Compounds > di-2-ethylhexyl sebacate
Page last updated: 2024-12-06

di-2-ethylhexyl sebacate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Di-2-ethylhexyl sebacate (DEHS) is a synthetic plasticizer, a type of chemical added to plastics to increase their flexibility and durability. It is a clear, colorless, and odorless liquid. DEHS is produced by the esterification reaction of sebacic acid with 2-ethylhexanol. DEHS is widely used in various applications, including PVC (polyvinyl chloride) products such as flooring, wall coverings, and vinyl toys. It is also used in adhesives, sealants, and cosmetics. DEHS is a non-volatile, non-flammable, and bio-compatible compound. It is generally considered safe for use in many applications, although concerns exist regarding its potential health effects. Research indicates that DEHS can be absorbed through the skin and inhaled, leading to potential adverse effects on the reproductive system, liver, and thyroid gland. Studies on DEHS focus on its potential environmental impact, its effects on human health, and alternative plasticizers that may be safer. The research aims to understand its fate in the environment, its persistence, and potential bioaccumulation in organisms. In addition, research explores potential health risks associated with DEHS exposure and investigates alternative plasticizers that are safer and less harmful to human health and the environment.'

Cross-References

ID SourceID
PubMed CID31218
CHEMBL ID3187356
SCHEMBL ID37169
MeSH IDM0113710

Synonyms (99)

Synonym
LS-15168
usaf ke-2
di-2-ethylhexyl isosebacate
isosebacic acid, di-2-ethylhexyl ester
dos ,
di(2-ethylhexyl) sebacate
reolube dos
monoplex dos
decanedioic acid, bis(2-ethylhexyl) ester
1-hexanol, sebacate
nsc68878
staflex dos
bisoflex dos
plexol
bis(2-ethylhexyl) decanedioate
bis(2-ethylhexyl) sebacate
edenol 888
sebacic acid bis(2-ethylhexyl) ester
wln: 4y2 & 1ov8vo1y4 & 2
2-ethylhexyl sebacate
bisoflex
sebacic acid, bis(2-ethylhexyl) ester
bis(ethylhexyl) sebacate
octoil s
nsc-68878
plexol 201j
122-62-3
px 438
bis-(2-ethylhexyl)ester kyseliny sebakove [czech]
uniflex dos
sebacic acid, di-2-ethylhexyl diester
bis(2-ethylhexyl)sebacate ,
edenor dehs
ai3-09124
reomol dds
einecs 204-558-8
brn 1806504
dioctyl sebacate (van)
1-hexanol, 2-ethyl-, sebacate
ccris 6191
ergoplast sdo
hsdb 2898
di-2-ethylhexyl sebacate
sebacic acid, bis(2-ethylhexyl)ester
nsc 68878
bis(2-ethylhexyl)decanedioate
sansocizer dos
bis(2-ethylhexyl) sebacate, technical grade, 90%
di(2-ethylhexyl)sebacate
bis(2-ethylhexyl) sebacate, >=97.0% (gc)
S0025
diethylhexyl sebacate
unii-u9ls47q72q
decanedioic acid, 1,10-bis(2-ethylhexyl) ester
4-02-00-02083 (beilstein handbook reference)
u9ls47q72q ,
bis-(2-ethylhexyl)ester kyseliny sebakove
ec 204-558-8
dtxsid7025055 ,
NCGC00257416-01
cas-122-62-3
tox21_303439
dtxcid005055
c26h50o4
29590-28-1
sebacic acid di(2-ethylhexyl) ester
FT-0631704
AKOS015903925
diethylhexyl sebacate [inci]
hallstar dos
aec diethylhexyl sebacate
diethylhexyl sebacate, (+/-)-
dub dos
hatcol 5110
bis(2-ethylhexyl) sebacate [hsdb]
(+/-)-diethylhexyl sebacate
bis(2-ethylhexyl) sebacate [mi]
SCHEMBL37169
CHEMBL3187356
plexol 201
bis(2-ethylhexyl) ester, decanedionic acid
behs
ergoplast sno
plasthall dos
decanedioic acid, di-(2-ethylhexyl) ester
bis(2-ethylhexyl) ester, sebacic acid
J-004836
bis(2-ethylhexyl) sebacate, selectophore(tm), >=97.0%
mfcd00009497
decanedioic acid bis(2-ethylhexyl) ester
decanedioic acid, 1,10-bis (2-ethylhexyl) ester
Q4387284
sebacic acid bis (2_ethylhexyl) ester
decanedioic acid bis(2_ethylhexyl) ester
bis(2_ethylhexyl)sebacate
AT25397
CS-0152375
1,10-bis(2-ethylhexyl) decanedioate
dioctyl sebacate 99%

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Reactivity to MCH was expressed as the dose-response slope; it was calculated as percent final change in FEV1/cumulative dose MCH inhaled."( Intersubject variability in particle deposition does not explain variability in responsiveness to methacholine.
Anderson, PJ; Blanchard, JD; Brain, JD; Feldman, HA; Garshick, E, 1991)		0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency6.85900.006038.004119,952.5996AID1159521
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency27.30600.001530.607315,848.9004AID1224841; AID1259401
estrogen nuclear receptor alphaHomo sapiens (human)Potency3.06380.000229.305416,493.5996AID743079
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (12.12)18.7374
1990's8 (24.24)18.2507
2000's7 (21.21)29.6817
2010's11 (33.33)24.3611
2020's3 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.03 (24.57)
Research Supply Index3.61 (2.92)
Research Growth Index4.79 (4.65)
Search Engine Demand Index30.30 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (2.86%)5.53%
Reviews2 (5.71%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other32 (91.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phthalic acid
phthalic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7178. phthalic acid : A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.		2.610benzenedicarboxylic acidhuman xenobiotic metabolite
sulfur dioxide
Sulfur Dioxide: A highly toxic, colorless, nonflammable gas. It is used as a pharmaceutical aid and antioxidant. It is also an environmental air pollutant.		2.1310sulfur oxideEscherichia coli metabolite;
food bleaching agent;
refrigerant
toluene
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.		2.0510methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
undecylenic acid
undecylenic acid: a fatty acid with a terminal double bond. 10-undecenoic acid : An undecenoic acid having its double bond in the 10-position. It is derived from castor oil and is used for the treatment of skin problems.. undecenoic acid : A C11, straight-chain fatty acid carrying a C=C double bond at any position.		2.110undecenoic acidantifungal drug;
plant metabolite
methacholine chloride
Methacholine Chloride: A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)		3.5930quaternary ammonium salt
ethyl sebacate
ethyl sebacate: causes contact dermatitis		2.2110fatty acid ester
diethylhexyl phthalate
Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.		1.9710diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser
n-hexadecane
n-hexadecane: structure. hexadecane : A straight-chain alkane with 16 carbon atoms. It is a component of essential oil isolated from long pepper.		2.0510long-chain alkanenon-polar solvent;
plant metabolite;
volatile oil component
n-tetradecane
tetradecane : A straight chain alkane consisting of 14 carbon atoms.		2.0510long-chain alkaneplant metabolite;
volatile oil component
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.0310copper group element atom;
elemental silver		Escherichia coli metabolite
rubrene
[no description available]		2.0310
delphinidin
Paraffin: A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.. delphinidin chloride : An anthocyanidin chloride that has delphinidin as the cationic counterpart.		2.0710anthocyanidin chloride
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.		2.520oxygen hydride;
oxygen radical;
reactive oxygen species
2-nitrophenyl octyl ether
[no description available]		2.4920
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		2.2110octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
squalene
Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate		2.0710triterpenehuman metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
valinomycin
Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.. valinomycin : A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.		2.2510cyclodepsipeptide;
macrocycle		antimicrobial agent;
antiviral agent;
bacterial metabolite;
potassium ionophore
calcitriol
dihydroxy-vitamin D3: as a major in vitro metabolite of 1alpha,25-dihydroxyvitamin D3, produced in primary cultures of neonatal human keratinocytes		2.2110D3 vitamins;
hydroxycalciol;
triol		antineoplastic agent;
antipsoriatic;
bone density conservation agent;
calcium channel agonist;
calcium channel modulator;
hormone;
human metabolite;
immunomodulator;
metabolite;
mouse metabolite;
nutraceutical
lead
Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.		2.0310carbon group element atom;
elemental lead;
metal atom		neurotoxin
cellulose
DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.		2.0310glycoside
acetylcellulose
acetylcellulose: coating compound. cellulose acetate : A glucan derivative obtained through the esterification of cellulose by acetic anhydride or acetic acid, resulting in the substitution of some of the hydroxy groups of cellulose by acetyl groups. It is used in a variety of applications including base material for photographic film, clothing, membrane filters, coatings, food packaging, and as a frame material for eyeglasses.		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Ozena
[description not available]		02.0510
Rhinitis, Atrophic
A chronic inflammation in which the NASAL MUCOSA gradually changes from a functional to a non-functional lining without mucociliary clearance. It is often accompanied by degradation of the bony TURBINATES, and the foul-smelling mucus which forms a greenish crust (ozena).		02.0510
Electrolytes
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)		02.0310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		03.8440
Centriacinar Emphysema
[description not available]		02.0310
Asthma, Bronchial
[description not available]		01.9810
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		01.9810
Obstructive Lung Diseases
[description not available]		04.0630
Lung Diseases, Obstructive
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.		04.0630
Bronchial Hyperreactivity
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.		0210
Disease, Pulmonary
[description not available]		01.9710
Lung Diseases
Pathological processes involving any part of the LUNG.		01.9710
Experimental Hepatoma
[description not available]		01.9710
Condition, Preneoplastic
[description not available]		01.9710
Precancerous Conditions
Pathological conditions that tend eventually to become malignant.		01.9710