ambruticin: cyclopropyl-polyene-pyran acid from Polyangium cellulosum var. fulvum; RN given refers to parent cpd; structure [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 6436037 |
| PubMed CID | 6918547 |
| CHEMBL ID | 522783 |
| SCHEMBL ID | 397001 |
| MeSH ID | M0063892 |
| Synonym |
|---|
| ambruticin |
| ambruticin s |
| w-7783 , |
| w7783 , |
| ambruticin (usan/inn) |
| D02883 |
| smp-78 acid s |
| w 7783 |
| 2h-pyran-2-acetic acid, 6-(2-(2-(5-(6-ethyl-3,6-dihydro-5-methyl-2h-pyran-2-yl)-3-methyl-1,4-hexadienyl)-3-methylcyclopropyl)ethenyl)tetrahydro-4,5-dihydroxy- |
| antibiotic acid s |
| ambruticinum [inn-latin] |
| ambruticine [inn-french] |
| ambruticin [usan:inn] |
| ambruticino [inn-spanish] |
| 6-(2-(2-(5-(6-ethyl-3,6-dihydro-5-methyl-2h-pyran-2-yl)-3-methyl-1,4-hexadienyl)-3-methylcyclopropyl)vinyl)tetrahydro-4,5-dihydroxy-2h-pyran-2-acetic acid |
| nsc-328415 |
| CHEMBL522783 |
| 2-[(2s,4s,5r,6s)-6-[(e)-2-[(1s,2s,3r)-2-[(1e,3r,4e)-5-[(2r,6r)-6-ethyl-5-methyl-3,6-dihydro-2h-pyran-2-yl]-3-methylhexa-1,4-dienyl]-3-methylcyclopropyl]ethenyl]-4,5-dihydroxyoxan-2-yl]acetic acid |
| nsc 328415 |
| x794618736 , |
| ambruticine |
| unii-x794618736 |
| ambruticinum |
| ambruticino |
| 6-[2-[2-[5-(6-ethyl-3,6-dihydro-5-methyl-2h-pyran-2-yl)-3-methyl-1,4-hexadienyl]-3-methylcyclopropyl]vinyl]tetrahydro-4,5-dihydroxy-2h-pyran-2-acetic acid |
| ambruticin [usan] |
| ambruticin [inn] |
| (+)-ambruticin s |
| (+)-ambruticin |
| SCHEMBL397001 |
| Q27293636 |
| DTXSID701024202 |
| AKOS040750394 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1134945 | Antifungal activity against Microsporum fulvum assessed as growth inhibition by standard broth dilution method | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9 ISSN: 0022-2623 | Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin. |
| AID1134946 | Antifungal activity against Streptococcus pyogenes assessed as growth inhibition by standard broth dilution method | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9 ISSN: 0022-2623 | Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin. |
| AID1134944 | Antifungal activity against Histoplasma capsulatum assessed as growth inhibition by standard broth dilution method | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9 ISSN: 0022-2623 | Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin. |
| AID417426 | Elevation of Hog1 phosphorylation Saccharomyces cerevisiae ATCC 201388 carrying pYES2-HIK1 at 25 ppm after 4 hrs in SD/-Ura medium by Western blot analysis | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 ISSN: 0066-4804 | The antifungal polyketide ambruticin targets the HOG pathway. |
| AID1134909 | Antifungal activity against Candida albicans by standard broth dilution technique | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9 ISSN: 0022-2623 | Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin. |
| AID1134910 | Antifungal activity against Histoplasma capsulatum assessed as growth inhibition after 3 days by standard broth dilution technique | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9 ISSN: 0022-2623 | Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin. |
| AID1134908 | Antibacterial activity against Streptococcus pyogenes by standard broth dilution technique | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9 ISSN: 0022-2623 | Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin. |
| AID1134947 | Antifungal activity against Candida albicans assessed as growth inhibition by standard broth dilution method | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9 ISSN: 0022-2623 | Antifungal agents. 4. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Ester and amide analogues of ambruticin. |
| AID417427 | Elevation of Hog1 phosphorylation Saccharomyces cerevisiae ATCC 201388 carrying pYES2 at 25 ppm after 4 hrs in SD/-Ura medium by Western blot analysis | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 ISSN: 0066-4804 | The antifungal polyketide ambruticin targets the HOG pathway. |
| AID1134911 | Antifungal activity against Microsporum fulvum assessed as growth inhibition after 3 days by standard broth dilution technique | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9 ISSN: 0022-2623 | Antifungal agents. 5. Chemical modification of antibiotics from Polyangium cellulosum var. fulvum. Alcohol, ketone, aldehyde, and oxime analogues of ambruticin. |
| AID417300 | Elevation of Hog1 phosphorylation Saccharomyces cerevisiae ATCC 201388 carrying deltahog1 gene at 25 ppm after 4 hrs in SD/-Ura medium by Western blot analysis | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10 ISSN: 0066-4804 | The antifungal polyketide ambruticin targets the HOG pathway. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (16.67) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 14 (46.67) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (8.57%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 32 (91.43%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| vinclozolin | dicarboximide; dichlorobenzene; olefinic compound; oxazolidinone | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | ||
| fludioxonil | benzodioxoles; nitrile; organofluorine compound; pyrroles | androgen antagonist; antifungal agrochemical; estrogen receptor agonist | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aspergillosis | 0 | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Aspergillus Infection | 0 | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Coccidioides immitis Infection | 0 | 1978 | 2006 | 32.0 | medium | 0 | 1 | 0 | 1 | 0 | 0 | |
| Coccidioidomycosis | 0 | 1978 | 2006 | 32.0 | medium | 0 | 1 | 0 | 1 | 0 | 0 | |
| Dehydration | 0 | 2023 | 2023 | 1.0 | medium | 0 | 0 | 0 | 0 | 0 | 2 | |
| Disease Models, Animal | 0 | 2006 | 2006 | 18.0 | medium | 0 | 0 | 0 | 2 | 0 | 0 | |
| Fungal Lung Diseases | 0 | 1978 | 2006 | 27.3 | medium | 0 | 1 | 0 | 2 | 0 | 0 | |
| Histoplasma capsulatum Infection | 0 | 1979 | 1979 | 45.0 | low | 0 | 1 | 0 | 0 | 0 | 0 | |
| Histoplasmosis | 0 | 1979 | 1979 | 45.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| Article | Year |
|---|---|
| Investigating amine derivatives of ambruticin VS-5 and VS-4. ChemMedChem, , Volume: 3, Issue:6 | 2008 |