p-tert-butylphenolformaldehyde resin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

p-tert-butylphenolformaldehyde resin is a type of phenolic resin, synthesized through a condensation reaction between p-tert-butylphenol and formaldehyde. It is known for its high resistance to heat, chemicals, and solvents, making it valuable in various applications, such as adhesives, laminates, and molding compounds. Due to its excellent properties, p-tert-butylphenolformaldehyde resin is widely studied for its potential in enhancing the performance and durability of materials. The resin's synthesis and properties are subject to ongoing research to optimize its characteristics for specific applications.'

p-tert-butylphenolformaldehyde resin: irritant; used in glues; RN given refers to parent cpd; PTBP plastic is the macromolecular form of the resin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	104912
SCHEMBL ID	332381
MeSH ID	M0062691

Synonyms (10)

Synonym
ckm 1634
p-tert-butylphenol, formaldehyde resin
4-tert-butylphenol; formaldehyde
A844643
26808-99-1
25085-50-1
p-tert-butylphenolformaldehyde resin
68130-76-7
SCHEMBL332381
4-tert-butylphenol;formaldehyde

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" No meaningful differences were observed in the frequency or severity of adverse events; reports of burning and stinging following patch removal; or the frequency, intensity, or symptoms of persistent reactions when evaluated by age, sex, or race."	( Safety and efficacy evaluation of TRUE TEST panels 1.1, 2.1, and 3.1 in children and adolescents. Eichenfield, L; Hamann, C; Herro, EM; Jacob, SE; Matiz, C; Sullivan, K, )	0.13
"Patch testing is efficacious and safe in the pediatric population."	( Safety and efficacy evaluation of TRUE TEST panels 1.1, 2.1, and 3.1 in children and adolescents. Eichenfield, L; Hamann, C; Herro, EM; Jacob, SE; Matiz, C; Sullivan, K, )	0.13

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (58)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	18 (31.03)	18.7374
1990's	12 (20.69)	18.2507
2000's	16 (27.59)	29.6817
2010's	9 (15.52)	24.3611
2020's	3 (5.17)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.12

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	10.12 (24.57)
Research Supply Index	4.29 (2.92)
Research Growth Index	4.41 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (10.12)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (1.41%)	5.53%
Reviews	1 (1.41%)	6.00%
Case Studies	34 (47.89%)	4.05%
Observational	2 (2.82%)	0.25%
Other	33 (46.48%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	3.76	11	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	3.15	5	metal allergen; nickel group element atom	epitope; micronutrient
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	2.25	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
isoprene isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.	2.03	1	alkadiene; hemiterpene; volatile organic compound	plant metabolite
2-naphthylamine 2-Naphthylamine: A naphthalene derivative with carcinogenic action.. 2-naphthylamine : A naphthylamine carrying the amino group at position 2.	2.25	1	naphthylamine	carcinogenic agent
butylphen butylphen: irritant; structure. 4-tert-butylphenol : A member of the class of phenols that is phenol substituted with a tert-butyl group at position 4.	7.67	3	phenols	allergen
dibenzyl ether benzyl ether : A compound of formula PhCH2OR (R =/= H).. dibenzyl ether : A benzyl ether in which the oxygen atom is connected to two benzyl groups.	2	1	benzyl ether	metabolite
4-phenylenediamine 4-phenylenediamine: agent hair dye responsible for contact dermatitis; RN given refers to parent cpd. 1,4-phenylenediamine : A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.	2.52	2	phenylenediamine	allergen; dye; hapten; reagent
thiazoles [no description available]	1.96	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.25	1	copper group element atom; elemental gold
potassium dichromate Potassium Dichromate: Chromic acid (H2Cr2O7), dipotassium salt. A compound having bright orange-red crystals and used in dyeing, staining, tanning leather, as bleach, oxidizer, depolarizer for dry cells, etc. Medically it has been used externally as an astringent, antiseptic, and caustic. When taken internally, it is a corrosive poison.. potassium dichromate : A potassium salt that is the dipotassium salt of dichromic acid.	3.42	7	potassium salt	allergen; oxidising agent; sensitiser
nickel sulfate nickel sulfate: RN given refers to cpd with MF of Ni(2+)-H2SO4. nickel sulfate : A metal sulfate having nickel(2+) as the metal ion.	2.54	2	metal sulfate	allergen
chloroprene Chloroprene: Toxic, possibly carcinogenic, monomer of neoprene, a synthetic rubber; causes damage to skin, lungs, CNS, kidneys, liver, blood cells and fetuses. Synonym: 2-chlorobutadiene.	2.05	1	chloroolefin
butylated hydroxytoluene 2,6-di-tert-butyl-4-methylphenol : A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.	1.99	1	phenols	antioxidant; ferroptosis inhibitor; food additive; geroprotector
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	3.08	4	cobalt group element atom; metal allergen	micronutrient
captax captax: RN given refers to parent cpd. 1,3-benzothiazole-2-thiol : 1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.	1.96	1	aryl thiol; benzothiazoles	carcinogenic agent; metabolite
cobaltous chloride cobaltous chloride: RN given refers to unlabeled cpd; RN in Chemline for cobalt trichloride: 10241-04-0; RN for 60-labeled cpd: 14543-09-0; RN for 57-labeled cpd: 164113-89-1; RN for 58-labeled cpd: 29377-09-1; structure. cobalt dichloride : A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.	3.08	4	cobalt salt; inorganic chloride	allergen; calcium channel blocker; sensitiser; two-colour indicator
rosin rosin: Resin from plant. Do not confuse with the specific compound: 3-phenyl-2-propenyl-(E)-beta-D-glucopyranoside, also know as rosin.	2.4	2
nitrofurazone Nitrofurazone: A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and skin infections. Nitrofurazone has also been administered orally in the treatment of TRYPANOSOMIASIS.. nitrofurazone : A semicarbazone resulting from the formal condensation of semicarbazide with 5-nitrofuraldehyde. A broad spectrum antibacterial drug, although with little activity against Pseudomonas species, it is used as a local application for burns, ulcers, wounds and skin infections.	2.13	1
thimerosal Thimerosal: An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.. thimerosal : An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent.	2.59	2	alkylmercury compound	antifungal drug; antiseptic drug; disinfectant; drug allergen

Condition	Relationship Strength	Studies
Allergic Contact Dermatitis [description not available]	5.71	31
Dermatitis, Irritant A non-allergic contact dermatitis caused by prolonged exposure to irritants and not explained by delayed hypersensitivity mechanisms.	2.25	1
Eczema, Atopic [description not available]	2.68	3
Dermatitis, Occupational A recurrent contact dermatitis caused by substances found in the work place.	3.59	9
Palmoplantaris Pustulosis [description not available]	2.25	1
Eczema, Dyshidrotic A recurrent eczematous reaction characterized by the development of vesicular eruptions on the palms and soles, particularly along the sides and between the digits. It is accompanied by pruritus, a burning sensation, and hyperhidrosis. The disease is self-limiting, lasting only a few weeks. (Dorland, 27th ed)	2.25	1
Foot Dermatoses Skin diseases of the foot, general or unspecified.	3.5	8
Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	2.68	3
Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.	2.25	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	5.71	31
Dermatitis, Eczematous [description not available]	2.79	3
Eczema A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).	2.79	3
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	3.12	5
Dermatitis Medicamentosa [description not available]	2.13	1
Hypomelanosis [description not available]	2.06	1
Facial Dermatoses Skin diseases involving the FACE.	2.06	1
Hypopigmentation A condition caused by a deficiency or a loss of melanin pigmentation in the epidermis, also known as hypomelanosis. Hypopigmentation can be localized or generalized, and may result from genetic defects, trauma, inflammation, or infections.	2.06	1
Hand Dermatosis [description not available]	3.07	5
Hand Dermatoses Skin diseases involving the HANDS.	3.07	5
Cancer of Skin [description not available]	2.01	1
Cutaneous T-Cell Lymphoma [description not available]	2.01	1
Skin Neoplasms Tumors or cancer of the SKIN.	2.01	1
Lymphoma, T-Cell, Cutaneous A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.	2.01	1
Contact Dermatitis [description not available]	4.36	21
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	4.36	21
Atopic Hypersensitivity [description not available]	2.39	2
Leg Dermatoses A nonspecific term used to denote any cutaneous lesion or group of lesions, or eruptions of any type on the leg. (From Stedman, 25th ed)	1.96	1
Delayed Hypersensitivity [description not available]	2.37	2
Diseases, Occupational [description not available]	1.95	1
Airway Hyper-Responsiveness [description not available]	1.95	1
Absence of Voice [description not available]	1.95	1
Nail Diseases Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.	1.95	1
Chronic Illness [description not available]	1.98	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	1.98	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.98	1
Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	1.98	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.38	2
Allergic Reaction [description not available]	1.99	1
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	1.99	1
Allergy, Drug [description not available]	2	1
Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally.	2	1
Incontinentia Pigmenti Achromians [description not available]	2	1

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