fr-901464 and herboxidiene

fr-901464 has been researched along with herboxidiene* in 1 studies

Reviews

1 review(s) available for fr-901464 and herboxidiene

Article	Year
Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1. Natural product reports, 2016, 05-04, Volume: 33, Issue:5 Covering: 1992 to 2015The natural products FR901464, pladienolide, and herboxidiene were discovered as activators of reporter gene systems. Unexpectedly, these compounds target neither transcription nor translation; rather, they target splicing factor 3B subunit 1 of the spliceosome, causing changes in splicing patterns. All of them showed anticancer activity in a low nanomolar range. Since their discovery, these molecules have been used in a variety of biological applications. Topics: Biological Products; Fatty Alcohols; Molecular Structure; Pyrans; RNA Splicing; RNA Splicing Factors; Spiro Compounds; Spliceosomes	2016

Article

Year

Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.

Natural product reports, 2016, 05-04, Volume: 33, Issue:5

Covering: 1992 to 2015The natural products FR901464, pladienolide, and herboxidiene were discovered as activators of reporter gene systems. Unexpectedly, these compounds target neither transcription nor translation; rather, they target splicing factor 3B subunit 1 of the spliceosome, causing changes in splicing patterns. All of them showed anticancer activity in a low nanomolar range. Since their discovery, these molecules have been used in a variety of biological applications.

Topics: Biological Products; Fatty Alcohols; Molecular Structure; Pyrans; RNA Splicing; RNA Splicing Factors; Spiro Compounds; Spliceosomes

2016