| ID Source | ID |
|---|---|
| PubMed CID | 6857723 |
| CHEMBL ID | 256877 |
| MeSH ID | M0504442 |
| Synonym |
|---|
| bz-nle-lys-arg-arg-h |
| bz-nkrr-h |
| chembl256877 , |
| bdbm33259 |
| PD193230 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " For example, 6e is an orally active inhibitor of human neutrophil elastase that entered human clinical studies, 52h is an orally bioavailable inhibitor of human chymase, and 82m is a FAAH inhibitor with in vivo endocannabinoid-enhancing activity." | ( Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Costanzo, MJ; Maryanoff, BE, 2008) | 0.35 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, nonspecifically binding compounds did not quench its fluorescence and showed similar IC(50) values with steep dose-response curves." | ( A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease. Beer, D; Bodenreider, C; Caflisch, A; Huang, D; Keller, TH; Lescar, J; Lim, SP; Otting, G; Ozawa, K; Shochat, SG; Sonntag, S; Su, XC; Vasudevan, SG; Wen, D; Yap, L; Yau, YH; Zhou, T, 2009) | 0.35 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Genome polyprotein | West Nile virus | IC50 (µMol) | 7.5000 | 0.1050 | 4.5762 | 8.9000 | AID1799226 |
| Genome polyprotein | Dengue virus 2 Thailand/NGS-C/1944 | IC50 (µMol) | 7.5000 | 1.4000 | 6.0667 | 8.9000 | AID1799226 |
| Genome polyprotein | Dengue virus 1 Nauru/West Pac/1974 | IC50 (µMol) | 7.5000 | 1.4000 | 6.0667 | 8.9000 | AID1799226 |
| Genome polyprotein | Dengue virus 2 Tonga/EKB194/1974 | IC50 (µMol) | 7.5000 | 1.4000 | 6.0667 | 8.9000 | AID1799226 |
| Genome polyprotein | Dengue virus 3 Philippines/H87/1956 | IC50 (µMol) | 7.5000 | 1.4000 | 6.0667 | 8.9000 | AID1799226 |
| Genome polyprotein | Dengue virus 2 Thailand/16681/84 | Ki | 5.8000 | 5.8000 | 5.8000 | 5.8000 | AID258359; AID258365 |
| Genome polyprotein | Dengue virus 1 Singapore/S275/1990 | IC50 (µMol) | 7.5000 | 1.4000 | 6.0667 | 8.9000 | AID1799226 |
| Genome polyprotein | Dengue virus 4 Philippines/H241/1956 | IC50 (µMol) | 7.5000 | 1.4000 | 6.0667 | 8.9000 | AID1799226 |
| Genome polyprotein | Dengue virus 3 Sri Lanka/1266/2000 | IC50 (µMol) | 7.5000 | 1.4000 | 6.0667 | 8.9000 | AID1799226 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID321229 | Inhibition of dengue virus NS3 protease | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4 | Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. |
| AID258365 | Inhibitory activity against dengue 2 NS3 protease fused via a linker to region of NS2B | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1 | Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors. |
| AID339767 | Inhibition of West Nile virus NS3 protease | 2008 | Journal of medicinal chemistry, Jul-24, Volume: 51, Issue:14 | Is quantum mechanics necessary for predicting binding free energy? |
| AID258359 | Inhibitory activity against CF40.NS3pro from Dengue virus type 2 | 2006 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1 | Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead. |
| AID271637 | Inhibition of West Nile virus NS3 protease | 2006 | Journal of medicinal chemistry, Nov-02, Volume: 49, Issue:22 | Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors. |
| AID1799226 | Enzyme Inhibition Assay from Article 10.1016/j.ab.2009.08.013: \\A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.\\ | 2009 | Analytical biochemistry, Dec-15, Volume: 395, Issue:2 | A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.41) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (16.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||