s 53482 profile

flumioxazin : A benzoxazine that is N-(prop-2-yn-1-yl)-2H-1,4-benzoxazin-3(4H)-one which is substituted at position 6 by a 1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl group and at position 7 by a fluorine. A protoporphyrinogen oxidase inhibitor, it is used for the control of weeds in soya, peanuts, and a variety of vegetable and fruit crops. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	92425
CHEMBL ID	2133606
CHEBI ID	8939
SCHEMBL ID	39699
MeSH ID	M0384697

Synonym
s 53482
einecs annex i index 613-166-00-x
hsdb 7012
v 53482
1h-isoindole-1,3(2h)-dione, 4,5,6,7-tetrahydro-2-(7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2h-1,4-benzoxazin-6-yl)-
sumisoya
7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4-(2-propynyl)-1,4-benzoxazin-3(2h)-one
flumioxazin [iso]
103361-09-7
flumioxazin
s-53482
NCGC00163707-01
2-(7-fluoro-3-oxo-4-prop-2-yn-1-yl-3,4-dihydro-2h-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione
NCGC00163707-02
2-(7-fluoro-3-oxo-4-prop-2-ynyl-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydroisoindole-1,3-dione
NCGC00163707-03
cas-103361-09-7
tox21_301061
dtxcid5012555
dtxsid7032555 ,
NCGC00254963-01
unii-l0px7ogi22
7-fluoro-6-((3,4,5,6-tetrahydro)phthalimido)-4-(2-propynyl)-1,4-benzoxazin-3(2 h)-one
l0px7ogi22 ,
2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propyn-1-yl)-2h-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione
flumioxazine
FT-0631025
AKOS015903850
valor
n-(7-fluoro-3,4-dihydro-3-oxo-4-prop-2-ynyl-2h-1,4-benzoxazin-6-yl)cyclohex-1-ene-1,2-dicarboxamide
flumioxazin [hsdb]
2-(7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2h-1,4-benzoxazin-6-yl)-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione
flumioxazin [mi]
v-53482
SCHEMBL39699
CHEMBL2133606
chebi:8939 ,
2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2h-1,4-benzoxazine-6-yl]-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione
2-[7-fluoro-4-(2-propynyl)-2h-1,4-benzoxazin-3(4h)-on-6-yl]-4,5,6,7-tetrahydro-2h-isoindole-1,3-dione
2-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2h-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione
AC-33640
sumisoya; v 53482
2-[7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2h-1,4-benzoxazin-6-yl]-2,3,4,5,6,7-hexahydro-1h-isoindole-1,3-dione
flumioxazin, pestanal(r), analytical standard
bdbm50487098
2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2h-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione, 9ci
fluminoxazin
2-(7-fluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2h-benzo[b][1,4]oxazin-6-yl)-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione
2-[7-fluoro-3,4-dihydro-3-oxo-4-(prop-2-yn-1-yl)-2h-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione
HY-114507
Q1434160
CS-0063339
AMY3526
1h-isoindole-1,3(2h)-dione,2-[7-fluoro-3,4-dihydro-3-oxo-4-(2-propynyl)-2h-1,4-benzoxazin-6-yl]-4,5,6,7-tetrahydro-
v53482
s53482
2-(7-fluoro-3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazin-6-yl)-4,5,6,7-tetrahydro-1h-isoindole-1,3(2h)-dione
flumioxazin 10 microg/ml in acetonitrile
flumioxazin 10 microg/ml in cyclohexane

Excerpt	Reference	Relevance
"S-53482, 7-fluoro-6-[(3,4,5,6-tetrahydro)phthalimido]-4-(2-propynyl)-1,4-benzoxazin-3(2H)-one (flumioxazin), is an N-phenylimide herbicide and developmentally toxic to rats, but not to rabbits."	( Close link between protoporphyrin IX accumulation and developmental toxicity induced by N-phenylimide herbicides in rats. Fantel, AG; Kato, T; Kawamura, S, 2014)	0.4
"The developmentally toxic compounds caused PPIX accumulation in embryos."	( Close link between protoporphyrin IX accumulation and developmental toxicity induced by N-phenylimide herbicides in rats. Fantel, AG; Kato, T; Kawamura, S, 2014)	0.4
" A series of studies to investigate the effects of flumioxazin have revealed that developmental toxicity is caused in rats but not in rabbits, and the adverse effects are not likely to occur in humans."	( Lack of human relevance for rat developmental toxicity of flumioxazin is revealed by comparative heme synthesis assay using embryonic erythroid cells derived from human and rat pluripotent stem cells. Asano, K; Fukuda, T; Kitamoto, S; Otani, M; Takahashi, Y; Tomigahara, Y; Ueno, M, 2022)	0.72

Excerpt	Reference	Relevance
"A physiologically based pharmacokinetic (PBPK) model was developed to predict the concentration of flumioxazin, in the blood and fetus of pregnant humans during a theoretical accidental intake (1000mg/kg)."	( Metabolism and physiologically based pharmacokinetic modeling of flumioxazin in pregnant animals. Nagahori, H; Sogame, Y; Takaku, T, 2014)	0.4

Excerpt	Reference	Relevance
" Because the metabolism was not saturated and the absorption rate was low at a dose of 1000mg/kg, the calculated flumioxazin concentration in pregnant humans was thought to be relatively low, considering the flumioxazin concentration in pregnant rats at a dose of 30mg/kg."	( Metabolism and physiologically based pharmacokinetic modeling of flumioxazin in pregnant animals. Nagahori, H; Sogame, Y; Takaku, T, 2014)	0.4

Excerpt	Relevance	Reference
" (14)C recoveries (expressed as percentages relative to the dosed (14)C) in feces and urine were 56-72 and 31-43%, respectively, for the low dose and 78-85 and 13-23%, respectively, for the high dose."	( Metabolism of 7-fluoro-6-(3,4,5,6-tetrahydrophthalimido)-4- (2-propynyl)-2H-1,4-benzoxazin-3(4H)-one (S-53482) in rat. 1. Identification of a sulfonic acid type conjugate. Isobe, N; Kaneko, H; Matsui, M; Matsunaga, H; Nakatsuka, I; Tomigahara, Y; Yamane, S; Yoshitake, A, 1999)	0.3
"As part of its development, the new synthetic trioxolane antimalarial artefenomel (OZ439) was tested in rat whole embryo culture and in rat embryo-fetal toxicity studies with dosing throughout organogenesis or with a single dose on Gestational Day (GD) 12."	( Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate. Andenmatten, N; Clark, RL; Clode, SA; Edwards, TL; Huber, AC; Kinney, J; Longo, M; Rhodes, J; Rückle, T; Walker, DK; Wells, T, 2018)	0.48

Role	Description
herbicide	A substance used to destroy plant pests.
agrochemical	An agrochemical is a substance that is used in agriculture or horticulture.
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor	An EC 1.3.3.* (oxidoreductase acting on donor CH-CH group with oxygen as acceptor) inhibitor that interferes with the action of protoporphyrinogen oxidase (EC 1.3.3.4).
teratogenic agent	A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
benzoxazine
terminal acetylenic compound	An acetylenic compound which a carbon of the C#C moiety is attached to a hydrogen atom.
dicarboximide	An imide in which the two acyl substituents on nitrogen are carboacyl groups.
organofluorine compound	An organofluorine compound is a compound containing at least one carbon-fluorine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	21.7856	0.0060	38.0041	19,952.5996	AID1159521; AID1159523
GLI family zinc finger 3	Homo sapiens (human)	Potency	9.1870	0.0007	14.5928	83.7951	AID1259369; AID1259392
AR protein	Homo sapiens (human)	Potency	61.7653	0.0002	21.2231	8,912.5098	AID743042; AID743063
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	34.5107	0.0010	22.6508	76.6163	AID1224838; AID1224839; AID1224893
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	41.5867	0.0015	30.6073	15,848.9004	AID1224841; AID1224848; AID1224849; AID1259401; AID1259403
pregnane X nuclear receptor	Homo sapiens (human)	Potency	68.5896	0.0054	28.0263	1,258.9301	AID1346982
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	40.9891	0.0006	27.2152	1,122.0200	AID651741; AID743202; AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Protoporphyrinogen oxidase	Zea mays	IC50 (µMol)	0.0032	0.0032	0.0032	0.0032	AID1091455
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (162)

Assay ID	Title	Year	Journal	Article
AID1080885	Post-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 7.5 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080884	Post-emergence herbicidal activity against Setaria viridis (green foxtail) assessed as growth inhibition at 7.5 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080895	Pre-emergence herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as growth inhibition at 7.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103493	Herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as weed growth inhibition at post-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103467	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 150 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1091483	Herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as inhibition of fresh weed plant weight at 187.5 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080862	Post-emergence herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as growth inhibition at 37.5 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080836	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 37.5 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103492	Herbicidal activity against crabgrass Digitaria sanguinalis(hairy crabgrass) assessed as weed growth inhibition at post-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080842	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 300 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080886	Post-emergence herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as growth inhibition at 7.5 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080847	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 75 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080896	Post-emergence herbicidal activity against Setaria viridis (green foxtail) assessed as growth inhibition at 75 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080843	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 75 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103451	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 15 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103501	Herbicidal activity against Echinochloa crus-galli (barnyard grass) (barnyard grass) assessed as weed growth inhibition at 75 g/ha pre-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080829	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 7.5 to 60 g.a.i/ha post-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080871	Pre-emergence herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as growth inhibition at 37.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080879	Pre-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 15 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080880	Pre-emergence herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as growth inhibition at 15 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080902	Pre-emergence herbicidal activity against Setaria viridis (green foxtail) assessed as growth inhibition at 75 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103448	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 30 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103499	Herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as weed growth inhibition at 75 g/ha post-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080833	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 300 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080868	Pre-emergence herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as growth inhibition at 37.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1091444	Herbicidal activity against Brassica rapa subsp. oleifera assessed as inhibition of fresh weed plant weight at 45 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1091445	Herbicidal activity against Brassica rapa subsp. oleifera assessed as inhibition of fresh weed plant weight at 93.75 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080890	Pre-emergence herbicidal activity against Setaria viridis (green foxtail) assessed as growth inhibition at 7.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103483	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 15 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1091486	Herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as inhibition of fresh weed plant weight at 22.5 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080891	Pre-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 7.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103502	Herbicidal activity against crabgrass Digitaria sanguinalis(hairy crabgrass) assessed as weed growth inhibition at 75 g/ha pre-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080865	Pre-emergence herbicidal activity against Setaria viridis (green foxtail) assessed as growth inhibition at 37.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080846	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 300 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103455	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 15 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103450	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 15 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103468	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 75 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080883	Pre-emergence herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as growth inhibition at 15 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103456	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 7.5 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103494	Herbicidal activity against Setaria viridis (green foxtail) assessed as weed growth inhibition at 75 g/ha post-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103460	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 7.5 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080832	Phytotoxicity against Arachis hypogaea (peanut) assessed as growth inhibition at 7.5 to 60 g.a.i/ha post-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1091468	Herbicidal activity against Amaranthus retroflexus assessed as inhibition of fresh weed plant weight at 45 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080851	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 75 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080855	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 37.5 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1091484	Herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as inhibition of fresh weed plant weight at 93.75 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080826	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 7.5 to 60 g.a.i/ha post-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080828	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 7.5 to 60 g.a.i/ha post-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103466	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 150 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1091443	Herbicidal activity against Brassica rapa subsp. oleifera assessed as inhibition of fresh weed plant weight at 22.5 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080866	Post-emergence herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as growth inhibition at 37.5 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103486	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 7.5 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103469	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 75 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1091446	Herbicidal activity against Brassica rapa subsp. oleifera assessed as inhibition of fresh weed plant weight at 187.5 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1091455	Inhibition of protoporphyrinogen oxidase in Zea mays (maize) seedlings leaves etioplasts using protoporphyrinogen IX incubated for 30 min by fluorescence spectroscopy	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1091461	Herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as inhibition of fresh weed plant weight at 187.5 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080881	Pre-emergence herbicidal activity against Amaranthus spinosus assessed as growth inhibition at 15 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103488	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 7.5 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103474	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 30 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103465	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 150 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103461	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 7.5 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080899	Post-emergence herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as growth inhibition at 75 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080839	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 150 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103479	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 15 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103485	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 15 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103496	Herbicidal activity against crabgrass Digitaria sanguinalis(hairy crabgrass) assessed as weed growth inhibition at 75 g/ha post-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080837	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 300 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103498	Herbicidal activity against fat hen Chenopodium album assessed as weed growth inhibition at 75 g/ha post-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080873	Post-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 15 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103487	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 7.5 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080900	Post-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 75 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080849	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 37.5 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080827	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 7.5 to 60 g.a.i/ha post-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080903	Pre-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 75 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080848	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 300 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103453	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 15 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103491	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 7.5 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103464	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 150 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103462	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 150 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103473	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 75 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080875	Post-emergence herbicidal activity against Amaranthus spinosus assessed as growth inhibition at 15 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080852	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 300 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080907	Pre-emergence herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as growth inhibition at 75 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080834	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 75 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080860	Post-emergence herbicidal activity against Setaria viridis (green foxtail) assessed as growth inhibition at 37.5 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103470	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 75 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103471	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 75 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103457	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 7.5 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080893	Pre-emergence herbicidal activity against Amaranthus spinosus assessed as growth inhibition at 7.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080877	Post-emergence herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as growth inhibition at 15 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103475	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 30 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103481	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 15 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103444	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 30 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080889	Post-emergence herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as growth inhibition at 7.5 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080831	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 7.5 to 60 g.a.i/ha post-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080840	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 37.5 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080864	Post-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 37.5 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103497	Herbicidal activity against Amaranthus blitum assessed as weed growth inhibition at 75 g/ha post-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080853	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 37.5 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103445	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 30 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103459	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 7.5 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080858	Phytotoxicity against Arachis hypogaea (peanut) assessed as growth inhibition at 150 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080838	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 75 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103484	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 15 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080874	Post-emergence herbicidal activity against Digitaria sanguinalis(hairy crabgrass) assessed as growth inhibition at 15 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080830	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 7.5 to 60 g.a.i/ha post-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080872	Post-emergence herbicidal activity against Setaria viridis (green foxtail) assessed as growth inhibition at 15 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080841	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 150 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103454	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 15 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103477	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 30 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103503	Herbicidal activity against Amaranthus blitum assessed as weed growth inhibition at 75 g/ha pre-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103490	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 7.5 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080887	Post-emergence herbicidal activity against Amaranthus spinosus assessed as growth inhibition at 7.5 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080905	Pre-emergence herbicidal activity against Amaranthus ascendens assessed as growth inhibition at 75 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080863	Post-emergence herbicidal activity against Amaranthus spinosus assessed as growth inhibition at 37.5 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080825	Phytotoxicity against Arachis hypogaea (peanut) assessed as growth inhibition at 37.5 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080892	Pre-emergence herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as growth inhibition at 7.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080870	Pre-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 37.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080882	Pre-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 15 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080845	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 150 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080898	Post-emergence herbicidal activity against Amaranthus ascendens assessed as growth inhibition at 75 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103446	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 30 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080897	Post-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 75 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080894	Pre-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 7.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103480	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 30 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103472	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 75 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080867	Pre-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 37.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103463	Phytotoxicity against Triticum aestivum (wheat) assessed as growth inhibition at 150 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080856	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 75 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103476	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 30 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103495	Herbicidal activity against Echinochloa crus-galli (barnyard grass) (barnyard grass) assessed as weed growth inhibition at 75 g/ha post-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103458	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 7.5 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1091463	Herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as inhibition of fresh weed plant weight at 45 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1103505	Herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as weed growth inhibition at 75 g/ha pre-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103478	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 30 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080904	Pre-emergence herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as growth inhibition at 75 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1091467	Herbicidal activity against Amaranthus retroflexus assessed as inhibition of fresh weed plant weight at 93.75 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080878	Pre-emergence herbicidal activity against Setaria viridis (green foxtail) assessed as growth inhibition at 15 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103489	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 7.5 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1091462	Herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as inhibition of fresh weed plant weight at 93.75 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1103449	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 30 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080861	Post-emergence herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as growth inhibition at 37.5 g.a.i./ha applied at one-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080906	Pre-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 75 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080869	Pre-emergence herbicidal activity against Amaranthus spinosus assessed as growth inhibition at 37.5 g.a.i./ha applied 24 hr after seeds were sown measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103500	Herbicidal activity against Setaria viridis (green foxtail) assessed as weed growth inhibition at 75 g/ha pre-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1091485	Herbicidal activity against Echinochloa crus-galli (barnyard grass) assessed as inhibition of fresh weed plant weight at 45 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080835	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 150 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080844	Phytotoxicity against Zea mays (maize) assessed as growth inhibition at 37.5 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1091466	Herbicidal activity against Amaranthus retroflexus assessed as inhibition of fresh weed plant weight at 187.5 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080859	Phytotoxicity against Arachis hypogaea (peanut) assessed as growth inhibition at 75 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103452	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 15 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080854	Phytotoxicity against Glycine max (soybean) assessed as growth inhibition at 150 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1103504	Herbicidal activity against fat hen Chenopodium album assessed as weed growth inhibition at 75 g/ha pre-emergence treatment measured after 24 hr	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1103482	Phytotoxicity against Oryza sativa (rice) assessed as growth inhibition at 15 g/ha pre-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080876	Post-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 15 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1091464	Herbicidal activity against Digitaria sanguinalis (hairy crabgrass) assessed as inhibition of fresh weed plant weight at 22.5 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1103447	Phytotoxicity against Brassica rapa subsp. oleifera assessed as growth inhibition at 30 g/ha post-emergence treatment measured after 15 days by crop-selectivity assay	2005	Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20	Synthesis and herbicidal activity of 2-(7-fluoro-3-oxo- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)isoindoline-1,3-diones.
AID1080901	Post-emergence herbicidal activity against Abutilon theophrasti (velvetleaf) assessed as growth inhibition at 75 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080857	Phytotoxicity against Arachis hypogaea (peanut) assessed as growth inhibition at 300 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1091469	Herbicidal activity against Amaranthus retroflexus assessed as inhibition of fresh weed plant weight at 22.5 g/ha using pre-emergence treatment protocol	2008	Journal of agricultural and food chemistry, Oct-22, Volume: 56, Issue:20	Novel protoporphyrinogen oxidase inhibitors: 3H-pyrazolo[3,4-d][1,2,3]triazin-4-one derivatives.
AID1080888	Post-emergence herbicidal activity against Chenopodium album assessed as growth inhibition at 7.5 g.a.i./ha applied at two-leaf stage measured after 15 days	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
AID1080850	Phytotoxicity against Gossypium (cotton) assessed as growth inhibition at 150 g.a.i/ha pre-emergent application measured after 15 days by greenhouse crop selectivity assay	2009	Journal of agricultural and food chemistry, Oct-28, Volume: 57, Issue:20	Synthesis and herbicidal activity of isoindoline-1,3-dione substituted benzoxazinone derivatives containing a carboxylic ester group.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (6.98)	18.2507
2000's	18 (41.86)	29.6817
2010's	12 (27.91)	24.3611
2020's	10 (23.26)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	44 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
protoporphyrin ix protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685. protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.	2.77	3
sucrose Saccharum: A plant genus of the family POACEAE widely cultivated in the tropics for the sweet cane that is processed into sugar.	2.01	1	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent
diquat Diquat: A contact herbicide used also to produce desiccation and defoliation. (From Merck Index, 11th ed). diquat : The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.	2.41	1	organic cation	defoliant; herbicide
adamantane Adamantane: A tricyclo bridged hydrocarbon.	2.17	1	adamantanes; polycyclic alkane
paraquat Paraquat: A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.. paraquat : An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.	2.41	1	organic cation	geroprotector; herbicide
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.41	1	copper group element atom; elemental gold
azides Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.	2.49	2	pseudohalide anion	mitochondrial respiratory-chain inhibitor
imazethapyr imazethapyr: do not confuse with imazapyr, which is the 5-desethyl analog of imazethapyr	2.76	2	aromatic carboxylic acid; pyridines
artemisinin (+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.	2.17	1	organic peroxide; sesquiterpene lactone	antimalarial; plant metabolite
artesunic acid [no description available]	2.17	1
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	2.42	2	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
s 23121 S 23121: structure given in first source. flumipropyn : A racemate comprising equimolar amounts of (R)- and (S)-flumipropynflumipropyn. A protoporphyrinogen oxidase inhibitor introduced by the Sumitomo Chemical Co., it was formerly used for the control of grasses and broad-leaved weeds in various crops.. 2-[5-(but-3-yn-2-yloxy)-4-chloro-2-fluorophenyl]-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione : A dicarboximide that is 4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione in which the nitrogen has been substituted by a 5-(but-3-yn-2-yloxy)-4-chloro-2-fluorophenyl group.	2.78	3	aromatic ether; dicarboximide; monochlorobenzenes; monofluorobenzenes; pyrroline; terminal acetylenic compound
D-fructopyranose [no description available]	2.01	1	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent
astaxanthine astaxanthine: a keto form of carotene; pigment in flesh of Scottish salmon (Salmo salar) crustacoa-lobster (Homarus gammarus, flamingo feathers; structure; a carotenoid without vitamin A activity, has shown anti-oxidant and anti-inflammatory activities. astaxanthin : A carotenone that consists of beta,beta-carotene-4,4'-dione bearing two hydroxy substituents at positions 3 and 3' (the 3S,3'S diastereomer). A carotenoid pigment found mainly in animals (crustaceans, echinoderms) but also occurring in plants. It can occur free (as a red pigment), as an ester, or as a blue, brown or green chromoprotein.	2.6	1	carotenol; carotenone	animal metabolite; anticoagulant; antioxidant; food colouring; plant metabolite
chlorophyll b [no description available]	2.03	1	chlorophyll	cofactor
chlorophyll a Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.	2.93	4	chlorophyll; methyl ester	cofactor
oz 439 artefenomel: an antimalarial ozonide; structure in first source	2.17	1
3-azido-7-hydroxycoumarin 3-azido-7-hydroxycoumarin: structure in first source	2.1	1
phosphinothricin phosphinothricin: RN given refers to parent cpd with unspecified isomeric designation; structure. phosphinothricin(1-) : Conjugate base of phosphinothricin arising from deprotonation of the phosphinate function.	2.41	1	organic anion
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	3.34	5
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.1	1	benzenes; hydroxycoumarin; methyl ketone
clay Clay: A naturally-occurring rock or soil constituent characterized by particles with a diameter of less than 0.005 mm. It is composed primarily of hydrous aluminum silicates, trace amounts of metal OXIDES, and organic matter.	2.02	1
pheophytin a pheophytin a: structure given in first source; RN given refers to (3S-(3alpha(2E,7S,11S),4beta,21beta))-isomer	2.03	1

Condition	Relationship Strength	Studies
Anemia A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.	2.61	2
Cardiac Toxicity [description not available]	2.6	1
Cardiotoxicity Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.	2.6	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	3.34	6
Teratogenesis The formation of CONGENITAL ABNORMALITIES.	2.49	2
Fetal Growth Restriction [description not available]	2.08	1
Fetal Growth Retardation Failure of a FETUS to attain expected GROWTH.	2.08	1
Blastocyst Disintegration [description not available]	2.1	1
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	2.01	1
Intraventricular Septal Defects [description not available]	1.99	1
Heart Septal Defects, Ventricular Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.	1.99	1

s 53482

Description

Cross-References

Synonyms (59)

Research Excerpts

Toxicity

Pharmacokinetics

Bioavailability

Dosage Studied

Roles (4)

Drug Classes (4)

Protein Targets (8)

Potency Measurements

Inhibition Measurements

Bioassays (162)

Research

Studies (43)

Market Indicators

Research Demand Index: 11.25

Study Types

s 53482

Description

Cross-References

Synonyms (59)

Research Excerpts

Toxicity

Pharmacokinetics

Bioavailability

Dosage Studied

Roles (4)

Drug Classes (4)

Protein Targets (8)

Potency Measurements

Inhibition Measurements

Bioassays (162)

Research

Studies (43)

Market Indicators

Research Demand Index: 11.25

Study Types

Related Drugs (23)

Related Conditions (11)