alpha-naphthyl butyrate profile

Alpha-naphthyl butyrate (ANB) is a synthetic compound with a history of investigation in various fields. It is a derivative of butyric acid, a naturally occurring fatty acid. ANB has shown potential as a histone deacetylase (HDAC) inhibitor. HDACs are enzymes involved in gene regulation, and their inhibition can lead to changes in gene expression. In research, ANB has been explored for its potential anti-cancer effects. It has demonstrated activity against certain types of cancer cells, possibly by influencing cell cycle regulation and apoptosis. However, the exact mechanisms of action and its clinical applicability remain under investigation. ANB has also been studied for its effects on neuronal function. Some research suggests it may have neuroprotective properties, possibly by modulating neurotrophic factor expression or influencing synaptic plasticity. The specific mechanisms and therapeutic potential of ANB in neurodegenerative diseases are still being explored.'

ID Source	ID
PubMed CID	76571
SCHEMBL ID	447135
MeSH ID	M0093295

Synonym
alpha-naphthyl-n-butyrate
einecs 221-500-7
nsc 97269
9uzl9u0cik ,
ai3-18358
unii-9uzl9u0cik
1-naphthyl butyrate
nsc97269
3121-70-8
.alpha.-naphthyl butyrate
.alpha.-naphthyl-n-butyrate
nsc-97269
butanoic acid, 1-naphthalenyl ester
butyric acid, 1-naphthyl ester
AO-548/13304028
1-naphthyl butyrate, esterase substrate
B1096 ,
butyric acid 1-naphthyl ester
alpha-naphthyl butyrate
naphthalen-1-yl butanoate
AKOS024348853
FT-0608120
naphthalen-1-yl butyrate
SCHEMBL447135
DTXSID9062851
n-butyric acid .alpha.-naphthyl ester
XIVJNRXPRQKFRZ-UHFFFAOYSA-N
mfcd00003923
AS-58219
naphthyl butyrate
1,1-biphenyl,3-(chloromethyl)-
Q27273258
D88751
naphthalen-1-ylbutyrate

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (66.67)	18.7374
1990's	2 (13.33)	18.2507
2000's	2 (13.33)	29.6817
2010's	1 (6.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (6.25%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	2.17	1	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
malathion Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.	2.05	1	diester; ethyl ester; organic thiophosphate
butyl phosphorotrithioate butyl phosphorotrithioate: a herbicide	2.05	1	organic thiophosphate	defoliant
sodium fluoride [no description available]	2.37	2	fluoride salt	mutagen
iodoacetic acid Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.. iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.	1.96	1	haloacetic acid; organoiodine compound	alkylating agent
isoflurophate Isoflurophate: A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.	2.37	2	dialkyl phosphate
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	1.96	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	1.96	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
3,3'-diaminobenzidine 3,3'-Diaminobenzidine: A chemically and thermodynamically stable derivative of BENZIDINE.. 3,3'-diaminobenzidine : A member of the class of biphenyls that is benzidine in which one of the hydrogens ortho to each of the amino groups has been replaced by an amino group.	1.96	1	biphenyls; substituted aniline	histological dye
benzidine benzidine: RN given refers to parent cpd. benzidine : A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group.	1.96	1	biphenyls; substituted aniline	carcinogenic agent
3-amino-9-ethylcarbazole 3-amino-9-ethylcarbazole: RN given refers to parent cpd	1.96	1	carbazoles
2-naphthol 2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.	4.05	15	naphthol	antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger
ethyl acrylate [no description available]	1.98	1	enoate ester
thiamine pyrophosphate Thiamine Pyrophosphate: The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.. thiamine(1+) diphosphate chloride : An organic chloride salt of thiamine(1+) diphosphate.	2.05	1	organic chloride salt; vitamin B1
c.i. 42510 Rosaniline Dyes: Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.. basic fuchsin : A four-component mixture of chemically related dyes comprising pararosanilin, rosanilin, magenta II and new fuchsin in varying amounts. rosanilin : A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the major constituents of Basic fuchsin, together with pararosanilin, magenta II and new fuchsin.	2.66	3
naphthyl acetate naphthyl acetate: do not confuse with naphthaleneacetic acid; acetic acid ester of naphthol	3.23	6
methiocarb Methiocarb: Insecticide, molluscacide, acaricide.. methiocarb : A carbamate ester obtained by the formal condensation of the phenolic group of 3,5-dimethyl-4-(methylsulfanyl)phenol with the carboxy group of methylcarbamic acid.	2.04	1	aryl sulfide; carbamate ester; methyl sulfide	acaricide; agrochemical; avicide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; environmental contaminant; insecticide; molluscicide; xenobiotic
o,o-diethyl o-3,5,6-trichloro-2-pyridyl phosphate [no description available]	2.17	1
fast blue bb Fast Blue BB: RN given refers to parent cpd	2.66	3
leupeptin [no description available]	1.96	1	aldehyde; tripeptide	bacterial metabolite; calpain inhibitor; cathepsin B inhibitor; EC 3.4.21.4 (trypsin) inhibitor; serine protease inhibitor
naphthol as-bi phosphate naphthol AS-BI phosphate: RN given refers to parent cpd	1.96	1
4-nitrophenyl butyrate p-nitrophenyl butyrate : A butyrate ester resulting from the formal condensation of the hydroxy group of 4-nitrophenol with the carboxy group of butyric acid.	2.39	2	butyrate ester; C-nitro compound
naphthol as-d chloroacetate [no description available]	2.37	2
leupeptins Leupeptins: A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.	1.96	1
alpha-chymotrypsin Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.	1.96	1
acrinathrin acrinathrin: structure in first source	2.04	1	cyclopropanecarboxylate ester; organofluorine compound	pyrethroid ester acaricide; pyrethroid ester insecticide
acid phosphatase Acid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.	1.96	1
new fuchsin new fuchsin : A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the minor constituents of Basic fuchsin, together with pararosanilin, rosanilin and magenta II.	1.96	1	hydrochloride	fluorochrome; histological dye
chymostatin [no description available]	1.96	1
pyrethrins [no description available]	2.04	1
albicidin albicidin: partially characterized as a 38 carbon compound with several aromatic rings; from Xanthomonas albilineans; Albicidin blocked DNA synthesis in intact cells of a PolA- EndA- Escherichia coli strain; albicidin resistance gene (albB) from Alcaligenes denitrificans encodes a 23 kDa protein capable of detoxifying albicidin by reversible binding	1.99	1

Condition	Relationship Strength	Studies
Acute Myelogenous Leukemia [description not available]	2.65	3
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.65	3
Abnormalities, Autosome [description not available]	1.96	1
Leukemia, Acute Monocytic [description not available]	1.96	1
Leukemia, Monocytic, Acute An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.	1.96	1
Leukemia, Lymphocytic [description not available]	2.37	2
Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	2.37	2
Leukocytopenia [description not available]	1.96	1
Diseases, Occupational [description not available]	1.96	1
Leukopenia A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).	1.96	1
Leucocythaemia [description not available]	1.96	1
Acute Disease Disease having a short and relatively severe course.	1.96	1
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	1.96	1

alpha-naphthyl butyrate

Cross-References

Synonyms (34)

Research

Studies (15)

Market Indicators

Research Demand Index: 30.09

Study Types