Compounds > n(2)-phenylguanine
Page last updated: 2024-10-15

n(2)-phenylguanine

Cross-References

ID SourceID
PubMed CID135415579
CHEMBL ID287727
SCHEMBL ID1286951
SCHEMBL ID16147001
MeSH IDM0235313

Synonyms (17)

Synonym
40769-49-1
2-anilino-1,9-dihydropurin-6-one
6h-purin-6-one, 1,9-dihydro-2-(phenylamino)-
CHEMBL287727 ,
2-phenylamino-1,9-dihydro-purin-6-one
2-phenylamino-1,9-dihydro-purin-6-one (n2-phenylguanine)
bdbm50013094
6h-purin-6-one, 1,7-dihydro-2-(phenylamino)-
1,7-dihydro-2-(phenylamino)-6h-purin-6-one
n(2)-phenylguanine
SCHEMBL1286951
SCHEMBL16147001
DTXSID10193755
2-(phenylamino)-6,9-dihydro-1h-purin-6-one
phenylguanine
2-(phenylamino)-1h-purin-6(9h)-one
2-anilino-1,7-dihydropurin-6-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidine kinaseHuman alphaherpesvirus 1 strain SC16IC50 (µMol)4.77160.10001.84917.9433AID210711; AID210716
Thymidine kinase Human alphaherpesvirus 2IC50 (µMol)1.59240.10000.84621.6000AID210714; AID210715
Thymidine kinaseHuman alphaherpesvirus 1 (Herpes simplex virus type 1)IC50 (µMol)8.00000.15004.81679.0000AID210696; AID210712
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidine kinaseHuman alphaherpesvirus 1 strain SC16EC50 (µMol)8.00008.00008.00008.0000AID210529
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID210714Inhibitory activity against HSV-2 thymidine kinase isolated from HeLa cells1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
AID210711Inhibitory activity against HSV-1 thymidine kinase isolated from HeLa cells1992Journal of medicinal chemistry, Aug-07, Volume: 35, Issue:16
Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
AID210712Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 11990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
AID210715Inhibition of HSV-2 thymidine kinase, 2 uM [3H]thymidine and ATP as phosphate donor1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
AID84399Inhibition against DNA-Dependent ATPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells1995Journal of medicinal chemistry, May-12, Volume: 38, Issue:10
Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines.
AID210529Inhibitory activity against Herpes simplex virus type-I specific thymidine kinase1988Journal of medicinal chemistry, Aug, Volume: 31, Issue:8
N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.
AID1437510Inhibition of human GST-tagged CDK2/bovine His-tagged Cyclin A at 100 uM relative to untreated control2017Journal of medicinal chemistry, 03-09, Volume: 60, Issue:5
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
AID210716Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 21990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
AID210696Inhibition of HSV-1 thymidine kinase, 1 uM [3H]thymidine and ATP as phosphate donor1995Journal of medicinal chemistry, Jan-06, Volume: 38, Issue:1
Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's6 (75.00)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
nu2058
NU2058: structure in first source		2.1510
nu6102
NU6102: structure in first source		2.1510
thymidine
[no description available]		2.3920pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
2-aminopurine
2-Aminopurine: A purine that is an isomer of ADENINE (6-aminopurine).. aminopurine : Any purine having at least one amino substituent.. 2-aminopurine : The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.		2.15102-aminopurines;
nucleobase analogue		antimetabolite
o-(6)-methylguanine
O-(6)-methylguanine: structure. 6-O-methylguanine : A methylguanine in which the methyl group is positioned on the oxygen at position 6. Formed in DNA by alkylation of the oxygen atom of guanine, most often by N-nitroso compounds and sometimes due to methylation by other compounds such as endogenous S-adenosylmethionine, it base-pairs to thymine rather than cytidine, causing a G:C to A:T transition in DNA.. methylguanine : A 2-aminopurine that is guanine bearing a single methyl substituent.		2.1510methylguaninemutagen
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		1.98102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
guanine
[no description available]		2.68302-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ganciclovir
[no description available]		1.99102-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
9-(4-hydroxybutyl)guanine
[no description available]		1.9810
n(2)-(3-trifluoromethylphenyl)guanine
[no description available]		2.940
n(2)-(4-n-butylphenyl) 2'-deoxyguanosine
N(2)-(4-n-butylphenyl) 2'-deoxyguanosine: RN & structure given in first source		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials