A2A adenosine receptor binding

Definition

Target type: molecularfunction

Binding to an A2A adenosine receptor. [GOC:mah, GOC:nln]

A2A adenosine receptors are G protein-coupled receptors (GPCRs) that bind adenosine, a nucleoside produced by the breakdown of ATP. When adenosine binds to the A2A receptor, it activates a signaling cascade that ultimately leads to the production of cAMP, a second messenger that plays a role in a wide range of cellular processes. The A2A receptor is primarily expressed in the central nervous system (CNS), where it plays a role in regulating neuronal excitability, neurotransmitter release, and synaptic plasticity. In the CNS, A2A receptors are involved in mediating a variety of physiological functions, including wakefulness, locomotion, cognition, and reward. Additionally, A2A receptors are expressed in other tissues, such as the heart, vascular smooth muscle, and immune cells, where they play a role in regulating heart rate, blood pressure, and immune function. The activation of A2A receptors can also have beneficial effects in certain disease states, such as Parkinson's disease, Alzheimer's disease, and heart failure. In summary, A2A receptor binding initiates a signaling cascade that leads to the production of cAMP, modulating various cellular processes and contributing to diverse physiological functions.'
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Proteins (2)

Compounds (53)