| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1612408 | Substrate activity at recombinant human NQO1 assessed as ratio of Kcat to Km by measuring umol of NADPH utilized per umol of enzyme at 10 uM preincubated for 3 mins followed by NADPH addition and measured at 2 secs interval for 5 mins by Michaelis-Menten | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1612424 | Substrate activity at recombinant human NQO1 assessed as ROS generation by measuring umol of cytochrome c utilized per umol of enzyme at 10 uM co-incubated with DIC measured at 2 secs interval for 5 mins in presence of NADPH | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1891970 | Inhibition of survivin-GAL4-DBD dimerization (unknown origin) expressed in human LNCaP C4-2 cells incubated for 24 hrs by SEAP reporter based mammalian two hybrid assay | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891974 | Inhibition of survivin dimerization in human PC-3 cells assessed as survivin degradation at 1 uM incubated for 24 hrs by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1612500 | Substrate activity at recombinant human NQO1 assessed as ratio of number of equivalents of consumed NADPH to number of equivalents of test compound at 10 uM preincubated for 3 mins followed by NADPH addition and measured at 2 secs interval for 5 mins in p | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1891977 | Inhibition of survivin dimerization in human LNCaP C4-2 cells assessed as survivin degradation at 500 nM incubated for 24 hrs after 2 hrs pretreatment with proteasome inhibitor bortezomib by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1612407 | Substrate activity at recombinant human NQO1 assessed as ROS generation by measuring metabolic rate utilizing umol of NADPH per umol of enzyme at 10 uM preincubated for 3 mins followed by NADPH addition and measured at 2 secs interval for 5 mins | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1891985 | Synergistic potentiation of docetaxel-induced cytotoxicity against human LNCaP C4-2 cells assessed as combination index for reduction in cell viability at docetaxel/7F1 ratios ((1:1, 3:1, and 1:3 using their cytotoxic IC50) incubated for 72 hrs by methyle | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891969 | Cytotoxicity against human LNCaP C4-2 cells assessed as inhibition of cell survival at 2.5 uM incubated for 72 hrs by methylene blue survival assay | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891980 | Inhibition of survivin dimerization in human PC-3 cells assessed as survivin degradation at 500 nM incubated for 24 hrs after 2 hrs pretreatment with proteasome inhibitor MG132 by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1233174 | Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after 1.5 hrs by FP competitive inhibition assay | 2015 | Journal of medicinal chemistry, Jun-11, Volume: 58, Issue:11
| Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. |
| AID1891984 | Induction of apoptosis in human LNCaP C4-2 cells assessed as increase in cleaved caspase-3 level at 200 nM incubated for 24 hrs by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1459225 | Inhibition of mPGES-1 in microsomes isolated from IL-1beta-stimulated human A549 cells at 10 uM using PGH2 as substrate preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC method relative to control | 2017 | European journal of medicinal chemistry, Jan-05, Volume: 125 | Identification of novel microsomal prostaglandin E |
| AID1612410 | Cytotoxicity against human A549 cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1612411 | Cytotoxicity against NQO1 deficient human L02 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1891976 | Inhibition of survivin dimerization in human PC-3 cells assessed as survivin degradation at 500 nM incubated for 24 hrs by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1612409 | Cytotoxicity against human A549/TR cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1891978 | Inhibition of survivin dimerization in human LNCaP C4-2 cells assessed as survivin degradation at 500 nM incubated for 24 hrs after 2 hrs pretreatment with proteasome inhibitor MG132 by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891981 | Induction of apoptosis in human PC-3 cells at 200 nM incubated for 24 hrs by annexin V-FITC and propidium iodide staining based flow cytometry | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891968 | Cytotoxicity against human PC-3 cells assessed as inhibition of cell survival at 2.5 uM incubated for 72 hrs by methylene blue survival assay | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891971 | Cytotoxicity against human LNCaP C4-2 cells with survivin overexpression assessed as reduction in cell viability incubated for 72 hrs by methylene blue survival assay | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891966 | Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 72 hrs by methylene blue survival assay | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891972 | Cytotoxicity against human LNCaP C4-2 cells with empty vector-transfection assessed as reduction in cell viability incubated for 72 hrs by methylene blue survival assay | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891973 | Inhibition of survivin dimerization in human LNCaP C4-2 cells assessed as survivin degradation at 1 uM incubated for 24 hrs by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891975 | Inhibition of survivin dimerization in human LNCaP C4-2 cells assessed as survivin degradation at 500 nM incubated for 24 hrs by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1612423 | Substrate activity at recombinant human NQO1 assessed as ROS generation by measuring umol of cytochrome c utilized per umol of enzyme at 10 uM measured at 2 secs interval for 5 mins in presence of NADPH | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1612412 | Selectivity ratio of IC50 for NQO1 deficient human L02 cells to IC50 for human A549/TR cells expressing NQO1 | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1891982 | Induction of apoptosis in human LNCaP C4-2 cells at 200 nM incubated for 24 hrs by annexin V-FITC and propidium iodide staining based flow cytometry | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1612499 | Substrate activity at recombinant human NQO1 assessed as ratio of number of equivalents of consumed NADPH to number of equivalents of test compound at 10 uM preincubated for 3 mins followed by NADPH addition and measured at 2 secs interval for 5 mins by M | 2018 | Journal of medicinal chemistry, 12-27, Volume: 61, Issue:24
| Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. |
| AID1891983 | Induction of apoptosis in human PC-3 cells assessed as increase in cleaved caspase-3 level at 200 nM incubated for 24 hrs by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891986 | Synergistic potentiation of docetaxel-induced cytotoxicity against human PC-3 cells assessed as combination index for reduction in cell viability at docetaxel/7F1 ratios ((1:1, 3:1, and 1:3 using their cytotoxic IC50) incubated for 72 hrs by methylene blu | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891979 | Inhibition of survivin dimerization in human PC-3 cells assessed as survivin degradation at 500 nM incubated for 24 hrs after 2 hrs pretreatment with proteasome inhibitor bortezomib by Western blot analysis | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| AID1891967 | Cytotoxicity against human LNCaP C4-2 cells assessed as reduction in cell viability incubated for 72 hrs by methylene blue survival assay | 2022 | Bioorganic & medicinal chemistry, 07-01, Volume: 65 | A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |