Compounds > anthecotulide
Page last updated: 2024-11-12

anthecotulide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

anthecotulide: from Anthemis cotula; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AnthemisgenusA plant genus of the family ASTERACEAE that is similar to MATRICARIA but this has tiny chaffy bract scales between each pair of florets. Members contain sesquiterpene lactones. Other plants with similar common names include FERULA; FOENICULUM; MATRICARIA; CHAMAEMELUM and TRIPLEUROSPERMUM.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID11962174
CHEMBL ID478602
CHEBI ID141397
SCHEMBL ID3206793
MeSH IDM0483204

Synonyms (10)

Synonym
MEGXP0_001592
inchi=1/c15h20o3/c1-10(2)7-14(16)8-11(3)5-6-13-9-18-15(17)12(13)4/h5,7,13h,4,6,8-9h2,1-3h3/b11-5+
wsklyrkbpfvgej-vzucspmqsa-
CHEMBL478602
CHEBI:141397
anthecotulide
4-[(2e)-3,7-dimethyl-5-oxoocta-2,6-dien-1-yl]-3-methylideneoxolan-2-one
SCHEMBL3206793
4-[(2e)-3,7-dimethyl-5-oxoocta-2,6-dienyl]-3-methylideneoxolan-2-one
anthecotulid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
butan-4-olideAny gamma-lactone having the lactone moiety derived from 4-hydroxybutanoic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID378540Antimicrobial activity against Staphylococcus aureus at < 10 ug/ml2005Journal of natural products, Mar, Volume: 68, Issue:3
Anthecotulide: purification, analytical data, absence from chamomile preparations, stability and reactivity, and anti-infective testing.
AID376325Antifungal activity against Candida albicans isolate after 72 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID376322Antibacterial activity against Micrococcus luteus isolate after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID376323Antibacterial activity against Sarcina lutea ATCC 9341 after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID376324Antibacterial activity against Bacillus cereus isolate after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID376317Antibacterial activity against Agrobacterium tumefaciens A281 after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID1682376Antimicrobial activity against Escherichia coli ATCC 352182020Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli.
AID378544Antimicrobial activity against methicillin-resistant Staphylococcus aureus at < 10 ug/ml2005Journal of natural products, Mar, Volume: 68, Issue:3
Anthecotulide: purification, analytical data, absence from chamomile preparations, stability and reactivity, and anti-infective testing.
AID376315Antibacterial activity against Escherichia coli ATCC 35218 after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID376318Antibacterial activity against Pseudomonas aeruginosa isolate after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID376321Antibacterial activity against Staphylococcus aureus ATCC 6538 after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID376320Antibacterial activity against Salmonella enteritidis ATCC 13076 after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID378542Antimicrobial activity against Escherichia coli at < 10 ug/ml2005Journal of natural products, Mar, Volume: 68, Issue:3
Anthecotulide: purification, analytical data, absence from chamomile preparations, stability and reactivity, and anti-infective testing.
AID378543Antimicrobial activity against Pseudomonas aeruginosa at < 10 ug/ml2005Journal of natural products, Mar, Volume: 68, Issue:3
Anthecotulide: purification, analytical data, absence from chamomile preparations, stability and reactivity, and anti-infective testing.
AID1682377Antibacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 incubated for 7 days by microplate alamar blue assay2020Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli.
AID376319Antibacterial activity against Pseudomonas tolaasii after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID376316Antibacterial activity against Proteus mirabilis isolate after 48 hrs by serial dilution technique2006Journal of natural products, Apr, Volume: 69, Issue:4
Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity.
AID378545Antimicrobial activity against vancomycin-resistant Enterococcus faecium at < 10 ug/ml2005Journal of natural products, Mar, Volume: 68, Issue:3
Anthecotulide: purification, analytical data, absence from chamomile preparations, stability and reactivity, and anti-infective testing.
AID378541Antimicrobial activity against Enterococcus faecalis at < 10 ug/ml2005Journal of natural products, Mar, Volume: 68, Issue:3
Anthecotulide: purification, analytical data, absence from chamomile preparations, stability and reactivity, and anti-infective testing.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bay h 4502
bifonazole : A racemate comprising equimolar amounts of R- and S-bifonazole. It is a broad spectrum antifungal drug used for the treatment of fungal skin and nail infections.. 1-[biphenyl-4-yl(phenyl)methyl]imidazole : A member of the class of imidazoles carrying an alpha-(biphenyl-4-yl)benzyl substituent at position 1.		2.0310biphenyls;
imidazoles
triclosan
[no description available]		2.2510aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
streptomycin
[no description available]		2.0310antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
methyl vanillate
methyl vanillate: isolated from Hovenia dulcis. methyl vanillate : A benzoate ester that is the methyl ester of vanillic acid.		2.0310aromatic ether;
benzoate ester;
phenols		antioxidant;
plant metabolite
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		2.2510flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
xanthorrhizol
xanthorrhizol: structure in first source		2.2510sesquiterpenoid
sesquiterpenes
[no description available]		3.4570
vinaxanthone
vinaxanthone: structure given in first source		2.2510
ConditionIndicatedRelationship StrengthStudiesTrials
E coli Infections
[description not available]		02.2510
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		02.2510
Malignant Melanoma
[description not available]		07.2110
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.2110