Compounds > thailanstatin a
Page last updated: 2024-11-13

thailanstatin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID71665768
CHEMBL ID2333561
CHEBI ID189280
SCHEMBL ID15675747
MeSH IDM0585970

Synonyms (13)

Synonym
CHEBI:189280
2-[(3r,4r,5r,7s)-5-[(1e,3e)-5-[(2s,3s,5r,6r)-5-[[(z,4s)-4-acetyloxypent-2-enoyl]amino]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dienyl]-4-hydroxy-1,6-dioxaspiro[2.5]octan-7-yl]acetic acid
thailanstatin a ,
CHEMBL2333561
SCHEMBL15675747
1426953-21-0
AKOS032946591
AT31108
MS-29897
EX-A5052
BP-28005
HY-129589
CS-0106808

Research Excerpts

Effects

ExcerptReferenceRelevance
"Thailanstatin A has been isolated recently from the fermentation broth of B. "( Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition.
Ghosh, AK; Jurica, MS; MacRae, AJ; Nie, S; Relitti, N; Veitschegger, AM, 2018)		2.21
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
C-glycosyl compoundA glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a carbon atom, thus creating a C-C bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID11775561-Octanol-buffer partition coefficient, log D of the compound at pH 7.4 by shake flask method2014Journal of natural products, Aug-22, Volume: 77, Issue:8
Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues.
AID736712Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID1177559Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues.
AID1895048Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth2021Journal of natural products, 05-28, Volume: 84, Issue:5
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
AID736711Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID736713Antiproliferative activity against human NCI-H232A cells assessed as growth inhibition measured after 48 hrs by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID1895044Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth2021Journal of natural products, 05-28, Volume: 84, Issue:5
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
AID1177560Cytotoxicity against human MDA-MB-DYT2 cells after 4 days by MTS/cell proliferation assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues.
AID736717Stability of the compound in phosphate buffer at pH 7.4 at 37 degC by HPLC2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID1177558Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues.
AID736715Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID1895049Cytotoxicity against HEK293T cells assessed as inhibition in cell growth2021Journal of natural products, 05-28, Volume: 84, Issue:5
Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors.
AID1177557Cytotoxicity against human NCI-H1975 cells after 4 days by MTS/cell proliferation assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues.
AID1177561Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay2014Journal of natural products, Aug-22, Volume: 77, Issue:8
Cytotoxic Spliceostatins from Burkholderia sp. and Their Semisynthetic Analogues.
AID736716Stability of the compound in phosphate buffer assessed as compound remaining after 8 to 78 hrs at pH 7.4 at 37 degC by HPLC2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
AID736714Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (83.33)24.3611
2020's2 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.31 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		2.1310aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
maleimide
[no description available]		2.1310dicarboximide;
maleimides		EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		2.1510pseudohalide anionmitochondrial respiratory-chain inhibitor
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		3.6620taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.1310cysteiniumfundamental metabolite
fr 901464
FR 901464: isolated from Pseudomonas; structure in first source		2.0810
fr 901464
[no description available]		3.6520acetate ester;
cyclic hemiketal;
monocarboxylic acid amide;
pyrans;
spiro-epoxide		antimicrobial agent;
antineoplastic agent;
bacterial metabolite
spliceostatin a
spliceostatin A: antiangiogenic agent that blocks expression of VEGF; structure in first source		3.4110
monomethyl auristatin e
[no description available]		3.4110
meayamycin
meayamycin: inhibits pre-mRNA splicing; has antineoplastic activity; structure in first source		3.4110
thailanstatin b
[no description available]		4.3250
ConditionIndicatedRelationship StrengthStudiesTrials
Androgen-Independent Prostatic Cancer
[description not available]		02.1510
Prostatic Neoplasms, Castration-Resistant
Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.		02.1510
Glaucoma
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)		02.0810
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.		02.1310