AM2201 and Seizures

AM2201 has been researched along with Seizures* in 2 studies

Reviews

1 review(s) available for AM2201 and Seizures

Article	Year
Tripping with Synthetic Cannabinoids ("Spice"): Anecdotal and Experimental Observations in Animals and Man. Current topics in behavioral neurosciences, 2017, Volume: 32 Topics: Animals; Behavior, Animal; Cannabinoids; Drug Tolerance; Humans; Hypothermia; Indoles; Mental Disorders; Naphthalenes; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders	2017

Other Studies

1 other study(ies) available for AM2201 and Seizures

Article	Year
Synthetic cannabinoid AM2201 induces seizures: Involvement of cannabinoid CB Toxicology and applied pharmacology, 2018, 01-01, Volume: 338 Abuse of synthetic cannabinoids is a serious social problem worldwide. Intentional ingestion of synthetic cannabinoids can cause severe toxicity, including seizures. Here we investigated the effects of acute administration of synthetic cannabinoids on the induction of epileptic seizures by monitoring electroencephalographic activity in freely moving mice. The synthetic cannabinoid, AM2201, induced abnormal, high-amplitude (>2-fold baseline amplitude), sharp-wave activity. The abnormal spike-wave discharges were accompanied by epileptiform behavior: rigid posture, tail extension, rearing with forepaws extended, jumping, and intermittent tonic-clonic jerking movements. The abnormal spike-wave discharges and behavioral changes were suppressed by pretreatment with the selective CB Topics: Animals; Catalepsy; Electroencephalography; Glutamic Acid; Hippocampus; Indoles; Male; Mice; Mice, Inbred ICR; Proto-Oncogene Proteins c-fos; Receptor, Cannabinoid, CB1; Seizures; Synaptic Transmission	2018

Article

Year

Synthetic cannabinoid AM2201 induces seizures: Involvement of cannabinoid CB

Toxicology and applied pharmacology, 2018, 01-01, Volume: 338

Abuse of synthetic cannabinoids is a serious social problem worldwide. Intentional ingestion of synthetic cannabinoids can cause severe toxicity, including seizures. Here we investigated the effects of acute administration of synthetic cannabinoids on the induction of epileptic seizures by monitoring electroencephalographic activity in freely moving mice. The synthetic cannabinoid, AM2201, induced abnormal, high-amplitude (>2-fold baseline amplitude), sharp-wave activity. The abnormal spike-wave discharges were accompanied by epileptiform behavior: rigid posture, tail extension, rearing with forepaws extended, jumping, and intermittent tonic-clonic jerking movements. The abnormal spike-wave discharges and behavioral changes were suppressed by pretreatment with the selective CB

Topics: Animals; Catalepsy; Electroencephalography; Glutamic Acid; Hippocampus; Indoles; Male; Mice; Mice, Inbred ICR; Proto-Oncogene Proteins c-fos; Receptor, Cannabinoid, CB1; Seizures; Synaptic Transmission

2018