davallialactone and hispidin

davallialactone has been researched along with hispidin* in 2 studies

Other Studies

2 other study(ies) available for davallialactone and hispidin

Article	Year
Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice. Journal of natural products, 2012, Oct-26, Volume: 75, Issue:10 In this study the protective effects of davallialactone (1), isolated from Inonotus xeranticus, have been examined against carbon tetrachloride (CCl₄-induced acute liver injury. Mice received subcutaneous injection of 1 (2.5, 5, and 10 mg/kg) for three days before CCl₄ injection (1 mg/kg). Protection from liver injury by 1 was confirmed by the observation of decreased serum transaminases and diminished necrosis of liver tissue. Reduced hepatic injury was very similar to that observed with silymarin, a known hepatoprotective drug used in this work for comparison. The groups treated with 1 had reduced reactive oxygen species (ROS), reduced serum malonyldialdehyde levels, and increased levels of liver Cu/Zn superoxide dismutase, as compared to the CCl₄ control group. The expression of heme oxygenase-1 in the liver tissue was increased and the activity of liver cytochrome P4502E1 was restored in the mice treated with 1. In addition, levels of serum tumor necrosis factor-alpha (TNF-α), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2), numbers of macrophage, and cleaved caspase-3-positive hepatocytes were reduced in the groups treated with 1. These findings suggest that davallialactone has protective effects against CCl₄-induced acute liver injury, and this protection is likely due to the suppression of ROS-induced lipid peroxidation and inflammatory response. Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Hepatocytes; Lactones; Liver; Male; Mice; Molecular Structure; Oxidative Stress; Pyrones; Tumor Necrosis Factor-alpha	2012
Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity. Bioorganic & medicinal chemistry letters, 2006, May-01, Volume: 16, Issue:9 Three new free radical scavengers were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compound davallialactone. Their structures were established as hispidin analogs by extensive NMR spectral data. Compounds 3 and 4 displayed significant scavenging activity against the superoxide radical anion, ABTS radical cation, and DPPH radical, while 1 and 2 exhibited potent antioxidative activity only against ABTS radical cation. Topics: Agaricales; Anions; Antioxidants; Benzothiazoles; Biphenyl Compounds; Cations; Free Radical Scavengers; Free Radicals; Magnetic Resonance Spectroscopy; Molecular Structure; Picrates; Pyrones; Reference Standards; Stereoisomerism; Sulfonic Acids; Superoxides	2006

Article

Year

Hispidin analogue davallialactone attenuates carbon tetrachloride-induced hepatotoxicity in mice.

Journal of natural products, 2012, Oct-26, Volume: 75, Issue:10

In this study the protective effects of davallialactone (1), isolated from Inonotus xeranticus, have been examined against carbon tetrachloride (CCl₄-induced acute liver injury. Mice received subcutaneous injection of 1 (2.5, 5, and 10 mg/kg) for three days before CCl₄ injection (1 mg/kg). Protection from liver injury by 1 was confirmed by the observation of decreased serum transaminases and diminished necrosis of liver tissue. Reduced hepatic injury was very similar to that observed with silymarin, a known hepatoprotective drug used in this work for comparison. The groups treated with 1 had reduced reactive oxygen species (ROS), reduced serum malonyldialdehyde levels, and increased levels of liver Cu/Zn superoxide dismutase, as compared to the CCl₄ control group. The expression of heme oxygenase-1 in the liver tissue was increased and the activity of liver cytochrome P4502E1 was restored in the mice treated with 1. In addition, levels of serum tumor necrosis factor-alpha (TNF-α), inducible NO synthase (iNOS), and cyclooxygenase-2 (COX-2), numbers of macrophage, and cleaved caspase-3-positive hepatocytes were reduced in the groups treated with 1. These findings suggest that davallialactone has protective effects against CCl₄-induced acute liver injury, and this protection is likely due to the suppression of ROS-induced lipid peroxidation and inflammatory response.

Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Hepatocytes; Lactones; Liver; Male; Mice; Molecular Structure; Oxidative Stress; Pyrones; Tumor Necrosis Factor-alpha

2012

Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity.

Bioorganic & medicinal chemistry letters, 2006, May-01, Volume: 16, Issue:9

Three new free radical scavengers were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compound davallialactone. Their structures were established as hispidin analogs by extensive NMR spectral data. Compounds 3 and 4 displayed significant scavenging activity against the superoxide radical anion, ABTS radical cation, and DPPH radical, while 1 and 2 exhibited potent antioxidative activity only against ABTS radical cation.

Topics: Agaricales; Anions; Antioxidants; Benzothiazoles; Biphenyl Compounds; Cations; Free Radical Scavengers; Free Radicals; Magnetic Resonance Spectroscopy; Molecular Structure; Picrates; Pyrones; Reference Standards; Stereoisomerism; Sulfonic Acids; Superoxides

2006