sun-n8075 and Ocular-Hypertension

In this study, we examined the effect of SUN N8075, a radical scavenger with neuroprotective properties, on murine retinal damage induced by intravitreous injection of N-methyl-d-aspartate (NMDA) or high-intraocular pressure (IOP). In both models, systemic administration of SUN N8075 decreased the cell loss in the ganglion cell layer (GCL) after retinal damage occurred. Moreover, SUN N8075 reduced the number of apoptotic cells and the expression of an oxidative stress marker in GCL in the NMDA model. These findings suggest that SUN N8075 has a neuroprotective effect against retinal damage, presumably via the radical scavenging effect.

Topics: 8-Hydroxy-2'-Deoxyguanosine; Aniline Compounds; Animals; Cell Death; Deoxyguanosine; Disease Models, Animal; Dizocilpine Maleate; In Situ Nick-End Labeling; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Ocular Hypertension; Piperazines; Retina; Retinal Diseases; Time Factors