
Total synthesis of the duocarmycins.
Topics: Antibiotics, Antineoplastic; Duocarmycins; Indoles; Pyrroles; Pyrrolidinones; Stereoisomerism; Streptomyces | 2003 |
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Topics: Alkylation; Amides; DNA; Duocarmycins; Indoles; Kinetics; Models, Molecular; Pyrroles; Pyrrolidinones; Sulfones | 2003 |
Nucleophilic cyclopropane ring opening in duocarmycin SA derivatives by methanol under acid conditions: a quantum mechanical study in the gas-phase and in solution.
Topics: Antibiotics, Antineoplastic; Catalysis; Cyclopropanes; Duocarmycins; Gases; Hydrogen-Ion Concentration; Indoles; Methanol; Molecular Structure; Pyrroles; Solutions | 2004 |
A powerful selection assay for mixture libraries of DNA alkylating agents.
Topics: Alkylating Agents; Alkylation; Binding, Competitive; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; DNA; Duocarmycins; Indoles; Pyrroles; Pyrrolidinones | 2004 |
New synthetic method for indole-2-carboxylate and its application to the total synthesis of duocarmycin SA.
Topics: Cyclization; Duocarmycins; Indoles; Molecular Structure; Pyrroles | 2004 |
Regioselectivity and nucleophilic control in the cyclopropane ring opening of duocarmycin SA derivatives under neutral and acid conditions: a quantum mechanical study in the gas phase and in solution.
Topics: Cyclopropanes; Duocarmycins; Indoles; Models, Molecular; Molecular Conformation; Molecular Structure; Pyridines; Pyrroles; Stereoisomerism; Thermodynamics | 2004 |
Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.
Topics: Base Sequence; Cell Line, Tumor; DNA Damage; DNA Primers; Drug Evaluation, Preclinical; Duocarmycins; Humans; Indoles; Pyrroles | 2005 |
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
Topics: Antineoplastic Agents, Alkylating; DNA; Duocarmycins; Indoles; Nucleosomes; Pyrroles | 2006 |
Getting under wraps: alkylating DNA in the nucleosome.
Topics: Antineoplastic Agents, Alkylating; DNA; Duocarmycins; Indoles; Nucleosomes; Pyrroles | 2006 |
Duocarmycins binding to DNA investigated by molecular simulation.
Topics: Adenine; Algorithms; Alkylation; Antineoplastic Agents, Alkylating; Base Sequence; Binding Sites; Catalysis; Computer Simulation; DNA; Duocarmycins; Hydrogen Bonding; Indoles; Molecular Conformation; Oligonucleotides; Pyrroles | 2006 |
A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; K562 Cells; Molecular Structure; Pyrroles; Stereoisomerism | 2005 |
Investigation of reactivity and selectivity of DNA-alkylating duocarmycin analogues by high-resolution mass spectrometry.
Topics: Alkylating Agents; Cell Survival; Crystallography, X-Ray; DNA; DNA Fragmentation; Duocarmycins; Electrophoresis, Polyacrylamide Gel; Indicators and Reagents; Indoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Prodrugs; Pyrroles; Spectrometry, Mass, Electrospray Ionization | 2006 |
Antitumor agents: development of highly potent glycosidic duocarmycin analogues for selective cancer therapy.
Topics: Alkylating Agents; Antibodies; Cell Line, Tumor; Drug Delivery Systems; Duocarmycins; Humans; Indoles; Neoplasms; Prodrugs; Pyrroles; Streptomyces; Tumor Stem Cell Assay | 2006 |
Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.
Topics: Adenine; Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Pairing; Base Sequence; DNA; Duocarmycins; Hydrogen-Ion Concentration; Indoles; Kinetics; Models, Chemical; Pyrroles; Stereoisomerism; Streptomyces; Temperature | 2006 |
Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Lung Neoplasms; Molecular Structure; Prodrugs; Pyrroles; Stereoisomerism | 2007 |
DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
Topics: Adenine; Alkylating Agents; Alkylation; Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Cricetulus; DNA Adducts; DNA Damage; DNA Repair; Drug Evaluation, Preclinical; Duocarmycins; Humans; Indoles; Mice; Molecular Structure; Pyrroles; Saccharomyces cerevisiae; Structure-Activity Relationship; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2007 |
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
Topics: Alkylation; Animals; Antiparasitic Agents; Cell Line, Tumor; Combinatorial Chemistry Techniques; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Design; Duocarmycins; Indoles; Injections, Intraperitoneal; Mice; Mice, Inbred DBA; Molecular Structure; Pyrroles; Stereoisomerism; Survival Rate; Xenograft Model Antitumor Assays | 2007 |
Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
Topics: Antineoplastic Agents, Alkylating; Cyclization; Cyclopropanes; Duocarmycins; Humans; Indoles; Pyrroles; Pyrrolidinones | 2004 |
Cyclization of free radicals at the C-7 position of ethyl indole-2-carboxylate derivatives: an entry to a new class of Duocarmycin Analogues.
Topics: Alkylating Agents; Cyclization; Duocarmycins; Free Radicals; Indoles; Molecular Structure; Pyrroles; Quinolines | 2005 |
Synthesis of a novel pentagastrin-drug conjugate for a targeted tumor therapy.
Topics: Antineoplastic Agents; Catalysis; Cell Proliferation; Drug Delivery Systems; Duocarmycins; Esters; Indoles; Molecular Structure; Palladium; Pentagastrin; Pyrroles; Receptor, Cholecystokinin B | 2008 |
Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agent.
Topics: Alkylating Agents; Animals; Anopheles; Antimalarials; Disease Models, Animal; Duocarmycins; Female; Indoles; Mice; Oocysts; Plasmodium; Pyrroles; Sporozoites | 2008 |
Duocarmycin-based prodrugs for cancer prodrug monotherapy.
Topics: Antineoplastic Agents; Cell Line, Tumor; Duocarmycins; Glucuronates; Glucuronic Acid; Humans; Indoles; Inhibitory Concentration 50; Neoplasms; Prodrugs; Pyrroles | 2008 |
Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy.
Topics: Antineoplastic Agents; beta-Galactosidase; Cell Line, Tumor; Duocarmycins; Glycosides; Humans; Indoles; Inhibitory Concentration 50; Neoplasms; Prodrugs; Pyrroles; Stereoisomerism | 2008 |
Synthesis and biological studies of different duocarmycin based glycosidic prodrugs for their use in the antibody-directed enzyme prodrug therapy.
Topics: Antibodies; beta-Galactosidase; Chromatography, High Pressure Liquid; Duocarmycins; Glycosides; Indoles; Magnetic Resonance Spectroscopy; Neoplasms; Prodrugs; Pyrroles; Spectrometry, Mass, Electrospray Ionization | 2009 |
Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.
Topics: Alkylation; Animals; Biological Products; Cell Line, Tumor; Cell Survival; DNA; Duocarmycins; Indoles; Isomerism; Mice; Molecular Structure; Pyrroles; Solubility; Structure-Activity Relationship | 2009 |
An additional spirocyclization for duocarmycin SA.
Topics: Alkylation; Antineoplastic Agents; Cyclization; Duocarmycins; Hydrogen-Ion Concentration; Indoles; Kinetics; Pyrroles | 2008 |
Antibody-directed enzyme prodrug therapy: a promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; beta-Galactosidase; Cell Line, Tumor; Drug Design; Duocarmycins; Glycosides; Humans; Indoles; Neoplasms; Prodrugs; Pyrroles; Stereoisomerism | 2009 |
Synthesis and evaluation of a thio analogue of duocarmycin SA.
Topics: Antineoplastic Agents, Alkylating; Duocarmycins; Indoles; Pyrroles; Sulfhydryl Compounds; Thiophenes | 2009 |
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
Topics: Alkylating Agents; Alkylation; Duocarmycins; Indoles; Oxazoles; Pyrroles | 2010 |
Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.
Topics: Alkylating Agents; Animals; Cell Line, Tumor; DNA; Duocarmycins; Indoles; Mice; Pyrroles; Structure-Activity Relationship | 2010 |
Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity.
Topics: Alkylating Agents; Anti-Bacterial Agents; Cell Line, Tumor; Cytostatic Agents; DNA; Duocarmycins; Humans; Indoles; Prodrugs; Pyrroles | 2010 |
Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a β-galactosidase-activatable prodrug seco-analog of duocarmycin SA.
Topics: Animals; beta-Galactosidase; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Duocarmycins; Female; Humans; Indoles; Mice; Mice, Nude; Microscopy, Fluorescence; Oncolytic Virotherapy; Prodrugs; Pyrroles; Vaccinia virus; Xenograft Model Antitumor Assays | 2011 |
Synthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one (CbBI) alkylation subunit.
Topics: Alkylation; Crystallography, X-Ray; Cyclization; Cyclobutanes; Duocarmycins; Entropy; Heterocyclic Compounds, 4 or More Rings; Indoles; Models, Molecular; Molecular Structure; Pyrroles; Stereoisomerism | 2010 |
Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.
Topics: Animals; Antineoplastic Agents, Alkylating; Drug Screening Assays, Antitumor; Duocarmycins; Indoles; Leukemia L1210; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Phenols; Prodrugs; Pyrroles; Stereoisomerism; Structure-Activity Relationship | 2010 |
Synthesis and biological evaluation of prodrugs based on the natural antibiotic duocarmycin for use in ADEPT and PMT.
Topics: Antibodies; DNA; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Glucuronidase; Humans; Indoles; Inhibitory Concentration 50; Molecular Structure; Prodrugs; Pyrroles | 2011 |
Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells.
Topics: Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents, Alkylating; Binding Sites; Cell Line, Tumor; Cell Proliferation; Duocarmycins; Humans; Indoles; Isoenzymes; Lung Neoplasms; Pyrroles; Recombinant Proteins; Retinal Dehydrogenase; Tandem Mass Spectrometry | 2012 |
Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue.
Topics: Adenoviridae; Animals; Antineoplastic Agents; Cell Line, Tumor; Duocarmycins; Extracellular Fluid; Female; Genetic Vectors; Glucuronidase; Glucuronides; Humans; Indoles; Mice; Mice, Nude; Molecular Structure; Prodrugs; Pyrroles; RNA, Small Interfering; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2013 |
A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding.
Topics: Animals; Antineoplastic Agents, Alkylating; Binding Sites; Cell Line, Tumor; DNA; Duocarmycins; Hydrophobic and Hydrophilic Interactions; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mice; Pyrroles; Solubility; Spectrometry, Mass, Electrospray Ionization | 2013 |
Preparation and properties of clickable amino analogues of the duocarmycins: factors that affect the efficiency of their fluorescent labelling of DNA.
Topics: Alkylation; Alkynes; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Click Chemistry; DNA; Dogs; Drug Screening Assays, Antitumor; Duocarmycins; Fluorescent Dyes; Humans; Indoles; Pyrroles | 2014 |
Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.
Topics: Animals; Antibiotics, Antineoplastic; Cricetinae; Cricetulus; Cyclopropanes; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Hydrogen-Ion Concentration; Indoles; Kinetics; Mice; Protons; Pyrroles | 2014 |
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Duocarmycins; Imidazoles; Indoles; Mice; Molecular Structure; Pyrroles; Stereoisomerism | 2016 |
A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; Duocarmycins; Female; Ferrous Compounds; Humans; Indoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Molecular Structure; Prodrugs; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
An Enantioselective Total Synthesis of (+)-Duocarmycin SA.
Topics: Cyclization; Duocarmycins; Hydrogenation; Indoles; Molecular Structure; Pyrroles; Stereoisomerism | 2018 |
Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
Topics: Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Duocarmycins; Glioblastoma; Humans; Indoles; Necrosis; Protons; Pyrroles; Radiation-Sensitizing Agents | 2018 |