| Assay ID | Title | Year | Journal | Article |
|---|
| AID196384 | Effective concentration evaluated in electrophysiological rat cortical slice model | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
| AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid. |
| AID92956 | Effective concentration of compound was determined for electrophysiological properties on Metabotropic glutamate receptor 1 using rat cortical slice model in Xenopus laevis oocytes | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID93126 | Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate, using radioligand [3H]- KA | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID477123 | Agonist activity at recombinant GluA2A3 receptor flop isoform expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID477119 | Agonist activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID92959 | Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 1 (GluR1) expressed in Sf 9 insect cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID168916 | In vitro binding affinity against synaptic membrane from rat brain using [3H]AMPA as the radioligand | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid. |
| AID108664 | Antagonist activity of compound at Metabotropic glutamate receptor 1 was determined | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID143462 | Binding affinity of compound was determined against N-methyl-D-aspartate glutamate receptor, using radioligand [3H]- CGP-39653 | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID108343 | In vitro binding affinity against Metabotropic glutamate receptor using [3H](S)-glutamic acid | 1998 | Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
| Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. |
| AID139966 | Neurotoxicity was determined in cultured mouse cortical neurons | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID39376 | In vitro binding affinity against synaptic membrane from rat brain using [3H](R)-Asp as the radioligand | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid. |
| AID25308 | Acid dissociation constant was calculated based on carbon atom alpha-CH | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
| AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid. |
| AID477122 | Agonist activity at recombinant GluA1A2 receptor flop isoform expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID93106 | Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 3 (GluR3) expressed in Sf 9 insect cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID477125 | Agonist activity at recombinant GluA2A4 receptor flop isoform expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID25303 | Acid dissociation constant was calculated based on carbon atom C3 | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
| AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid. |
| AID477120 | Agonist activity at recombinant GluA2 receptor flop isoform expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID477121 | Agonist activity at recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID196574 | Compound was tested for electrophysiological experiments using rat cortical wedge preparation | 1998 | Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
| Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. |
| AID175671 | Effective concentration of compound was determined for electrophysiological properties on iGluRs using rat cortical slice model in Xenopus laevis oocytes | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID93115 | Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 4 (GluR4) expressed in Sf 9 insect cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID93103 | Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 3 (GluR3) using rat cortical slice model in Xenopus laevis oocytes | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID168918 | In vitro binding affinity against synaptic membrane from rat brain using [3H]KAIN as the radioligand | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid. |
| AID179582 | In vitro binding affinity against synaptic membrane from rat brain using [3H](S)-Glu as the radioligand | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid. |
| AID477134 | Selectivity ratio of EC50 for GluA2A3 receptor to EC50 for GluA1A2 receptor | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID92965 | Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 2 (GluR2) using rat cortical slice model in Xenopus laevis oocytes | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID477133 | Agonist activity at GluA2A3 receptor | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID92944 | Binding affinity of compound was determined against Ionotropic glutamate receptor AMPA receptor, using radioligand [3H]- AMPA | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID92368 | In vitro binding affinity for Ionotropic glutamate receptor AMPA site was determined using [3H]AMPA as radioligand in rat cortex | 1997 | Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
| AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid. |
| AID477132 | Agonist activity at GluA1A2 receptor | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID477126 | Selectivity ratio of EC50 for recombinant GluA3 receptor to EC50 for recombinant GluA1 receptor expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID477124 | Agonist activity at recombinant GluA4 receptor flop isoform expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID93098 | Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor AMPA 2 (GluR2) expressed in Sf 9 insect cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID477116 | Agonist activity at recombinant GluA3 receptor expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| AID93406 | Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor ionotropic kainate 6 (GluR6) expressed in Sf 9 insect cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID92048 | Compound was tested for in vitro binding affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA ligand | 1998 | Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
| Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid. |
| AID93114 | Effective concentration of compound was determined for electrophysiological properties on Ionotropic glutamate receptor AMPA 4 (GluR4) using rat cortical slice model in Xenopus laevis oocytes | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID93257 | Binding affinity of compound was determined towards cloned Ionotropic glutamate receptor ionotropic kainate 1 (GluR5) expressed in Sf 9 insect cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
| AID477115 | Agonist activity at recombinant GluA1 receptor expressed in Xenopus oocytes | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |