neuropeptide receptor activity

Definition

Target type: molecularfunction

Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai]

Neuropeptide receptor activity encompasses the intricate molecular processes by which cells receive and interpret signals transmitted by neuropeptides. These signaling molecules, produced by neurons, play pivotal roles in regulating diverse physiological functions across the nervous system and beyond. The activity involves a series of events initiated by the binding of a neuropeptide to its cognate receptor, a transmembrane protein embedded within the cell membrane. This binding event triggers conformational changes in the receptor, leading to the activation of downstream signaling pathways. These pathways can involve a cascade of intracellular events, including alterations in protein phosphorylation, changes in ion channel permeability, and modulation of gene expression. The specific molecular mechanisms underlying neuropeptide receptor activity vary depending on the receptor type and the signaling cascade involved. However, all neuropeptide receptors share the fundamental role of converting extracellular neuropeptide signals into intracellular responses that ultimately influence cellular function and behavior. This intricate molecular machinery underpins the diverse roles of neuropeptides in regulating processes such as neurotransmission, hormone release, pain perception, appetite, and stress responses.'
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Proteins (13)

Compounds (50)