| Assay ID | Title | Year | Journal | Article |
|---|
| AID1346168 | Human MCH1 receptor (Melanin-concentrating hormone receptors) | 2002 | European journal of pharmacology, Mar-08, Volume: 438, Issue:3
| T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. |
| AID614320 | Displacement of [125I]-MCH from human MCHR1 expressed in CHO cells after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists. |
| AID551401 | Suppression of spontaneous food intake in diet-induced obese C57BL/6 mouse model at 30 mg/kg, po after 24 hrs | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2
| Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. |
| AID630087 | Displacement of [125I]-MCH(4-19) from human MCHR1 expressed in CHO cells | 2011 | Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
| Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives. |
| AID614321 | Antagonist activity at human MCHR1 expressed in CHO cells assessed as inhibition of MCH-induced GTPgammaS binding after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists. |
| AID239711 | Displacement of [125I]MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4
| Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists. |
| AID614322 | Displacement of [125I]-MCH from rat MCHR1 expressed in CHO cells after 60 mins by scintillation counting | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists. |
| AID242077 | Inhibition of Melanin-concentrating hormone 1 receptor expressed in CHO cells | 2004 | Journal of medicinal chemistry, Jul-29, Volume: 47, Issue:16
| A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor. |
| AID242643 | Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes | 2004 | Bioorganic & medicinal chemistry letters, Oct-04, Volume: 14, Issue:19
| Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2. |
| AID248949 | Concentration required to inhibit 50% of melanin-concentrating hormone induced [Ca2+] flux in IMR-32 cells measured by using a fluorometric imaging plate reader | 2004 | Bioorganic & medicinal chemistry letters, Oct-04, Volume: 14, Issue:19
| Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2. |
| AID252268 | Suppression of Melanin concentrating hormone receptor-stimulated food intake in lean rats after 30 mg/kg dose | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. |
| AID307524 | Displacement of [125I][Phe13, Tyr19]MCH from human recombinant MCHR1 expressed in CHO cells | 2007 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13
| Design and synthesis of novel hydantoin-containing melanin-concentrating hormone receptor antagonists. |
| AID443384 | Antagonist activity at CART form of human MCH1 receptor expressed in HEK293 cells coexpressing Galphaq assessed as inhibition of MCH-induced intracellular calcium level by FLIPR assay | 2009 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 19, Issue:21
| Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation. |
| AID551220 | Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay | 2011 | Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2
| Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. |
| AID614324 | Antiobesity activity in KKAy mouse assessed as inhibition of food intake at 30 mg/kg, po after 2 hrs | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists. |
| AID353587 | Antagonist activity at MCH1R by [35S]GTPgammaS binding assay | 2009 | Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7
| Novel approach for chemotype hopping based on annotated databases of chemically feasible fragments and a prospective case study: new melanin concentrating hormone antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |