Page last updated: 2024-11-04

calmagite

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Calmagite is a complex compound that is formed by the reaction of 1-(2-hydroxy-1-naphthylazo)-2-naphthol-4-sulfonic acid with magnesium and calcium ions. It is a blue-colored compound that exhibits strong fluorescence upon excitation with ultraviolet light. Calmagite is used as a chelating agent in analytical chemistry, particularly for the determination of calcium and magnesium in various samples. Its high sensitivity and selectivity towards these metals make it a valuable tool for analysis. It is also used in the pharmaceutical industry as an indicator for the pH of solutions. Calmagite is a popular reagent for studying the complexation of calcium and magnesium ions in biological systems. Researchers investigate the binding properties of calmagite to understand the role of these metals in physiological processes, such as bone formation and muscle function. Calmagite is an important tool for studying the speciation of calcium and magnesium in environmental samples. It is also used in the development of new sensors for the detection of these metals in water and soil. '

calmagite: indicator used to measure free magnesium &/or calcium in biological systems; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2530
CHEMBL ID122867
CHEMBL ID1980402
SCHEMBL ID263650
MeSH IDM0049693

Synonyms (48)

Synonym
3-hydroxy-4-((6-hydroxy-m-tolyl)azo)-1-naphthalenesulfonic acid
3-hydroxy-4-(6-hydroxy-m-tolylazo)naphthalene-1-sulphonic acid
1-naphthalenesulfonic acid, 3-hydroxy-4-((2-hydroxy-5-methylphenyl)azo)-
1-naphthalenesulfonic acid, 3-hydroxy-4-((6-hydroxy-m-tolyl)azo)-
1-naphthalenesulfonic acid, 3-hydroxy-4-(2-(2-hydroxy-5-methylphenyl)diazenyl)-
nsc 299391
0a3kvv9hzc ,
einecs 221-563-0
unii-0a3kvv9hzc
NCI60_002511
1-naphthalenesulfonic acid, 3-hydroxy-4-[(2-hydroxy-5-methylphenyl)azo]-
nsc299391
calmagite
1-naphthalenesulfonic acid, 3-hydroxy-4-[(6-hydroxy-m-tolyl)azo]-
nsc-299391
3147-14-6
calmagite, indicator grade
1-(1-hydroxy-4-methyl-2-phenylazo)-2-naphthol-4-sulfonic acid
CHEMBL122867 ,
bdbm50105944
3-hydroxy-4-(2-hydroxy-5-methyl-phenylazo)-naphthalene-1-sulfonic acid
(4z)-4-[(2-hydroxy-5-methylphenyl)hydrazinylidene]-3-oxonaphthalene-1-sulfonic acid
FT-0623426
AKOS015903174
3-hydroxy-4-(2-(2-hydroxy-5-methylphenyl)diazenyl)-1-naphthalenesulfonic acid
3-hydroxy-4-((2-hydroxy-5-methylphenyl)azo)-1-naphthalenesulfoni
calmagite [mi]
3-hydroxy-4-((2-hydroxy-5-methylphenyl)azo)-1-naphthalenesulfonic acid
SCHEMBL263650
DTXSID8062866
W-202292
CHEMBL1980402
VBRNLOQCBCPPHL-UHFFFAOYSA-N
mfcd00011656
3-hydroxy-4-(2-hydroxy-5-methylphenylazo)naphthalene-1-sulfonic acid
(e)-3-hydroxy-4-((2-hydroxy-5-methylphenyl)diazenyl)naphthalene-1-sulfonic acid
CS-8214
Q4353551
HY-D0801
AMY22381
3-hydroxy-4-[(2-hydroxy-5-methylphenyl)diazenyl]naphthalene-1-sulfonic acid
T70756
calmagite [metal indicator for ca, mg etc.]
MS-25627
1-naphthalenesulfonic acid,3-hydroxy-4-[(2-hydroxy-5-methylphenyl)azo]-
PD078506
PD078507
AKOS040744037
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thrombopoietin receptorHomo sapiens (human)EC50 (µMol)3.00000.03803.269010.0000AID210168
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (9)

Processvia Protein(s)Taxonomy
neutrophil homeostasisThrombopoietin receptorHomo sapiens (human)
monocyte homeostasisThrombopoietin receptorHomo sapiens (human)
positive regulation of lymphocyte proliferationThrombopoietin receptorHomo sapiens (human)
cellular response to hypoxiaThrombopoietin receptorHomo sapiens (human)
positive regulation of platelet formationThrombopoietin receptorHomo sapiens (human)
eosinophil homeostasisThrombopoietin receptorHomo sapiens (human)
basophil homeostasisThrombopoietin receptorHomo sapiens (human)
thrombopoietin-mediated signaling pathwayThrombopoietin receptorHomo sapiens (human)
immunoglobulin mediated immune responseThrombopoietin receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
protein bindingThrombopoietin receptorHomo sapiens (human)
thrombopoietin receptor activityThrombopoietin receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
Golgi apparatusThrombopoietin receptorHomo sapiens (human)
plasma membraneThrombopoietin receptorHomo sapiens (human)
cell surfaceThrombopoietin receptorHomo sapiens (human)
nuclear membraneThrombopoietin receptorHomo sapiens (human)
neuronal cell bodyThrombopoietin receptorHomo sapiens (human)
external side of plasma membraneThrombopoietin receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID210169Thrombopoietin luciferase activity in BAF-3 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
AID210168Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells2001Journal of medicinal chemistry, Oct-25, Volume: 44, Issue:22
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (55.56)18.7374
1990's2 (11.11)18.2507
2000's4 (22.22)29.6817
2010's1 (5.56)24.3611
2020's1 (5.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 45.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index45.80 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.68 (4.65)
Search Engine Demand Index65.84 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (45.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]