Compounds > dichapetalin a
Page last updated: 2024-12-11

dichapetalin a

Description

dichapetalin A: isolated from Dichapetalum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5469156
CHEMBL ID453157
MeSH IDM0593148

Synonyms (5)

Synonym
nsc683690
dichapetalin a
nsc-683690
CHEMBL453157
(3s,5r)-5-[(e)-3-hydroxy-2-methylprop-1-enyl]-3-[(1s,2r,3r,5r,6r,9s,14s,15r,18s,19s)-3-hydroxy-2,6,14-trimethyl-9-phenyl-8-oxahexacyclo[16.3.1.01,18.02,15.05,14.06,11]docosa-11,16-dien-19-yl]oxolan-2-one

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (32)

Assay IDTitleYearJournalArticle
AID380134Cytotoxicity against drug-resistant human KB cells in absence of vinblastine2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1707247Cytotoxicity against mouse L1210 cells2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1138649Ratio of MG132 IC50 to compound IC50 for LPS-induced nitric oxide production in mouse RAW264.7 cells2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID380139Cytotoxicity against HUVEC cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1138646Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID380138Cytotoxicity against human MCF7 cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID380137Cytotoxicity against human SKNSH cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1707251Cytotoxicity against human WM 266-4 cells incubated for 72 hrs by ATPlite assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID380132Cytotoxicity against human KB cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1138641Nematicidal activity against Panagrellus redivivus assessed as mortality at 100 ug/ml after 72 hrs by light binocular microscopic analysis (Rvb = 7.1 +/- 0.9%)2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID1707250Cytotoxicity against human Jurkat cells incubated for 72 hrs by ATPlite assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID380133Cytotoxicity against drug-resistant human KB cells in presence of vinblastine2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1138645Antifungal activity against Rhizoctonia solani at 50 ug/disc after 2 days by disk diffusion method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID1707249Cytotoxicity against human HL-60 cells incubated for 72 hrs by ATPlite assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1138642Antifungal activity against Colletotrichum gloeosporioides at 50 ug/disc after 2 days by disk diffusion method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID380130Cytotoxicity against human Lu1 cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID380131Cytotoxicity against human Col2 cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1138643Antifungal activity against Cylindrocarpon musae at 50 ug/disc after 2 days by disk diffusion method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID380140Cytotoxicity against mouse L1210 cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1707248Cytotoxicity against human HCT116 cells incubated for 72 hrs by ATPlite assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1707253Cytotoxicity against human LNCaP cells2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID380129Cytotoxicity against human BC1 cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1138648Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 20 mins prior to substrate addition measured up to 1 hr by spectrophotometric analysis relative to control2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID1138644Antifungal activity against Fusarium oxysporum f. sp. niveum at 50 ug/disc after 2 days by disk diffusion method2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID1138640Antifeedant activity against beet armyworm after 24 hrs2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID1707195Cytotoxicity against human SW626 cells2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID380136Cytotoxicity against human SW626 cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID385095Cytotoxicity against mouse L1210 cells2008Journal of natural products, Apr, Volume: 71, Issue:4
Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima.
AID380135Cytotoxicity against human LNCaP cells2006Journal of natural products, Mar, Volume: 69, Issue:3
Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.
AID1707252Cytotoxicity against human CEM cells incubated for 72 hrs by MTT assay2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
AID1138647Cytotoxicity against mouse RAW264.7 cells by MTT assay2014Journal of natural products, Apr-25, Volume: 77, Issue:4
Biologically active dichapetalins from Dichapetalum gelonioides.
AID1707200Cytotoxicity against human Lu-1 cells2020Journal of medicinal chemistry, 12-24, Volume: 63, Issue:24
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tacrine
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.		2.110acridines;
aromatic amine		EC 3.1.1.7 (acetylcholinesterase) inhibitor
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0410indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
betulinic acid
[no description available]		2.0310hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
triptonide
triptonide: extracted from Tripterygium wilfordii; structure given in first source. triptonide : A diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii.		2.2510butenolide;
cyclic ketone;
diterpene triepoxide;
organic heteroheptacyclic compound		anti-inflammatory agent;
antineoplastic agent;
immunosuppressive agent
nagilactone c
nagilactone C: norditerpene lactone isolated from leaves of Podocarpus; structure		2.2510
brusatol
brusatol: quassinoid from B. javanica; structure		2.2510triterpenoid
triptolide
[no description available]		2.2510diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound		antispermatogenic agent;
plant metabolite
parthenolide
[no description available]		2.2510germacranolide
obacunone
obacunone: from bark of Chinese plant Phellodendron amurense; shortens sleeping time induced in mice by alpha-chloralose-urethane		2.2510limonoid
chlorolissoclimide
chlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson		2.2510
bruceine a
bruceine A: quassinoid which inhibits protein synthesis & DNA synthesis in cells; RN given refers to (11 beta,12 alpha,15 beta)-isomer; structure given in first source		2.2510quassinoid
bruceine b
bruceine B: quassinoid which inhibits protein synthesis & DNA synthesis in cells; structure in first source		2.2510triterpenoid
jolkinolide a
jolkinolide A: isolated from Euphorbia fischeriana		2.2510diterpene lactonemetabolite
jolkinolide b
jolkinolide B: isolated from Euphorbia fischeriana		2.2510diterpene lactonemetabolite
limonin
[no description available]		2.2510epoxide;
furans;
hexacyclic triterpenoid;
lactone;
limonoid;
organic heterohexacyclic compound		inhibitor;
metabolite;
volatile oil component
tripdiolide
tripdiolide: structure		2.2510oxacycle
taiwanin c
taiwanin C: were isolated from the root of Acanthopanax chiisanensis; structure in first source. taiwanin C : A furonaphthodioxole that is furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one substituted by a 1,3-benzodioxol-5-yl group at position 5. It is a naturally occurring lignan extracted from Taiwania cryptomerioides and found to be a potential inhibitor of COX2 expression.		2.0410benzodioxoles;
furonaphthodioxole;
lignan		antineoplastic agent;
plant metabolite;
platelet aggregation inhibitor
thapsigargin
Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.		2.2510butyrate ester;
organic heterotricyclic compound;
sesquiterpene lactone		calcium channel blocker;
EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.		2.110amino aldehyde;
carbamate ester;
tripeptide		proteasome inhibitor
bruceantin
[no description available]		2.2510triterpenoid
3,3',4-o-trimethylellagic acid
3,7,8-tri-O-methylellagic acid: structure given in first source		2.0410tannin
andrographolide
[no description available]		2.2510carbobicyclic compound;
gamma-lactone;
labdane diterpenoid;
primary alcohol;
secondary alcohol		anti-HIV agent;
anti-inflammatory drug;
antineoplastic agent;
metabolite
shihulimonin a
shihulimonin A: isolated from Evodia rutaecarpa; structure in first source		2.2510limonoid
ginkgolide b
[no description available]		2.2510
17-hydroxyjolkinolide b
17-hydroxyjolkinolide B: isolated from Euphorbia fischeriana		2.2510diterpene lactonemetabolite
bn 52020
[no description available]		2.2510
dichlorolissoclimide
dichlorolissoclimide: structure given in first source; a labdane cytotoxin isolated from Lissoclinum voeltzkowi Michaelson		2.2510
nystatin a1
Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.		2.110nystatins
14-o-phosphonooxymethyltriptolide
14-O-phosphonooxymethyltriptolide disodium salt: pro-drug of triptolide; has antineoplastic activity		2.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.2510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.2510
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