Page last updated: 2024-11-13

AM2201

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-(5-fluoropentyl)-3-(1-naphthoyl)indole: a cannabimimetic; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID53393997
CHEMBL ID3526578
CHEBI ID185785
SCHEMBL ID15703451

Synonyms (37)

Synonym
chembl3526578 ,
bdbm50088439
FT-0661542
CHEBI:185785
am2201
335161-24-5
[1-(5-luoropentyl)indol-3-yl]-naphthalen-1-ylmethanone
[1-(5-fluoropentyl)-1h-indol-3-yl]-1-naphthalenylmethanone
A20540
(1-(5-fluoropentyl)-1h-indol-3-yl)(naphthalen-1-yl)methanone;am-2201
(1-(5-fluoropentyl)-1h-indol-3-yl)(naphthalen-1-yl)methanone
AKOS015950753
unii-tbj0966f1o
jwh 2201
am 2201
(1-(5-fluoropentyl)-3-(1-naphthoyl)indole)
tbj0966f1o ,
dea no. 7201
am-2201
j2.973.653g ,
methanone, (1-(5-fluoropentyl)-1h-indol-3-yl)-1-naphthalenyl-
jwh-2201
CCG-208747
1-(5-fluoropentyl)-3-(1-naphthoyl)indole
[1-(5-fluoropentyl)indol-3-yl]-naphthalen-1-ylmethanone
SCHEMBL15703451
ALQFAGFPQCBPED-UHFFFAOYSA-N
gtpl9705
DTXSID50187158
am-2201 ((1-(5-fluoropentyl)indol-3-yl)(naphthalen-1-yl)methanone) 1.0 mg/ml in acetonitrile
am-2201; (1-(5-fluoropentyl)indol-3-yl)(naphthalen-1-yl)methanone; [1-(5-fluoropentyl)-1h-indol-3-yl]-1-naphthalenylmethanone
am-2201 ((1-(5-fluoropentyl)indol-3-yl)(naphthalen-1-yl)methanone)
am-2201 ((1-(5-fluoropentyl)indol-3-yl)(naphthalen-1-yl)methanone) 0.1 mg/ml in acetonitrile
Q4652489
methanone,[1-(5-fluoropentyl)-1h-indol-3-yl]-1-naphthalenyl-
am-2201, 0.1mg/ml in methanol
am-2201, 1mg/ml in methanol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
indolecarboxamide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1211541Drug metabolism in human urine assessed as (1-(5-fluoro-4-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone formation by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211519Drug metabolism assessed as human recombinant CYP2E1-mediated (1-(5-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone formation at 10 uM after 90 mins by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211522Drug metabolism assessed as human recombinant CYP3A4-mediated (1-(5-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone formation at 10 uM after 90 mins by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211526Drug metabolism assessed as human recombinant CYP3A4-mediated (1-(5-fluoro-4-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone formation at 10 uM after 90 mins by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211525Drug metabolism assessed as human recombinant CYP2E1-mediated (1-(5-fluoro-4-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone formation at 10 uM after 90 mins by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211520Drug metabolism assessed as human recombinant CYP2E1-mediated 5-(3-(1-naphthoyl)-1H-indol-1-yl)pentanoic acid formation at 10 uM after 90 mins by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211515Activation of CB1 receptor in B6SJL mouse brain membrane assessed as [35S]-GTPgammaS binding at 10 uM after 30 mins by liquid scintillation spectrophotometric analysis in presence of O-20502012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211523Drug metabolism assessed as human recombinant CYP3A4-mediated 5-(3-(1-naphthoyl)-1H-indol-1-yl)pentanoic acid formation at 10 uM after 90 mins by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211513Displacement of [3H]CP-55,940 from CB1 receptor in B6SJL mouse brain membrane after 90 mins by liquid scintillation spectrophotometric analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211514Activation of CB1 receptor in B6SJL mouse brain membrane assessed as [35S]-GTPgammaS binding at 10 uM after 30 mins by liquid scintillation spectrophotometric analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211539Drug metabolism in human urine assessed as 5-(3-(1-naphthoyl)-1H-indol-1-yl)pentanoic acid formation by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1211540Drug metabolism in human urine assessed as (1-(5-hydroxypentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone formation by LC-MS/MS analysis2012Drug metabolism and disposition: the biological fate of chemicals, Nov, Volume: 40, Issue:11
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
AID1346701Human CB1 receptor (Cannabinoid receptors)2015ACS chemical neuroscience, Aug-19, Volume: 6, Issue:8
Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135.
AID1346728Human CB2 receptor (Cannabinoid receptors)2015ACS chemical neuroscience, Aug-19, Volume: 6, Issue:8
Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (27)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's27 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.41 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index56.46 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (39.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.70%)6.00%
Case Studies2 (7.41%)4.05%
Observational0 (0.00%)0.25%
Other24 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]