Page last updated: 2024-09-03

duocarmycin sa and pyrroles

duocarmycin sa has been researched along with pyrroles in 72 studies

Compound Research Comparison

Studies
(duocarmycin sa)
Trials
(duocarmycin sa)
Recent Studies (post-2010)
(duocarmycin sa)
Studies
(pyrroles)
Trials
(pyrroles)
Recent Studies (post-2010) (pyrroles)
7501526,1292,81512,100

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (15.28)18.2507
2000's44 (61.11)29.6817
2010's17 (23.61)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ichimura, M; Katsumata, S; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K1
Ichimura, M; Saitoh, Y; Sano, H; Takahashi, I; Yasuzawa, T1
Ichimura, M; Kawamoto, I; Kobayashi, E; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K; Yasuzawa, T1
Boger, DL; Johnson, DS1
Ichimura, M; Mihara, A; Nakano, H; Ogawa, T; Takahashi, I; Takahashi, K1
Boger, DL; Nishi, T1
Asai, A; Gomi, K; Kobayashi, E; Nagamura, S; Saito, H1
Boger, DL; Case, DA; Chazin, WJ; Eis, PS; Rydzewski, JM; Smith, JA1
Matsumura, N; Muratake, H; Natsume, M1
Amishiro, N; Gomi, K; Kobayashi, E; Nagamura, S; Okamoto, A; Saito, H1
Asai, A; Mizukami, T; Nakano, H; Yano, K1
Boger, DL; Jin, Q; Searcey, M; Tse, WC1
Boger, DL; Boyce, CW1
Boger, DL; Brunette, SR; Hedrick, MP; Jin, Q; Santillán, A; Searcey, M; Wolkenberg, SE1
Bifulco, G; Boger, DL; Case, DA; Chazin, WJ; Gomez-Paloma, L; Smith, JA1
Hayakawa, A; Muratake, H; Natsume, M1
Boger, DL; Hedrick, MP; Hughes, TV1
Denny, WA1
Haunert, F; Herzig, T; Lieb, M; Schuberth, I; Tietze, LF1
Boger, DL; Hedrick, MP; Stauffer, F1
Boger, DL; Brunette, SR; Garbaccio, RM1
Boger, DL; Ellis, DA; Wolkenberg, SE1
Boger, DL; Fink, BE; Hedrick, MP; Schmitt, HW1
Ambroise, Y; Boger, DL1
Searcey, M1
Ikariyama, Y; Kuwabara, T; Noda, T; Ohtake, H; Ohtake, T; Toyama, S1
Fukuyama, T; Kurokawa, T; Tokuyama, H; Yamada, K1
Boger, DL; Hedrick, MP; Hwang, I; Kastrinsky, DB; Parrish, JP; Stauffer, F1
Barone, V; Bifulco, G; Cimino, P; Gomez-Paloma, L; Improta, R; Riccio, R1
Boger, DL; Ham, YW1
Hiroya, K; Matsumoto, S; Sakamoto, T1
Barone, V; Cimino, P; Gomez-Paloma, L1
Brooks, N; Daniell, K; Handl, H; Hartley, JA; Kiakos, K; Le, M; Lee, M; Madsen, E; Stewart, M1
Boger, DL; Gottesfeld, JM; Trzupek, JD1
Gates, KS1
Carloni, P; Rothlisberger, U; Spiegel, K1
Flores, LV; Hartley, JA; Kiakos, K; Lee, M; Pennington, WT; Toth, JL; Trzupek, JD1
Frauendorf, H; Krewer, B; Major, F; Schuberth, I; Tietze, LF1
Major, F; Schuberth, I; Tietze, LF1
Boger, DL; Hwang, I; Kastrinsky, DB; Shiga, F; Tichenor, MS; Trzupek, JD1
Bringmann, G; Krewer, B; Magull, J; Major, F; Maksimenka, K; Schuberth, I; Spiegl, DA; Tietze, LF1
Asao, T; Hartley, JA; Kiakos, K; Lee, M; McHugh, PJ; Sato, A1
Baraldi, PG; Boger, DL; Hwang, I; MacMillan, KS; Pavani, MG; Rayl, TJ; Spalluto, G; Stover, JS; Tichenor, MS; Wolkenberg, SE; Zaid, AN; Zanella, L1
Howard, T; Lee, M; Lingerfelt, B; McNulty, L; Pati, H; Townes, H1
Abdullah, WN; Al-Said, NH; Shawakfeh, KQ1
Krewer, B; Major, F; Panknin, O; Tietze, LF1
Lee, M; Pradel, G; Purcell, LA; Rodriguez, A; Sato, A; Spithill, TW; Yanow, SK1
Alves, F; Schmuck, K; Schuberth, I; Schuster, HJ; Tietze, LF1
Alves, F; Krewer, B; Major, F; Müller, M; Schuberth, I; Schuster, HJ; Tietze, LF; von Hof, JM1
Krewer, B; Schuberth, I; Schuster, HJ; Tietze, LF1
Boger, DL; Hwang, I; MacMillan, KS; Nguyen, T1
Boger, DL; MacMillan, KS2
Krewer, B; Tietze, LF1
Baraldi, PG; Boger, DL; Cara, CL; Hwang, I; Lajiness, JP; MacMillan, KS; Robertson, WM; Romagnoli, R1
Boger, DL; Boyle, KE; Ellis, DA; Lajiness, JP; MacMillan, KS; Robertson, WM1
Boger, DL; Hwang, I; Kastrinsky, DB; Robertson, WM1
Alves, F; Krewer, B; Schmuck, K; Schuberth, I; Schuster, HJ; Tietze, LF; von Hof, JM1
Chen, N; Donat, U; Gentschev, I; Hess, M; Krewer, B; Seubert, CM; Stritzker, J; Sturm, JB; Szalay, AA; Tietze, LF; von Hof, JM1
Boger, DL; Lajiness, JP1
Boger, DL; Broward, MA; Dunwiddie, I; Lajiness, JP; Robertson, WM; Vielhauer, GA; Weir, SJ1
Müller, M; Schmuck, K; Schuberth, I; Schuster, HJ; Tietze, LF1
Schmuck, K; Sieber, SA; Tietze, LF; Wirth, T1
Chen, KC; Roffler, SR; Schmuck, K; Tietze, LF1
Boger, DL; Duerfeldt, AS; Duncan, KK; Lajiness, JP; Wolfe, AL; Zhu, K1
Liyanage, HD; McManaway, SP; Pruijn, FB; Tercel, M1
Alix, SM; Atwell, GJ; Liyanage, HD; O'Connor, PD; Pruijn, FB; Tercel, M1
Lee, M; Patil, PC; Satam, V1
Boger, DL; Boyle, KE; Brody, DM; Chanda, PB; Shukla, V1
Fontaine, SD; Hann, B; Mattis, AN; Renslo, AR; Sambucetti, L; Shi, Y; Spangler, B; Wells, JA1
Eastgate, MD; Park, H; Schmidt, MA; Simmons, EM; Wei, CS1
Boger, DL; Boyle, KE; Vazquez, M; Wroe, A1

Reviews

5 review(s) available for duocarmycin sa and pyrroles

ArticleYear
CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Apr-25, Volume: 92, Issue:9

    Topics: Alkylating Agents; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Consensus Sequence; DNA; Duocarmycins; Indoles; Leucomycins; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Pyrroles; Structure-Activity Relationship

1995
DNA minor groove alkylating agents.
    Current medicinal chemistry, 2001, Volume: 8, Issue:5

    Topics: Alkylating Agents; Animals; Anthramycin; Antibiotics, Antineoplastic; Benzofurans; Bisbenzimidazole; Chlorambucil; Cyclohexanecarboxylic Acids; Cyclohexenes; Distamycins; DNA; Duocarmycins; Humans; Indoles; Netropsin; Nitrogen Mustard Compounds; Pyrroles; Structure-Activity Relationship

2001
Duocarmycins--natures prodrugs?
    Current pharmaceutical design, 2002, Volume: 8, Issue:15

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Cell Survival; DNA; Drug Stability; Duocarmycins; Indoles; Leucomycins; Leukemia L1210; Prodrugs; Pyrroles; Pyrrolidinones; Structure-Activity Relationship; Tumor Cells, Cultured

2002
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
    Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19

    Topics: Alkylating Agents; Antibiotics, Antineoplastic; Duocarmycins; Indoles; Molecular Structure; Pyrroles; Structure-Activity Relationship

2009
A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents.
    Anti-cancer agents in medicinal chemistry, 2015, Volume: 15, Issue:5

    Topics: Animals; Antineoplastic Agents, Alkylating; Cell Proliferation; DNA Methylation; DNA, Neoplasm; Duocarmycins; Humans; Indoles; Molecular Structure; Neoplasms; Pyrroles

2015

Other Studies

67 other study(ies) available for duocarmycin sa and pyrroles

ArticleYear
Duocarmycins, new antitumor antibiotics produced by Streptomyces; producing organisms and improved production.
    The Journal of antibiotics, 1991, Volume: 44, Issue:10

    Topics: Antibiotics, Antineoplastic; Bromine; Carbon; Chlorine; Chromatography, High Pressure Liquid; Duocarmycins; Fermentation; Humans; Hydrogen-Ion Concentration; Indoles; Kinetics; Metals; Microscopy, Electron, Scanning; Nitrogen; Pyrroles; Pyrrolidinones; Streptomyces

1991
Structure of duocarmycin SA, a potent antitumor antibiotic.
    The Journal of antibiotics, 1991, Volume: 44, Issue:4

    Topics: Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry, Physical; Duocarmycins; Indoles; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Pyrroles

1991
Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp.
    The Journal of antibiotics, 1990, Volume: 43, Issue:8

    Topics: Animals; Antibiotics, Antineoplastic; Duocarmycins; Indoles; Leukemia P388; Mice; Molecular Structure; Pyrroles; Sarcoma 180; Soil Microbiology; Streptomyces

1990
Interconversion and stability of duocarmycins, a new family of antitumor antibiotics: correlation to their cytotoxic and antimicrobial activities in vitro.
    Oncology research, 1993, Volume: 5, Issue:4-5

    Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line, Transformed; Drug Stability; Duocarmycins; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Pyrroles; Pyrrolidinones; Temperature

1993
Diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center: development of a divergent strategy for the total synthesis of duocarmycins A and SA.
    Bioorganic & medicinal chemistry, 1995, Volume: 3, Issue:1

    Topics: Antibiotics, Antineoplastic; Carbon; Duocarmycins; Indoles; Molecular Structure; Pyrroles; Pyrrolidinones

1995
Studies on duocarmycin SA and its derivatives.
    Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Drug Stability; Duocarmycins; HeLa Cells; Humans; Indoles; Mice; Models, Chemical; Pyrroles; Tumor Cells, Cultured

1997
High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA.
    Journal of molecular biology, 1997, Sep-19, Volume: 272, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Binding Sites; DNA; Duocarmycins; Indoles; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Pyrroles

1997
Preparation of alkyl-substituted indoles in the benzene portion. Part 15. Asymmetric synthesis of (+)-duocarmycin SA using novel procedure for preparation of hydroxyindoles.
    Chemical & pharmaceutical bulletin, 1998, Volume: 46, Issue:4

    Topics: Alkylation; Antibiotics, Antineoplastic; Carboxylic Acids; Duocarmycins; Indoles; Malates; Models, Chemical; Nitro Compounds; Pyrroles; Stereoisomerism

1998
Synthesis and antitumor activity of duocarmycin derivatives: a-ring pyrrole compounds bearing 5-membered heteroarylacryloyl groups.
    Chemical & pharmaceutical bulletin, 1999, Volume: 47, Issue:10

    Topics: Acrylates; Animals; Antineoplastic Agents; Blood Cells; Combinatorial Chemistry Techniques; DNA; Duocarmycins; HeLa Cells; Humans; Indoles; Mice; Models, Chemical; Pyrroles; Pyrrolidinones; Sarcoma 180; Structure-Activity Relationship

1999
Characterization of a duocarmycin-DNA adduct-recognizing protein in cancer cells.
    Cancer research, 1999, Nov-01, Volume: 59, Issue:21

    Topics: Animals; Anthramycin; Antibiotics, Antineoplastic; Apoptosis; Binding, Competitive; Cattle; Cell Nucleus; DNA; DNA Adducts; DNA-Binding Proteins; Duocarmycins; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Humans; Indoles; Leucomycins; Nuclear Proteins; Oligonucleotides; Pyrroles; Ribonucleoproteins; Thymus Gland; Tumor Cells, Cultured

1999
Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.
    Bioorganic & medicinal chemistry letters, 2000, Mar-06, Volume: 10, Issue:5

    Topics: Alkylation; Animals; Antineoplastic Agents, Alkylating; Catalysis; DNA; Duocarmycins; Indoles; Leukemia L1210; Pyrroles; Stereoisomerism

2000
Selective metal cation activation of a DNA alkylating agent: synthesis and evaluation of methyl 1,2,9, 9a-Tetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate (CPyI).
    The Journal of organic chemistry, 2000, Jun-30, Volume: 65, Issue:13

    Topics: Alkylating Agents; Antibiotics, Antineoplastic; Base Sequence; Catalysis; Cations, Divalent; DNA; DNA, Viral; Duocarmycins; Indicators and Reagents; Indoles; Metals; Molecular Conformation; Molecular Structure; Pyrroles; Quinolones; Spectrophotometry, Ultraviolet; Stereoisomerism

2000
Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis.
    The Journal of organic chemistry, 2000, Jun-30, Volume: 65, Issue:13

    Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Sequence; Crystallography, X-Ray; DNA; DNA, Viral; Duocarmycins; Indicators and Reagents; Indolequinones; Indoles; Leucomycins; Models, Molecular; Molecular Conformation; Molecular Structure; Oligodeoxyribonucleotides; Pyrroles; Quinolones

2000
The structural basis for in situ activation of DNA alkylation by duocarmycin SA.
    Journal of molecular biology, 2000, Jul-28, Volume: 300, Issue:5

    Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; DNA Adducts; Duocarmycins; Indoles; Kinetics; Models, Molecular; Molecular Conformation; Nuclear Magnetic Resonance, Biomolecular; Oligodeoxyribonucleotides; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Thermodynamics

2000
Preparation of benzene, furan, and thiophene analogs of duocarmycin SA employing a newly-devised phenol-forming reaction.
    Chemical & pharmaceutical bulletin, 2000, Volume: 48, Issue:10

    Topics: Benzene; Duocarmycins; Furans; Indoles; Molecular Structure; Pyrroles; Spectrum Analysis; Thiophenes

2000
Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.
    The Journal of organic chemistry, 2001, Apr-06, Volume: 66, Issue:7

    Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Crystallography, X-Ray; DNA; Duocarmycins; Indoles; Inhibitory Concentration 50; Kinetics; Leucomycins; Leukemia L1210; Mice; Pyrroles; Pyrrolidinones

2001
A strategy for tumor-selective chemotherapy by enzymatic liberation of seco-duocarmycin SA-derivatives from nontoxic prodrugs.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:7

    Topics: Antibiotics, Antineoplastic; Antibodies; Bronchial Neoplasms; Duocarmycins; Humans; Indoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Prodrugs; Pyrroles; Tumor Cells, Cultured

2001
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
    Bioorganic & medicinal chemistry letters, 2001, Aug-06, Volume: 11, Issue:15

    Topics: Adenine; Alkylation; Antibiotics, Antineoplastic; Binding Sites; DNA; DNA Adducts; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Leucomycins; Nucleic Acid Conformation; Pyrroles; Pyrrolidinones; Tumor Cells, Cultured

2001
Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins.
    The Journal of organic chemistry, 2001, Jul-27, Volume: 66, Issue:15

    Topics: Alkylation; Animals; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Duocarmycins; Humans; Indoles; Leucomycins; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Conformation; Pyrroles; Pyrrolidinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet

2001
Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis.
    Journal of the American Chemical Society, 2001, Sep-26, Volume: 123, Issue:38

    Topics: Alkylating Agents; Animals; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Leukemia L1210; Pyrroles; Quinolones; Stereoisomerism

2001
Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.
    The Journal of organic chemistry, 2001, Oct-05, Volume: 66, Issue:20

    Topics: Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Binding Sites; Combinatorial Chemistry Techniques; Cyclopropanes; DNA; DNA, Viral; Duocarmycins; Indoles; Inhibitory Concentration 50; Leucomycins; Pyrroles; Pyrrolidinones; Simian virus 40; Structure-Activity Relationship

2001
The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction.
    Bioorganic & medicinal chemistry letters, 2002, Feb-11, Volume: 12, Issue:3

    Topics: Algorithms; Alkylation; Antibiotics, Antineoplastic; Catalysis; DNA; Duocarmycins; Indoles; Kinetics; Leucomycins; Magnetic Resonance Spectroscopy; Phosphates; Pyrroles

2002
Classification of DNA-binding mode of antitumor and antiviral agents by the electrochemiluminescence of ruthenium complex.
    Analytical biochemistry, 2003, Mar-01, Volume: 314, Issue:1

    Topics: Antineoplastic Agents; Antiviral Agents; Cisplatin; Dactinomycin; Distamycins; DNA; Dose-Response Relationship, Drug; Duocarmycins; Electrochemistry; Indoles; Luminescent Measurements; Macromolecular Substances; Mitomycin; Molecular Structure; Pyrroles; Ruthenium

2003
Total synthesis of the duocarmycins.
    Journal of the American Chemical Society, 2003, Jun-04, Volume: 125, Issue:22

    Topics: Antibiotics, Antineoplastic; Duocarmycins; Indoles; Pyrroles; Pyrrolidinones; Stereoisomerism; Streptomyces

2003
Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
    Bioorganic & medicinal chemistry, 2003, Aug-15, Volume: 11, Issue:17

    Topics: Alkylation; Amides; DNA; Duocarmycins; Indoles; Kinetics; Models, Molecular; Pyrroles; Pyrrolidinones; Sulfones

2003
Nucleophilic cyclopropane ring opening in duocarmycin SA derivatives by methanol under acid conditions: a quantum mechanical study in the gas-phase and in solution.
    The Journal of organic chemistry, 2004, Apr-16, Volume: 69, Issue:8

    Topics: Antibiotics, Antineoplastic; Catalysis; Cyclopropanes; Duocarmycins; Gases; Hydrogen-Ion Concentration; Indoles; Methanol; Molecular Structure; Pyrroles; Solutions

2004
A powerful selection assay for mixture libraries of DNA alkylating agents.
    Journal of the American Chemical Society, 2004, Aug-04, Volume: 126, Issue:30

    Topics: Alkylating Agents; Alkylation; Binding, Competitive; Chromatography, High Pressure Liquid; Combinatorial Chemistry Techniques; DNA; Duocarmycins; Indoles; Pyrroles; Pyrrolidinones

2004
New synthetic method for indole-2-carboxylate and its application to the total synthesis of duocarmycin SA.
    Organic letters, 2004, Aug-19, Volume: 6, Issue:17

    Topics: Cyclization; Duocarmycins; Indoles; Molecular Structure; Pyrroles

2004
Regioselectivity and nucleophilic control in the cyclopropane ring opening of duocarmycin SA derivatives under neutral and acid conditions: a quantum mechanical study in the gas phase and in solution.
    The Journal of organic chemistry, 2004, Oct-29, Volume: 69, Issue:22

    Topics: Cyclopropanes; Duocarmycins; Indoles; Models, Molecular; Molecular Conformation; Molecular Structure; Pyridines; Pyrroles; Stereoisomerism; Thermodynamics

2004
Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.
    Bioorganic & medicinal chemistry letters, 2005, Jan-03, Volume: 15, Issue:1

    Topics: Base Sequence; Cell Line, Tumor; DNA Damage; DNA Primers; Drug Evaluation, Preclinical; Duocarmycins; Humans; Indoles; Pyrroles

2005
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
    Nature chemical biology, 2006, Volume: 2, Issue:2

    Topics: Antineoplastic Agents, Alkylating; DNA; Duocarmycins; Indoles; Nucleosomes; Pyrroles

2006
Getting under wraps: alkylating DNA in the nucleosome.
    Nature chemical biology, 2006, Volume: 2, Issue:2

    Topics: Antineoplastic Agents, Alkylating; DNA; Duocarmycins; Indoles; Nucleosomes; Pyrroles

2006
Duocarmycins binding to DNA investigated by molecular simulation.
    The journal of physical chemistry. B, 2006, Mar-02, Volume: 110, Issue:8

    Topics: Adenine; Algorithms; Alkylation; Antineoplastic Agents, Alkylating; Base Sequence; Binding Sites; Catalysis; Computer Simulation; DNA; Duocarmycins; Hydrogen Bonding; Indoles; Molecular Conformation; Oligonucleotides; Pyrroles

2006
A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2005, Volume: 1, Issue:1

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; K562 Cells; Molecular Structure; Pyrroles; Stereoisomerism

2005
Investigation of reactivity and selectivity of DNA-alkylating duocarmycin analogues by high-resolution mass spectrometry.
    Angewandte Chemie (International ed. in English), 2006, Oct-06, Volume: 45, Issue:39

    Topics: Alkylating Agents; Cell Survival; Crystallography, X-Ray; DNA; DNA Fragmentation; Duocarmycins; Electrophoresis, Polyacrylamide Gel; Indicators and Reagents; Indoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Prodrugs; Pyrroles; Spectrometry, Mass, Electrospray Ionization

2006
Antitumor agents: development of highly potent glycosidic duocarmycin analogues for selective cancer therapy.
    Angewandte Chemie (International ed. in English), 2006, Oct-06, Volume: 45, Issue:39

    Topics: Alkylating Agents; Antibodies; Cell Line, Tumor; Drug Delivery Systems; Duocarmycins; Humans; Indoles; Neoplasms; Prodrugs; Pyrroles; Streptomyces; Tumor Stem Cell Assay

2006
Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.
    Journal of the American Chemical Society, 2006, Dec-13, Volume: 128, Issue:49

    Topics: Adenine; Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Pairing; Base Sequence; DNA; Duocarmycins; Hydrogen-Ion Concentration; Indoles; Kinetics; Models, Chemical; Pyrroles; Stereoisomerism; Streptomyces; Temperature

2006
Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:16

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Lung Neoplasms; Molecular Structure; Prodrugs; Pyrroles; Stereoisomerism

2007
DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:10

    Topics: Adenine; Alkylating Agents; Alkylation; Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Cricetulus; DNA Adducts; DNA Damage; DNA Repair; Drug Evaluation, Preclinical; Duocarmycins; Humans; Indoles; Mice; Molecular Structure; Pyrroles; Saccharomyces cerevisiae; Structure-Activity Relationship; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2007
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.
    Journal of the American Chemical Society, 2007, Nov-14, Volume: 129, Issue:45

    Topics: Alkylation; Animals; Antiparasitic Agents; Cell Line, Tumor; Combinatorial Chemistry Techniques; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Design; Duocarmycins; Indoles; Injections, Intraperitoneal; Mice; Mice, Inbred DBA; Molecular Structure; Pyrroles; Stereoisomerism; Survival Rate; Xenograft Model Antitumor Assays

2007
Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
    Molecules (Basel, Switzerland), 2004, Feb-28, Volume: 9, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Cyclization; Cyclopropanes; Duocarmycins; Humans; Indoles; Pyrroles; Pyrrolidinones

2004
Cyclization of free radicals at the C-7 position of ethyl indole-2-carboxylate derivatives: an entry to a new class of Duocarmycin Analogues.
    Molecules (Basel, Switzerland), 2005, Dec-31, Volume: 10, Issue:12

    Topics: Alkylating Agents; Cyclization; Duocarmycins; Free Radicals; Indoles; Molecular Structure; Pyrroles; Quinolines

2005
Synthesis of a novel pentagastrin-drug conjugate for a targeted tumor therapy.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2008, Volume: 14, Issue:9

    Topics: Antineoplastic Agents; Catalysis; Cell Proliferation; Drug Delivery Systems; Duocarmycins; Esters; Indoles; Molecular Structure; Palladium; Pentagastrin; Pyrroles; Receptor, Cholecystokinin B

2008
Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agent.
    The Journal of infectious diseases, 2008, Feb-15, Volume: 197, Issue:4

    Topics: Alkylating Agents; Animals; Anopheles; Antimalarials; Disease Models, Animal; Duocarmycins; Female; Indoles; Mice; Oocysts; Plasmodium; Pyrroles; Sporozoites

2008
Duocarmycin-based prodrugs for cancer prodrug monotherapy.
    Bioorganic & medicinal chemistry, 2008, Jun-15, Volume: 16, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Duocarmycins; Glucuronates; Glucuronic Acid; Humans; Indoles; Inhibitory Concentration 50; Neoplasms; Prodrugs; Pyrroles

2008
Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy.
    ChemMedChem, 2008, Volume: 3, Issue:12

    Topics: Antineoplastic Agents; beta-Galactosidase; Cell Line, Tumor; Duocarmycins; Glycosides; Humans; Indoles; Inhibitory Concentration 50; Neoplasms; Prodrugs; Pyrroles; Stereoisomerism

2008
Synthesis and biological studies of different duocarmycin based glycosidic prodrugs for their use in the antibody-directed enzyme prodrug therapy.
    Journal of medicinal chemistry, 2009, Jan-22, Volume: 52, Issue:2

    Topics: Antibodies; beta-Galactosidase; Chromatography, High Pressure Liquid; Duocarmycins; Glycosides; Indoles; Magnetic Resonance Spectroscopy; Neoplasms; Prodrugs; Pyrroles; Spectrometry, Mass, Electrospray Ionization

2009
Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.
    Journal of the American Chemical Society, 2009, Jan-28, Volume: 131, Issue:3

    Topics: Alkylation; Animals; Biological Products; Cell Line, Tumor; Cell Survival; DNA; Duocarmycins; Indoles; Isomerism; Mice; Molecular Structure; Pyrroles; Solubility; Structure-Activity Relationship

2009
An additional spirocyclization for duocarmycin SA.
    Journal of the American Chemical Society, 2008, Dec-10, Volume: 130, Issue:49

    Topics: Alkylation; Antineoplastic Agents; Cyclization; Duocarmycins; Hydrogen-Ion Concentration; Indoles; Kinetics; Pyrroles

2008
Antibody-directed enzyme prodrug therapy: a promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies.
    Chemical biology & drug design, 2009, Volume: 74, Issue:3

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; beta-Galactosidase; Cell Line, Tumor; Drug Design; Duocarmycins; Glycosides; Humans; Indoles; Neoplasms; Prodrugs; Pyrroles; Stereoisomerism

2009
Synthesis and evaluation of a thio analogue of duocarmycin SA.
    Bioorganic & medicinal chemistry letters, 2009, Dec-15, Volume: 19, Issue:24

    Topics: Antineoplastic Agents, Alkylating; Duocarmycins; Indoles; Pyrroles; Sulfhydryl Compounds; Thiophenes

2009
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
    Bioorganic & medicinal chemistry letters, 2010, Mar-15, Volume: 20, Issue:6

    Topics: Alkylating Agents; Alkylation; Duocarmycins; Indoles; Oxazoles; Pyrroles

2010
Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.
    Bioorganic & medicinal chemistry letters, 2010, May-01, Volume: 20, Issue:9

    Topics: Alkylating Agents; Animals; Cell Line, Tumor; DNA; Duocarmycins; Indoles; Mice; Pyrroles; Structure-Activity Relationship

2010
Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity.
    Organic & biomolecular chemistry, 2010, Apr-21, Volume: 8, Issue:8

    Topics: Alkylating Agents; Anti-Bacterial Agents; Cell Line, Tumor; Cytostatic Agents; DNA; Duocarmycins; Humans; Indoles; Prodrugs; Pyrroles

2010
Enhanced tumor therapy using vaccinia virus strain GLV-1h68 in combination with a β-galactosidase-activatable prodrug seco-analog of duocarmycin SA.
    Cancer gene therapy, 2011, Volume: 18, Issue:1

    Topics: Animals; beta-Galactosidase; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Duocarmycins; Female; Humans; Indoles; Mice; Mice, Nude; Microscopy, Fluorescence; Oncolytic Virotherapy; Prodrugs; Pyrroles; Vaccinia virus; Xenograft Model Antitumor Assays

2011
Synthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one (CbBI) alkylation subunit.
    Journal of the American Chemical Society, 2010, Oct-06, Volume: 132, Issue:39

    Topics: Alkylation; Crystallography, X-Ray; Cyclization; Cyclobutanes; Duocarmycins; Entropy; Heterocyclic Compounds, 4 or More Rings; Indoles; Models, Molecular; Molecular Structure; Pyrroles; Stereoisomerism

2010
Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.
    Journal of medicinal chemistry, 2010, Nov-11, Volume: 53, Issue:21

    Topics: Animals; Antineoplastic Agents, Alkylating; Drug Screening Assays, Antitumor; Duocarmycins; Indoles; Leukemia L1210; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Phenols; Prodrugs; Pyrroles; Stereoisomerism; Structure-Activity Relationship

2010
Synthesis and biological evaluation of prodrugs based on the natural antibiotic duocarmycin for use in ADEPT and PMT.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Feb-07, Volume: 17, Issue:6

    Topics: Antibodies; DNA; Drug Design; Drug Screening Assays, Antitumor; Duocarmycins; Glucuronidase; Humans; Indoles; Inhibitory Concentration 50; Molecular Structure; Prodrugs; Pyrroles

2011
Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells.
    Angewandte Chemie (International ed. in English), 2012, Mar-19, Volume: 51, Issue:12

    Topics: Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents, Alkylating; Binding Sites; Cell Line, Tumor; Cell Proliferation; Duocarmycins; Humans; Indoles; Isoenzymes; Lung Neoplasms; Pyrroles; Recombinant Proteins; Retinal Dehydrogenase; Tandem Mass Spectrometry

2012
Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue.
    Molecular pharmaceutics, 2013, May-06, Volume: 10, Issue:5

    Topics: Adenoviridae; Animals; Antineoplastic Agents; Cell Line, Tumor; Duocarmycins; Extracellular Fluid; Female; Genetic Vectors; Glucuronidase; Glucuronides; Humans; Indoles; Mice; Mice, Nude; Molecular Structure; Prodrugs; Pyrroles; RNA, Small Interfering; Tumor Microenvironment; Xenograft Model Antitumor Assays

2013
A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding.
    Journal of medicinal chemistry, 2013, Sep-12, Volume: 56, Issue:17

    Topics: Animals; Antineoplastic Agents, Alkylating; Binding Sites; Cell Line, Tumor; DNA; Duocarmycins; Hydrophobic and Hydrophilic Interactions; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mice; Pyrroles; Solubility; Spectrometry, Mass, Electrospray Ionization

2013
Preparation and properties of clickable amino analogues of the duocarmycins: factors that affect the efficiency of their fluorescent labelling of DNA.
    ChemMedChem, 2014, Volume: 9, Issue:9

    Topics: Alkylation; Alkynes; Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Click Chemistry; DNA; Dogs; Drug Screening Assays, Antitumor; Duocarmycins; Fluorescent Dyes; Humans; Indoles; Pyrroles

2014
Mechanism of action of AminoCBIs: highly reactive but highly cytotoxic analogues of the duocarmycins.
    Chembiochem : a European journal of chemical biology, 2014, Sep-05, Volume: 15, Issue:13

    Topics: Animals; Antibiotics, Antineoplastic; Cricetinae; Cricetulus; Cyclopropanes; Drug Screening Assays, Antitumor; Duocarmycins; Humans; Hydrogen-Ion Concentration; Indoles; Kinetics; Mice; Protons; Pyrroles

2014
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.
    Bioorganic & medicinal chemistry, 2016, 10-15, Volume: 24, Issue:20

    Topics: Animals; Cell Line, Tumor; Cell Proliferation; Duocarmycins; Imidazoles; Indoles; Mice; Molecular Structure; Pyrroles; Stereoisomerism

2016
A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.
    Journal of medicinal chemistry, 2016, 12-22, Volume: 59, Issue:24

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; Duocarmycins; Female; Ferrous Compounds; Humans; Indoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Molecular Structure; Prodrugs; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured

2016
An Enantioselective Total Synthesis of (+)-Duocarmycin SA.
    The Journal of organic chemistry, 2018, 04-06, Volume: 83, Issue:7

    Topics: Cyclization; Duocarmycins; Hydrogenation; Indoles; Molecular Structure; Pyrroles; Stereoisomerism

2018
Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation.
    Bioorganic & medicinal chemistry letters, 2018, 09-01, Volume: 28, Issue:16

    Topics: Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Duocarmycins; Glioblastoma; Humans; Indoles; Necrosis; Protons; Pyrroles; Radiation-Sensitizing Agents

2018