Page last updated: 2024-12-06

tofenacin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tofenacin: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25315
CHEMBL ID2110923
CHEBI ID135046
SCHEMBL ID49290
MeSH IDM0047630

Synonyms (65)

Synonym
n-(methylamino)ethyl 2-methylbenzhydryl ether hydrochloride
n-methyl-n-(2-((2-methylphenyl)(phenyl)methoxy)ethyl)amine
n-demethylorphenadrine hydrochloride
n-methyl-2-((2-methylphenyl)(phenyl)methoxy)ethanamine
{[2-(phenyl-o-tolylmethoxy)ethyl]methylamine} hydrochloride
phenyl-(o-tolylmethyl) (methylamino)ethyl ether hydrochloride
ethylamine, {n-methyl-2-[(o-methyl-.alpha.-phenylbenzyl)oxy]-,} hydrochloride
tofacine
ethanamine, {n-methyl-2-[(2-methylphenyl)phenylmethoxy]-,} hydrochloride
{n-methyl-2-[(o-methyl-.alpha.-phenylbenzyl)oxy]ethylamine} hydrochloride
n-methyl-2-[o-tolyl(phenyl)methoxy]ethanamine
elamol
tofenacine
bs 7331 hydrochloride
nsc113809
{n-methyl-2-[.alpha.-(2-tolylbenzyl)oxy]ethylamine} hydrochloride
nsc169432
tofenacine hydrochloride
bs 7331
CHEBI:135046
tofenacin
n-methyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine
demethylorphenadrine
15301-93-6
tofenacina
tofenacine [inn-french]
einecs 239-338-0
tofenacinum [inn-latin]
tofenacinum
c4a112m10h ,
ethanamine, n-methyl-2-((2-methylphenyl)phenylmethoxy)-
tofenacina [inn-spanish]
tofenacin [inn:ban]
unii-c4a112m10h
FT-0675264
j8.547b ,
tofenacin [inn]
tofenacin [who-dd]
nororphenadrine
n-methyl-2-((o-methyl-.alpha.-phenylbenzyl)oxy)ethylamine
tofenacin [mi]
n-desmethyl orphenadrine
SCHEMBL49290
CHEMBL2110923
n-methyl-2-[(o-methyl-.alpha.-phenylbenzyl)oxy]ethylamine
ethanamine, n-methyl-2-[(2-methylphenyl)phenylmethoxy]-
PNYKGCPSFKLFKA-UHFFFAOYSA-N
n-methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine #
n-methyl-2-[(o-methyl-a-phenylbenzyl)oxy]-ethylamine
n-demethyl orphenadrine
Q7812962
DTXSID50864578
n-methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethan-1-amine
ethylamine, n-methyl-2-((o-methyl-.alpha.-phenylbenzyl)oxy)-, (+)-
ethylamine, n-methyl-2-((o-methyl-.alpha.-phenylbenzyl)oxy)-, (-)-
tofenacin, (-)-
WV5MS5T7YD ,
33431-05-9
33431-04-8
D67B6M43WW ,
tofenacin, (+)-
ethylamine, n-methyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, (-)-
unii-wv5ms5t7yd
ethylamine, n-methyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, (+)-
unii-d67b6m43ww

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Moreover, based on these results an hypothesis is put forward in order to explain the phenomenon of product inhibition, which has been suggested to occur in man under chronic orphenadrine dosing conditions."( Effect of multiple administration of orphenadrine or mono-N-desmethylorphenadrine on cytochrome P-450 catalyzed reactions in the rat.
Bast, A; Noordhoek, J; Savenije-Chapel, EM; Scheefhals, LW; van Kemenade, FA, 1983
)
0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
diarylmethaneAny compound containing two aryl groups connected by a single C atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.95 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (16.67%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (66.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]