Compounds > 4-bromohomoibotenic acid
Page last updated: 2024-11-10

4-bromohomoibotenic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

4-bromohomoibotenic acid: structure given in first source; RN given refers to (R)-isomer; RN for cpd without isomeric designation not available 11/89 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3082981
CHEMBL ID73069
SCHEMBL ID13957642
MeSH IDM0080565

Synonyms (15)

Synonym
5-isozaxolepropanoic acid, alpha-amino-4-bromo-2,3-dihydro-3-oxo-, (r)-
bromohomoibotenate
2-amino-3-(3-hydroxy-4-bromoisoxazol-5-yl)propanoic acid
br-hibc
121313-14-2
alpha-amino-4-bromo-3-hydroxy-5-isoxazolepropionic
brhibo
CHEMBL73069
(2r)-2-amino-3-(4-bromo-3-oxo-1,2-oxazol-5-yl)propanoic acid
(2r)-2-azaniumyl-3-(4-bromo-3-oxo-1,2-oxazol-5-yl)propanoate
4-bromohomoibotenic acid
bdbm85354
br-hibo,(r)
SCHEMBL13957642
DTXSID60153223
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Glutamate receptor 1Mus musculus (house mouse)IC50 (µMol)32.00000.04000.75502.3000AID92048
Glutamate receptor 2Mus musculus (house mouse)IC50 (µMol)32.00000.04000.75502.3000AID92048
Glutamate receptor 4Mus musculus (house mouse)IC50 (µMol)32.00000.04000.75502.3000AID92048
Glutamate receptor 3Mus musculus (house mouse)IC50 (µMol)32.00000.04000.75502.3000AID92048
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Molecular Functions (1)

Processvia Protein(s)Taxonomy
protein bindingGlutamate receptor 4Mus musculus (house mouse)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID168916In vitro binding affinity against synaptic membrane from rat brain using [3H]AMPA as the radioligand1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.
AID92048Compound was tested for in vitro binding affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA ligand1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
AID179582In vitro binding affinity against synaptic membrane from rat brain using [3H](S)-Glu as the radioligand1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.
AID39376In vitro binding affinity against synaptic membrane from rat brain using [3H](R)-Asp as the radioligand1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.
AID108343In vitro binding affinity against Metabotropic glutamate receptor using [3H](S)-glutamic acid1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
AID168918In vitro binding affinity against synaptic membrane from rat brain using [3H]KAIN as the radioligand1989Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.
AID196574Compound was tested for electrophysiological experiments using rat cortical wedge preparation1998Journal of medicinal chemistry, Mar-12, Volume: 41, Issue:6
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's5 (55.56)18.2507
2000's3 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.67 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.		1.9910non-proteinogenic alpha-amino acid
ibotenic acid
Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.		8.4980non-proteinogenic alpha-amino acidneurotoxin
2-amino-4-phosphonobutyric acid
2-amino-4-phosphonobutyric acid: glutamate antagonist in locust muscle; structure; do not confuse with L-AP4, which is the propionic acid version		2.3920
cycloleucine
Cycloleucine: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.. 1-aminocyclopentanecarboxylic acid : A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.		2.6830non-proteinogenic alpha-amino acidEC 2.5.1.6 (methionine adenosyltransferase) inhibitor
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.0210alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
quinoxalines
quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.		1.9810mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		1.97101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazoles
[no description available]		2.02101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
d-glutamate
[no description available]		1.9710D-alpha-amino acid;
glutamic acid		Escherichia coli metabolite;
mouse metabolite
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.6830glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
quisqualic acid
Quisqualic Acid: An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.		2.3920non-proteinogenic alpha-amino acid
1-amino-1,3-dicarboxycyclopentane
1-amino-1,3-dicarboxycyclopentane: RN given refers to (cis)-isomer		2.6830
4-bromohomoibotenic acid, (rs)-isomer
[no description available]		2.3920
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline: structure given in first source; neuroprotectant for cerebral ischemia; AMPA receptor antagonist		1.9810naphthalenes;
sulfonic acid derivative
ConditionIndicatedRelationship StrengthStudiesTrials