chamaejasmine profile

chamaejasmine: isolated from Stellera chamaejasmae; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Stellera	genus	[no description available]	Thymelaeaceae	A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS.[MeSH]

ID Source	ID
PubMed CID	155320
MeSH ID	M0499498

Synonym
(2r,3s)-3-[(2r,3s)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
chamaejasmine
(3,3'-bi-4h-1-benzopyran)-4,4'-dione, 2,2',3,3'-tetrahydro-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-, (2r,2'r,3s,3's)-rel-
69618-96-8
(+-)-chamaejasmine
dl-chamaejasmine
DTXSID90219886
2,2',3,3'-tetrahydro-5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-3,3'-bi[4h-1-benzopyran]-4,4'-dione
HY-N10093
CS-0255540
AKOS040763453

Excerpt	Reference	Relevance
"Chamaejasmine is a promising anti-cancer agent in OS treatment, and further studies are needed to confirm its efficacy and safety"	( The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells. Li, Z; Ma, R; Wang, K; Wu, J; Yang, D; Yang, F; Zhang, H, 2019)	1.61

Excerpt	Reference	Relevance
"Chamaejasmine treatment of MDA-MB-231 cells resulted in induction of WAF1/p21 and KIP1/p27, decrease in cyclins A and cyclins B1."	( Chamaejasmine arrests cell cycle, induces apoptosis and inhibits nuclear NF-κB translocation in the human breast cancer cell line MDA-MB-231. Bai, Y; Cai, L; Dong, G; Yu, H; Zhang, T, 2013)	2.55

Excerpt	Reference	Relevance
"91%, respectively), were separated by semi-preparative high-performance liquid chromatography combined with high-speed counter-current chromatography."	( Development of a method to screen and isolate bioactive constituents from Stellera chamaejasme by ultrafiltration and liquid chromatography combined with semi-preparative high-performance liquid chromatography and high-speed counter current chromatography Hou, W; Huang, Y; Li, S; Liu, C; Wu, T; Xia, J, 2019)	0.51

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (8.33)	29.6817
2010's	10 (83.33)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dinitrochlorobenzene Dinitrochlorobenzene: A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds.. 1-chloro-2,4-dinitrobenzene : A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.	2.21	1	C-nitro compound; monochlorobenzenes	allergen; epitope; sensitiser
3-hydroxyflavone 3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.	2.06	1	flavonols; monohydroxyflavone
lanthanum [no description available]	2.02	1	f-block element atom; lanthanoid atom; scandium group element atom
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.06	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
isopimpinellin isopimpinellin: from Ruta graveolens & Heracleum lanatum; structure	2.21	1	psoralens
astilbin astilbin: dihydroflavonol from Kohki tea processed from Engelhardtia chrysolepis (huang-qui); astilbin is the (2R-trans)-isomer; neoisoastilbin is the (2S-cis)-isomer and is Sweetening Agents; isoastilbin is the (2R-cis)-isomer; structure in first source;. astilbin : A flavanone glycoside that is (+)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.	2.06	1	3'-hydroxyflavanones; 4'-hydroxyflavanones; alpha-L-rhamnoside; flavanone glycoside; monosaccharide derivative; tetrahydroxyflavanone	anti-inflammatory agent; plant metabolite; radical scavenger
chamaejasmin chamaejasmin: from roots of Enkleia siamensis; has acetylcholinesterase inhibitory and antimalarial activities; structure in first source	2.21	1
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.02	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
neoastilbin neoastilbin: from rhizoma smilacis glabrae; structure in first source. neoastilbin : A flavanone glycoside that is (-)-taxifolin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage.	2.06	1	3'-hydroxyflavanones; 4'-hydroxyflavanones; alpha-L-rhamnoside; flavanone glycoside; monosaccharide derivative; tetrahydroxyflavanone
tacrolimus Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.. tacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.	2.21	1	macrolide lactam	bacterial metabolite; immunosuppressive agent
apigenin Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.	2.06	1	trihydroxyflavone	antineoplastic agent; metabolite
daphnoretin daphnoretin: isolated from the whole plant Wikstroemia indica. daphnoretin : A member of the class of coumarins that is coumarin substituted by a hydroxy group at position 7, a methoxy group at position 6 and a (2-oxo-2H-chromen-7-yl)oxy group at position 3.	2.21	1	aromatic ether; hydroxycoumarin	antineoplastic agent; antiviral agent; metabolite
chamaechromone chamaechromone: an anti-hepatitis B virus agent isolated from Stellera chamaejasme; structure in first source	2.21	1
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.06	1
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.21	1	benzenes; hydroxycoumarin; methyl ketone

Condition	Relationship Strength	Studies
Eczema, Atopic [description not available]	2.21	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.21	1
Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	2.21	1
Carcinoma, Non-Small Cell Lung [description not available]	2.31	1
Cancer of Lung [description not available]	2.53	2
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.31	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.53	2
Bone Cancer [description not available]	2.11	1
Osteogenic Sarcoma [description not available]	2.11	1
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	2.11	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	7.11	1
Infections, Plasmodium [description not available]	2.06	1
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	2.06	1
Benign Neoplasms [description not available]	2.06	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.06	1
Cancer of Larynx [description not available]	2.06	1
Laryngeal Neoplasms Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.	2.06	1
Adenocarcinoma, Basal Cell [description not available]	2.06	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	7.06	1
Breast Cancer [description not available]	7.08	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.08	1

chamaejasmine

Description

Cross-References

Synonyms (11)

Research Excerpts

Overview

Treatment

Compound-Compound Interactions

Research

Studies (12)

Study Types

chamaejasmine

Description

Related Flora

Cross-References

Synonyms (11)

Research Excerpts

Overview

Treatment

Compound-Compound Interactions

Research

Studies (12)

Study Types

Related Drugs (15)

Related Conditions (21)