ambruticin and Disease-Models--Animal

ambruticin has been researched along with Disease-Models--Animal* in 2 studies

Other Studies

2 other study(ies) available for ambruticin and Disease-Models--Animal

Article	Year
Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:10 Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents. Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Lung Diseases, Fungal; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Pyrans; Treatment Outcome	2006
Efficacy of ambruticin analogs in a murine model of coccidioidomycosis. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:10 Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection. Topics: Animals; Antifungal Agents; Coccidioides; Coccidioidomycosis; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Lung Diseases, Fungal; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pyrans; Treatment Outcome	2006

Article

Year

Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.

Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:10

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Lung Diseases, Fungal; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Pyrans; Treatment Outcome

2006

Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.

Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:10

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

Topics: Animals; Antifungal Agents; Coccidioides; Coccidioidomycosis; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Lung Diseases, Fungal; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pyrans; Treatment Outcome

2006