| Assay ID | Title | Year | Journal | Article |
|---|
| AID248949 | Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader | 2004 | Bioorganic & medicinal chemistry letters, Oct-04, Volume: 14, Issue:19
| Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2. |
| AID297277 | Displacement of [3H]spiperone from human recombinant dopamine D2 receptor | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. |
| AID443384 | Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
| Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation. |
| AID297275 | Displacement of [3H]T-226296 from rat recombinant MCH1 receptor | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. |
| AID282484 | Binding affinity to rat MCH1 receptor | 2004 | Journal of medicinal chemistry, Dec-30, Volume: 47, Issue:27
| A screening library for peptide activated G-protein coupled receptors. 1. The test set. |
| AID297276 | Displacement of [125I]HEAT from human recombinant adrenergic alpha-1A receptor | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. |
| AID297264 | Cmax in Sprague-Dawley rat at 1 mg/kg, po and 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
| AID297262 | Plasma clearance in Sprague-Dawley rat at 1 mg/kg, po and 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
| AID297266 | Tmax in Sprague-Dawley rat at 1 mg/kg, po and 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
| AID297268 | Half life in Sprague-Dawley rat at 1 mg/kg, po and 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
| AID297253 | Displacement of [3H]SNAP 7941 from rat MCHR1 expressed in HEK293 cells | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
| AID297258 | Bioavailability in Sprague-Dawley rat at 1 mg/kg, po and 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
| AID297260 | Blood clearance in Sprague-Dawley rat at 1 mg/kg, po and 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
| AID297270 | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, po and 1 mg/kg, iv | 2007 | Journal of medicinal chemistry, Aug-09, Volume: 50, Issue:16
| Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
| AID242643 | Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes | 2004 | Bioorganic & medicinal chemistry letters, Oct-04, Volume: 14, Issue:19
| Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2. |
| AID1346168 | Human MCH1 receptor (Melanin-concentrating hormone receptors) | 2002 | Nature medicine, Aug, Volume: 8, Issue:8
| Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |