Compounds > fr 901464
Page last updated: 2024-11-11

fr 901464

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

FR 901464: isolated from Pseudomonas; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6448738
MeSH IDM0272899
PubMed CID10553647
CHEMBL ID494107
CHEBI ID65915
SCHEMBL ID12738778
MeSH IDM0272899

Synonyms (21)

Synonym
wb 2663b
fr-901464
fr 901464
146478-72-0
[(e,2s)-5-[[(2r,5s,6s)-6-[(2e,4e)-5-[(4r,5r,7s)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
[(e,2s)-4-[[(2r,3r,5s,6s)-6-[(2e,4e)-5-[(3r,4r,5r,7s)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]carbamoyl]but-3-en-2-yl] acetate
fr901464 ,
chebi:65915 ,
CHEMBL494107
(2s,3z)-5-{[(2r,3r,5s,6s)-6-{(2e,4e)-5-[(3r,4r,5r,7s)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methylpenta-2,4-dien-1-yl}-2,5-dimethyltetrahydro-2h-pyran-3-yl]amino}-5-oxopent-3-en-2-yl acetate
SCHEMBL12738778
LMFA08020177
Q27134411
[(z,2s)-5-[[(2r,3r,5s,6s)-6-[(2e,4e)-5-[(3r,4r,5r,7s)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] acetate
MS-29435
CS-0006188
HY-16212
(2z,4s)-4-(acetyloxy)-n-[(2r,3r,5s,6s)-6-[(2e,4e)-5-[(3r,4r,5r,7s)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2h-pyran-3-yl]-2-pentenamide
DTXSID801098397
AKOS040751857
(s,z)-5-(((2r,3r,5s,6s)-6-((2e,4e)-5-((3r,4r,5r,7s)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]octan-5-yl)-3-methylpenta-2,4-dien-1-yl)-2,5-dimethyltetrahydro-2h-pyran-3-yl)amino)-5-oxopent-3-en-2-yl acetate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
antimicrobial agentA substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
acetate esterAny carboxylic ester where the carboxylic acid component is acetic acid.
cyclic hemiketalA hemiacetal having the structure R2C(OH)OR (R =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group. The term 'cyclic hemiketals', once abandoned by IUPAC, has been reinstated as a subclass of hemiacetals.
pyrans
monocarboxylic acid amideA carboxamide derived from a monocarboxylic acid.
spiro-epoxideAn oxaspiro compound in which a carbon atom of an epoxide ring is the only common member of two rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (36)

Assay IDTitleYearJournalArticle
AID736714Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID503107Induction of p27 expression in human HeLa cells at 100 ng/ml after 16 hrs by Western blotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID441519Chemical stability in phosphate buffer assessed as half life at pH 7.4 at 37 degC2009Journal of medicinal chemistry, Nov-26, Volume: 52, Issue:22
Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.
AID1895045Cytotoxicity against human Jurkat-TAg cells assessed as cell growth inhibition measured after 48 hrs2021Journal of natural products, 05-28, Volume: 84, Issue:5
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
AID503145Induction of CDK2 in HEK293T cells transfected with FLAG-tagged p27 at 20 nM by Western blot analysis2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503102Induction of CDK4 expression in human HeLa cells at 100 ng/ml after 14 hrs by Western blotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503112Induction of truncated p27 expression in human A549 cells at 1 to 100 ng/ml after 14 hrs by immunoblotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID386628Cytotoxicity against human A549 cells after 72 hrs by XTT colorimetric assay2008Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
Antitumor compounds based on a natural product consensus pharmacophore.
AID503120Half life of the compound in culture medium by HPLC analysis2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503109Induction of p27 expression in HEK293T cells at 1 to 100 ng/ml after 14 hrs by immunoblotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID736713Antiproliferative activity against human NCI-H232A cells assessed as growth inhibition measured after 48 hrs by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID736715Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID503119Induction of truncated p27 expression in human HeLa cells at 100 ng/ml after 14 hrs in presence of 10 mM proteasome inhibitor MG1322007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503103Induction of CDK6 expression in human HeLa cells at 100 ng/ml after 14 hrs by Western blotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID736711Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID736717Stability of the compound in phosphate buffer at pH 7.4 at 37 degC by HPLC2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID1895047Inhibition of pre-mRNA splicing in human HeLa nuclear extract in presence of ATP2021Journal of natural products, 05-28, Volume: 84, Issue:5
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
AID503110Induction of truncated p27 expression in HEK293T cells at 1 to 100 ng/ml after 14 hrs by immunoblotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503144Induction of CDK2 in HEK293T cells transfected with FLAG-tagged truncated p27 at 200 nM by autoradiography2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503143Induction of CDK2 in HEK293T cells transfected with FLAG-tagged p27 at 200 nM by autoradiography2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID736718Stability of the compound in phosphate buffer at pH 7 at 37 degC by HPLC2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID386631Cytotoxicity against human MCF7 cells after 72 hrs by XTT colorimetric assay2008Journal of medicinal chemistry, Oct-09, Volume: 51, Issue:19
Antitumor compounds based on a natural product consensus pharmacophore.
AID503111Induction of p27 expression in human A549 cells at 1 to 100 ng/ml after 14 hrs by immunoblotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503114Induction of truncated p27 expression in human MCF7 cells at 1 to 100 ng/ml after 14 hrs by immunoblotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503106Induction of p16 expression in human HeLa cells at 100 ng/ml after 16 hrs by Western blotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID1895046Cytotoxicity against human MCF7 cells incubated for 7 to 10 days by MTS assay2021Journal of natural products, 05-28, Volume: 84, Issue:5
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
AID503150Induction of p27 expression in human HeLa cells at 1 to 100 ng/ml after 14 hrs by immunoblotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503113Induction of p27 expression in human MCF7 cells at 1 to 100 ng/ml after 14 hrs by immunoblotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503118Induction of p27 expression in human HeLa cells at 100 ng/ml after 14 hrs in presence of 10 mM proteasome inhibitor MG1322007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503108Induction of p21 expression in human HeLa cells at 100 ng/ml after 16 hrs by Western blotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID736712Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID503100Induction of cyclin A expression in human HeLa cells at 100 ng/ml after 14 hrs by Western blotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503147Induction of FLAG-tagged p27 expression in HEK293T cells at 100 ng/ml after 14 hrs by Western blotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID503101Induction of CDK2 expression in human HeLa cells at 100 ng/ml after 14 hrs by Western blotting2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
AID736716Stability of the compound in phosphate buffer assessed as compound remaining after 8 to 78 hrs at pH 7.4 at 37 degC by HPLC2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID503146Induction of CDK2 in HEK293T cells transfected with FLAG-tagged truncated p27 at 20 nM by Western blot analysis2007Nature chemical biology, Sep, Volume: 3, Issue:9
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (32)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (9.38)18.2507
2000's12 (37.50)29.6817
2010's13 (40.63)24.3611
2020's4 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.53 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index4.96 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials0 (0.00%)5.53%
Reviews3 (10.00%)6.00%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other27 (90.00%)84.16%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glyceric acid
glyceric acid: found in urine of patient with D-glyceric acidemia & hyperglycinaemia; RN given refers to parent cpd without isomeric designation. glycerol ether : Any ether having glyceryl as at least one of the O-substituents.. glyceric acid : A trionic acid that consists of propionic acid substituted at positions 2 and 3 by hydroxy groups.		2.4820trionic acidfundamental metabolite
threonine
Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.		2.0310amino acid zwitterion;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
threonine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
tert-butyl alcohol
tert-Butyl Alcohol: An isomer of butanol that contains a tertiary butyl group that consists of three methyl groups, each separately attached to a central (tertiary) carbon.. tert-butanol : A tertiary alcohol alcohol that is isobutane substituted by a hydroxy group at position 2.		2.4110tertiary alcoholhuman xenobiotic metabolite
propylene
propylene: structure		2.110alkene;
gas molecular entity		refrigerant;
xenobiotic
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		3.12101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.4420copper group element atom;
elemental silver		Escherichia coli metabolite
zirconium
Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.		2.4420titanium group element atom
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.		2.0210diatomic bromine
galactose
aldohexose : A hexose with a (potential) aldehyde group at one end.		3.1210
alkenes
[no description available]		3.8330
biotin
vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.		2.0210biotins;
vitamin B7		coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite
lithium
Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.		2.4110alkali metal atom
alprostadil
[no description available]		3.1210prostaglandins Eanticoagulant;
human metabolite;
platelet aggregation inhibitor;
vasodilator agent
ambruticin
ambruticin: cyclopropyl-polyene-pyran acid from Polyangium cellulosum var. fulvum; RN given refers to parent cpd; structure		3.1210
herboxidiene
herboxidiene: structure in first source; isolated from Streptomyces chromofuscus; a potent and selective herbicide (e.g. inactive against wheat); up-regulates the gene expression of LDL receptor		3.2310
lankacidins
lankacidins: RN refers to lankacidin C; RN given refers to (1S-(1R*,2S*,3E,5E,7R*,9E,11E,13R*,15S*,19S*))-isomer; structure		2.110organic molecular entity
fostriecin
fostriecin: compound contains a conjugated triene and an unsaturated lactone; from Streptomyces pulveraceus; structure given in second source. fostriecin : A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines.		3.12102-pyranones;
olefinic compound;
phosphate monoester;
polyketide;
primary allylic alcohol;
secondary allylic alcohol;
triol		antineoplastic agent;
apoptosis inhibitor;
bacterial metabolite;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
topoisomerase II inhibitor
spliceostatin a
spliceostatin A: antiangiogenic agent that blocks expression of VEGF; structure in first source		3.2150
meayamycin
meayamycin: inhibits pre-mRNA splicing; has antineoplastic activity; structure in first source		2.9940
thailanstatin a
[no description available]		2.0810C-glycosyl compound
thailanstatin b
[no description available]		2.0810
pladienolide b
pladienolide B: structure in first source		3.5420
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		3.4110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
trichostatin a
trichostatin A: chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES		2.0310antibiotic antifungal agent;
hydroxamic acid;
trichostatin		bacterial metabolite;
EC 3.5.1.98 (histone deacetylase) inhibitor;
geroprotector
ci 940
leptomycin : A complex, very long chain, polyunsaturated fatty acid whose core structure comprises 8-oxononadeca-2,10,12,16,18-pentaenoic acid having methyl substituents at positions 3, 5, 7, 9, 11 and 15 and a 3,6-dihydropyran-6-one-2-yl group at position 19.		2.0310hydroxy polyunsaturated fatty acid;
leptomycin		antifungal agent;
bacterial metabolite
spliceostatin a
spliceostatin A: antiangiogenic agent that blocks expression of VEGF; structure in first source		3.620
monomethyl auristatin e
[no description available]		3.4110
meayamycin
meayamycin: inhibits pre-mRNA splicing; has antineoplastic activity; structure in first source		3.4110
thailanstatin a
[no description available]		3.6520C-glycosyl compound
thailanstatin b
[no description available]		3.6520
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.7830
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.7830
Cancer of Lung
[description not available]		02.0510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0510
Breast Cancer
[description not available]		02.0310
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0310
Experimental Neoplasms
[description not available]		01.9910
Ascites
Accumulation or retention of free fluid within the peritoneal cavity.		01.9910