Page last updated: 2024-12-08
cleistopholine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
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Protein Interactions
Research Growth
Description
cleistopholine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 457732 |
CHEMBL ID | 444067 |
SCHEMBL ID | 6358965 |
MeSH ID | M0499318 |
Synonyms (8)
Synonym |
---|
cleistopholine |
CHEMBL444067 |
96889-94-0 |
4-methylbenzo(g)quinoline-5,10-dione |
c14h9no2 |
SCHEMBL6358965 |
GVRYUHXXENMGEV-UHFFFAOYSA-N |
DTXSID30242618 |
Research Excerpts
Overview
Cleistopholine is a natural alkaloid present in plants with numerous biological activities.
Excerpt | Reference | Relevance |
---|---|---|
"Cleistopholine is a natural alkaloid present in plants with numerous biological activities. " | ( Cleistopholine isolated from Enicosanthellum pulchrum exhibits apoptogenic properties in human ovarian cancer cells. Ali, HM; Dehghan, F; Hashim, NM; Karimian, H; Majid, NA; Mohan, S; Nordin, N; Rahman, MA, 2016) | 3.32 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (30)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID360353 | Cytotoxicity against human HepG2(2.2.15) cells by MTT assay | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Cytotoxic constituents of the fruits of Cananga odorata. |
AID1668165 | Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-D-glucoside as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by colorimetric assay | 2020 | Bioorganic & medicinal chemistry, 05-15, Volume: 28, Issue:10 | α-Glucosidase inhibitory and nitric oxide production inhibitory activities of alkaloids isolated from a twig extract of Polyalthia cinnamomea. |
AID39700 | In vitro antifungal activity against Aspergillus fumigatus ATCC 26934. | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines. |
AID245052 | Minimum inhibitory concentration against Schizosaccharomyces pombe | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID336957 | Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio | |||
AID336956 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 10 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA | |||
AID244927 | Minimum inhibitory concentration against Escherichia coli | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID244893 | Minimum inhibitory concentration against Mucor mucedo | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID45479 | In vitro antifungal activity against Candida albicans B311. | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines. |
AID360352 | Cytotoxicity against human HepG2 cells by MTT assay | 2001 | Journal of natural products, May, Volume: 64, Issue:5 | Cytotoxic constituents of the fruits of Cananga odorata. |
AID336959 | Cytotoxicity against human Raji cells assessed as cell viability at 100 molar ratio | |||
AID244976 | Minimum inhibitory concentration against Rhizopus chinensis | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID244917 | Minimum inhibitory concentration against Candida utilis | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID244928 | Minimum inhibitory concentration against Proteus vulgaris | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID245030 | Minimum inhibitory concentration against Penicillium chrysogenum | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID55038 | In vitro anti-mycobacterial activity against Cryptococcus neoformans ATCC 32264. | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines. |
AID336960 | Cytotoxicity against human Raji cells assessed as cell viability at 10 molar ratio | |||
AID336953 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 1000 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA | |||
AID336954 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 500 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA | |||
AID336958 | Cytotoxicity against human Raji cells assessed as cell viability at 500 molar ratio | |||
AID774608 | Antimicrobial activity against Mycobacterium intracellulare | 2013 | European journal of medicinal chemistry, Sep, Volume: 67 | Synthesis and antimycobacterial activity of analogues of the bioactive natural products sampangine and cleistopholine. |
AID245019 | Minimum inhibitory concentration against Pseudomonas aeruginosa | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID245041 | Minimum inhibitory concentration against Saccharomyces cerevisiae | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID244960 | Minimum inhibitory concentration against Rhodotorula rubra | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID336955 | Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 100 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA | |||
AID144140 | In vitro anti-mycobacterial activity against Mycobacterium intracellular ATCC 23068. | 1992 | Journal of medicinal chemistry, Oct-30, Volume: 35, Issue:22 | Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/antimycobacterial activity of A- and B-ring-functionalized sampangines. |
AID244959 | Minimum inhibitory concentration against Bacillus subtilis | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID244958 | Minimum inhibitory concentration against Aspergillus niger | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID245006 | Minimum inhibitory concentration against Staphylococcus aureus | 2005 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4 | Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds. |
AID1872633 | Antibacterial activity against Mycobacterium tuberculosis incubated for 5 days by Alamar blue staining method | 2022 | European journal of medicinal chemistry, Mar-15, Volume: 232 | Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (10)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (10.00) | 18.2507 |
2000's | 4 (40.00) | 29.6817 |
2010's | 3 (30.00) | 24.3611 |
2020's | 2 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 11 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |