| Assay ID | Title | Year | Journal | Article |
|---|
| AID1317096 | Displacement of [3H]-clonidine from alpha2-AR in rat brain cortical membranes after 45 mins by liquid scintillation counting | | | |
| AID1561261 | Displacement of [3H]2-BFI from I2IR in human brain frontal cortex assessed as binding affinity at high affinity site incubated for 45 mins by liquid scintillation spectrometry | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Bicyclic α-Iminophosphonates as High Affinity Imidazoline I |
| AID91716 | Relative binding to I2 and I1 imidazoline receptors (ratio of pKi) | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| 2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors. |
| AID223237 | Binding affinity for rat imidazoline receptor I-1 from crude P2 membranes | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Binding of an imidazopyridoindole at imidazoline I2 receptors. |
| AID223238 | Displacement of [125I]p-iodoclonidine from imidazoline receptor I-1 in rat pheochromocytoma cells | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
| AID270416 | Inhibition of MAO in rat liver assessed as inhibition of [14C]tyramine oxidation at 0.1 uM | 2006 | Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
| 3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor. |
| AID1561310 | Selectivity ratio of Ki for alpha2-AR high binding site in human brain frontal cortex to Ki for I2IR high binding site in human brain frontal cortex | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Bicyclic α-Iminophosphonates as High Affinity Imidazoline I |
| AID1561258 | Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Bicyclic α-Iminophosphonates as High Affinity Imidazoline I |
| AID1317095 | Displacement of [125I]-p-iodoclonidine from I1 receptor imidazoline binding site in rat PC12 cell membranes after 30 mins by gamma counting method | | | |
| AID230911 | Relative binding to imidazoline I1 and imidazoline I2 binding sites (ratio of pKi) | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
| AID220599 | Compound was evaluated for hypotensive activity;no data | 2003 | Journal of medicinal chemistry, May-08, Volume: 46, Issue:10
| Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives. |
| AID91715 | Binding affinity for imidazoline receptor I-2 in rabbit kidney homogenate (relative to [3H]-Idazoxan radioligand) | 2000 | Journal of medicinal chemistry, Mar-23, Volume: 43, Issue:6
| 3D-QSAR CoMFA study on imidazolinergic I(2) ligands: a significant model through a combined exploration of structural diversity and methodology. |
| AID91717 | Relative binding to I2 imidazoline and alpha-2 adrenergic receptors (ratio of pKi) | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| 2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors. |
| AID230912 | Relative binding to imidazoline I2 and alpha-2 adrenergic receptors (ratio of pKi) | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
| AID270422 | Binding affinity to I2-IBS, imidazoline binding site of MAO | 2006 | Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
| 3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor. |
| AID223235 | Displacement of [125I]p-iodoclonidine from imidazoline receptor I-1 of PC12 cell membranes | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| 2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors. |
| AID1561262 | Displacement of [3H]2-BFI from I2IR in human brain frontal cortex assessed as binding affinity at low affinity site incubated for 45 mins by liquid scintillation spectrometry | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Bicyclic α-Iminophosphonates as High Affinity Imidazoline I |
| AID230913 | Relative binding to imidazoline I2 and imidazoline I1 binding sites (ratio of pKi) | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
| AID37100 | Binding affinity for rat alpha-2 adrenergic receptor from crude P2 membranes | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Binding of an imidazopyridoindole at imidazoline I2 receptors. |
| AID223251 | Displacement of [3H]idazoxan from imidazoline receptor I-2 of rabbit kidney membranes | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| 2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors. |
| AID1317094 | Displacement of [3H]idazoxan from I2 receptor imidazoline binding site in rabbit kidney membranes after 45 mins by gamma counting method | | | |
| AID223249 | Displacement of [3H]idazoxan from imidazoline receptor I-2 of rabbit kidney membranes | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
| AID35623 | Displacement of [3H]clonidine from rat cortex membrane Alpha-2 adrenergic receptors | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
| AID1561263 | Displacement of [3H]2-BFI from I2IR in human brain frontal cortex assessed as binding affinity at high affinity site incubated for 45 mins by liquid scintillation spectrometry relative to control | 2020 | Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
| Bicyclic α-Iminophosphonates as High Affinity Imidazoline I |
| AID223234 | Displacement of [125I]p-iodoclonidine from imidazoline receptor I-1 of PC12 cell membranes | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| 2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors. |
| AID270417 | Inhibition of MAO in rat liver assessed as inhibition of [14C]tyramine oxidation at 10 uM | 2006 | Journal of medicinal chemistry, Sep-07, Volume: 49, Issue:18
| 3-[5-(4,5-dihydro-1H-imidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor. |
| AID223256 | Binding affinity for rat imidazoline I2 receptor from crude P2 membranes | 2004 | Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue:2
| Binding of an imidazopyridoindole at imidazoline I2 receptors. |
| AID230910 | Relative binding to imidazoline I1 and alpha-2 adrenergic receptors (ratio of pKi) | 2003 | Journal of medicinal chemistry, May-22, Volume: 46, Issue:11
| Imidazoline binding sites (IBS) profile modulation: key role of the bridge in determining I1-IBS or I2-IBS selectivity within a series of 2-phenoxymethylimidazoline analogues. |
| AID1306517 | Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane by gamma counting method | 2016 | Bioorganic & medicinal chemistry, 07-15, Volume: 24, Issue:14
| A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin. |
| AID35631 | Displacement of [3H]-clonidine from Alpha-2 adrenergic receptor of rat cortex membranes | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| 2-(2-Phenylcyclopropyl)imidazolines: reversed enantioselective interaction at I(1) and I(2) imidazoline receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |