snap7941 and Weight-Loss

snap7941 has been researched along with Weight-Loss* in 1 studies

Other Studies

1 other study(ies) available for snap7941 and Weight-Loss

Article	Year
Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation. Bioorganic & medicinal chemistry letters, 2009, Nov-01, Volume: 19, Issue:21 A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro. Significantly improved receptor selectivity was achieved with several analogues from this series, but no improvement in brain partitioning was noted. One example from this series was shown to inhibit food intake and decrease body weight in a chronic study. However no clear correlation between the pharmacodynamic effect and the pharmacokinetic data with respect to brain concentration was discernible leading us to conclude that the observed effect was most likely not due to interaction with the MCH-R1. Topics: Administration, Oral; Animals; Anti-Obesity Agents; Cyclohexylamines; Eating; Humans; Male; Pyrimidines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Structure-Activity Relationship; Weight Loss	2009

Article

Year

Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.

Bioorganic & medicinal chemistry letters, 2009, Nov-01, Volume: 19, Issue:21

A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro. Significantly improved receptor selectivity was achieved with several analogues from this series, but no improvement in brain partitioning was noted. One example from this series was shown to inhibit food intake and decrease body weight in a chronic study. However no clear correlation between the pharmacodynamic effect and the pharmacokinetic data with respect to brain concentration was discernible leading us to conclude that the observed effect was most likely not due to interaction with the MCH-R1.

Topics: Administration, Oral; Animals; Anti-Obesity Agents; Cyclohexylamines; Eating; Humans; Male; Pyrimidines; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Somatostatin; Structure-Activity Relationship; Weight Loss

2009