Page last updated: 2024-12-08

homoibotenic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

homoibotenic acid: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID194385
CHEMBL ID9907
SCHEMBL ID5303367
MeSH IDM0080558

Synonyms (12)

Synonym
PDSP1_001465
homoibotenic acid
PDSP2_001449
CHEMBL9907
71366-28-4
(r)-hibo
5-isoxazolepropanoic acid, alpha-amino-2,3-dihydro-3-oxo-, (+-)-
SCHEMBL5303367
alpha-amino-3-hydroxy-5-isoxazole-propionic acid
3-(3-hydroxy-1,2-oxazol-5-yl)alanine
DTXSID70991698
2-amino-3-(3-oxo-2,3-dihydroisoxazol-5-yl)propanoic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Glutamate receptor 1Rattus norvegicus (Norway rat)IC50 (µMol)1.50000.00011.617910.0000AID92368
Glutamate receptor 2Rattus norvegicus (Norway rat)IC50 (µMol)1.50000.00011.700010.0000AID92368
Glutamate receptor 3Rattus norvegicus (Norway rat)IC50 (µMol)1.50000.00011.700010.0000AID92368
Glutamate receptor 4Rattus norvegicus (Norway rat)IC50 (µMol)1.50000.00011.700010.0000AID92368
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGlutamate receptor 1Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID25305Acid dissociation constant was calculated based on carbon atom CH1997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
AID25303Acid dissociation constant was calculated based on carbon atom C31997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
AID92368In vitro binding affinity for Ionotropic glutamate receptor AMPA site was determined using [3H]AMPA as radioligand in rat cortex1997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
AID196384Effective concentration evaluated in electrophysiological rat cortical slice model1997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
AID25306Acid dissociation constant was calculated based on carbon atom CH21997Journal of medicinal chemistry, Feb-14, Volume: 40, Issue:4
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.74 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]