| ID Source | ID |
|---|---|
| PubMed CID | 135512468 |
| CHEMBL ID | 79784 |
| SCHEMBL ID | 6342438 |
| MeSH ID | M0206371 |
| Synonym |
|---|
| CHEMBL79784 , |
| 2-amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one |
| bdbm50039544 |
| ci 1000 (immunosuppressant) |
| 2-amino-7-(thiophen-3-ylmethyl)-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one |
| ci-1000 |
| 2-amino-1,5-dihydro-7-(3-thienylmethyl)-4h-pyrrolo(3,2-d)pyrimidin-4-one |
| 4h-pyrrolo(3,2-d)pyrimidin-4-one, 2-amino-1,5-dihydro-7-(3-thienylmethyl)- |
| unii-tk5264yuh3 |
| pd-141955 |
| 9-deaza-9-(3-thienylmethyl)guanine |
| 132138-76-2 |
| tk5264yuh3 , |
| 2-amino-7-(3-thienylmethyl)-4-oxo-3h,5h-pyrrolo[3,2-d]pyrimidine |
| QDPMHXUWMPNTEQ-UHFFFAOYSA-N |
| SCHEMBL6342438 |
| DTXSID00157366 |
| bcx-5 |
| 4h-pyrrolo(3,2-d)pyrimidin-4-one, 2-amino-3,5-dihydro-7-(3-thienylmethyl)- |
| 2-amino-7-(3-thienylmethyl)-4-oxo-3,4-dihydro-5h-pyrrolo(3,2-d)pyrimidine |
| 2-amino-7-(thiophen-3-ylmethyl)-5h-pyrrolo[3,2-d]pyrimidin-4-ol |
| 2-amino-7-(thiophen-3-ylmethyl)-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one |
| PD129016 |
| Excerpt | Reference |
|---|---|
| " In summary, CI-1000 was well-tolerated at doses of 15, 50, and 150 mg/kg with no adverse effects occurring at 15 mg/kg." | ( Subacute toxicity of a purine nucleoside phosphorylase inhibitor in rats. Bleavins, MR; Hallak, H; Kasali, OB; Urda, E; Wolfgang, GH, 1995) |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Purine nucleoside phosphorylase | Homo sapiens (human) | Ki | 0.0600 | 0.0000 | 0.5289 | 7.0000 | AID1571174 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| nucleoside binding | Purine nucleoside phosphorylase | Homo sapiens (human) |
| purine nucleobase binding | Purine nucleoside phosphorylase | Homo sapiens (human) |
| purine-nucleoside phosphorylase activity | Purine nucleoside phosphorylase | Homo sapiens (human) |
| protein binding | Purine nucleoside phosphorylase | Homo sapiens (human) |
| phosphate ion binding | Purine nucleoside phosphorylase | Homo sapiens (human) |
| identical protein binding | Purine nucleoside phosphorylase | Homo sapiens (human) |
| guanosine phosphorylase activity | Purine nucleoside phosphorylase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| extracellular region | Purine nucleoside phosphorylase | Homo sapiens (human) |
| cytoplasm | Purine nucleoside phosphorylase | Homo sapiens (human) |
| cytosol | Purine nucleoside phosphorylase | Homo sapiens (human) |
| secretory granule lumen | Purine nucleoside phosphorylase | Homo sapiens (human) |
| extracellular exosome | Purine nucleoside phosphorylase | Homo sapiens (human) |
| ficolin-1-rich granule lumen | Purine nucleoside phosphorylase | Homo sapiens (human) |
| cytoplasm | Purine nucleoside phosphorylase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID164756 | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13 | Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. |
| AID1571174 | Inhibition of human PNP | 2018 | MedChemComm, Dec-01, Volume: 9, Issue:12 | The transition to magic bullets - transition state analogue drug design. |
| AID164764 | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using inosine as substrate at a concentration of 10 uM. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13 | Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. |
| AID229806 | Ratio of Ki ino and Kimesg against purine nucleoside phosphorylase (PNP) | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13 | Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. |
| AID229548 | Ratio of IC50 values for guanine and related hypoxanthines in PNP inhibition assay | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15 | Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines. |
| AID156068 | Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphate | 1993 | Journal of medicinal chemistry, Jan-08, Volume: 36, Issue:1 | Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. |
| AID164763 | Inhibitory activity against calf spleen purine nucleoside phosphorylase (PNP) using 2-amino-6-mercapto-7-methyl purine ribonucleoside (MESG) as substrate. | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13 | Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. |
| AID164769 | Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP) | 1994 | Journal of medicinal chemistry, Jul-22, Volume: 37, Issue:15 | Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines. |
| AID156067 | Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphate | 1993 | Journal of medicinal chemistry, Jan-08, Volume: 36, Issue:1 | Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. |
| AID229634 | Selectivity ratio is evaluated as (IC50(50 mM PO4) / IC50(1 mM PO4) | 1993 | Journal of medicinal chemistry, Jan-08, Volume: 36, Issue:1 | Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine. |
| AID229272 | Ratio of IC50 ino and Ki ino against purine nucleoside phosphorylase (PNP) | 1999 | Journal of medicinal chemistry, Jul-01, Volume: 42, Issue:13 | Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (87.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (6.25%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 15 (93.75%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||