benzo(g)isoquinoline-5,10-dione profile

benzo(g)isoquinoline-5,10-dione: insect teratogen [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	100650
CHEMBL ID	179617
SCHEMBL ID	421291
MeSH ID	M0117961

Synonym
nsc338695
nsc-338695
46492-08-4
benz[g]isoquinoline-5,10-dione, 99%
biquidone
FT-0639858
benzo[g]isoquinoline-5,10-dione
CHEMBL179617 ,
benz[g]isoquinoline-5,10-dione
benzo(g)isoquinoline-5,10-dione
benz(g)isoquinoline-5,10-dione
nsc 338695
bgid
AKOS015889524
SCHEMBL421291
2-azaanthraquinone
DTXSID80196854
5h,10h-benzo[g]isoquinoline-5,10-dione
AS-60180
5,10-dihydrobenzo[g]isoquinoline-5,10-dione
benz(g)isoquinoline-5,10-dione,99%
F53513
CS-0361193
WBA49208
bdbm50599583

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50 (µMol)	20.2000	0.0000	2.3789	9.7700	AID1888748
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50 (µMol)	4.2800	0.0000	1.8914	9.5700	AID1888749
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
biogenic amine metabolic process	Amine oxidase [flavin-containing] A	Homo sapiens (human)
positive regulation of signal transduction	Amine oxidase [flavin-containing] A	Homo sapiens (human)
dopamine catabolic process	Amine oxidase [flavin-containing] A	Homo sapiens (human)
response to xenobiotic stimulus	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to toxic substance	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to aluminum ion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to selenium ion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
negative regulation of serotonin secretion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
phenylethylamine catabolic process	Amine oxidase [flavin-containing] B	Homo sapiens (human)
substantia nigra development	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to lipopolysaccharide	Amine oxidase [flavin-containing] B	Homo sapiens (human)
dopamine catabolic process	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to ethanol	Amine oxidase [flavin-containing] B	Homo sapiens (human)
positive regulation of dopamine metabolic process	Amine oxidase [flavin-containing] B	Homo sapiens (human)
hydrogen peroxide biosynthetic process	Amine oxidase [flavin-containing] B	Homo sapiens (human)
response to corticosterone	Amine oxidase [flavin-containing] B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
protein binding	Amine oxidase [flavin-containing] A	Homo sapiens (human)
primary amine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
aliphatic amine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
monoamine oxidase activity	Amine oxidase [flavin-containing] A	Homo sapiens (human)
flavin adenine dinucleotide binding	Amine oxidase [flavin-containing] A	Homo sapiens (human)
protein binding	Amine oxidase [flavin-containing] B	Homo sapiens (human)
primary amine oxidase activity	Amine oxidase [flavin-containing] B	Homo sapiens (human)
electron transfer activity	Amine oxidase [flavin-containing] B	Homo sapiens (human)
identical protein binding	Amine oxidase [flavin-containing] B	Homo sapiens (human)
aliphatic amine oxidase activity	Amine oxidase [flavin-containing] B	Homo sapiens (human)
monoamine oxidase activity	Amine oxidase [flavin-containing] B	Homo sapiens (human)
flavin adenine dinucleotide binding	Amine oxidase [flavin-containing] B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
mitochondrion	Amine oxidase [flavin-containing] A	Homo sapiens (human)
mitochondrial outer membrane	Amine oxidase [flavin-containing] A	Homo sapiens (human)
cytosol	Amine oxidase [flavin-containing] A	Homo sapiens (human)
mitochondrion	Amine oxidase [flavin-containing] A	Homo sapiens (human)
mitochondrion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
mitochondrial envelope	Amine oxidase [flavin-containing] B	Homo sapiens (human)
mitochondrial outer membrane	Amine oxidase [flavin-containing] B	Homo sapiens (human)
dendrite	Amine oxidase [flavin-containing] B	Homo sapiens (human)
neuronal cell body	Amine oxidase [flavin-containing] B	Homo sapiens (human)
mitochondrion	Amine oxidase [flavin-containing] B	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (31)

Assay ID	Title	Year	Journal	Article
AID244928	Minimum inhibitory concentration against Proteus vulgaris	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID244976	Minimum inhibitory concentration against Rhizopus chinensis	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID244958	Minimum inhibitory concentration against Aspergillus niger	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID336960	Cytotoxicity against human Raji cells assessed as cell viability at 10 molar ratio
AID1867247	Antibacterial activity against multidrug resistant Helicobacter pylori HP159 assessed as bacterial growth inhibition incubated for 3 days by broth microdilution method
AID244927	Minimum inhibitory concentration against Escherichia coli	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID244960	Minimum inhibitory concentration against Rhodotorula rubra	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID1867250	Antibiofilm activity against Helicobacter pylori G27 assessed as reduction in preformed bacterial biofilm at 4 times MIC by crystal violet staining based assay
AID245019	Minimum inhibitory concentration against Pseudomonas aeruginosa	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID244959	Minimum inhibitory concentration against Bacillus subtilis	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID336955	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 100 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA
AID244893	Minimum inhibitory concentration against Mucor mucedo	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID1888749	Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by fluorescence spectrophotometric assay	2022	Bioorganic & medicinal chemistry, 01-15, Volume: 54	Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.
AID1867251	Antibiofilm activity against Helicobacter pylori G27 assessed as reduction in viable bacteria within biofilms at 0.25 ug/ml incubated for 20 hrs by alamar blue assay
AID245041	Minimum inhibitory concentration against Saccharomyces cerevisiae	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID245052	Minimum inhibitory concentration against Schizosaccharomyces pombe	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID336956	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 10 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA
AID1867248	Antibacterial activity against multidrug resistant Helicobacter pylori JRES00015 assessed as bacterial growth inhibition incubated for 3 days by broth microdilution method
AID336953	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 1000 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA
AID336954	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 500 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA
AID245006	Minimum inhibitory concentration against Staphylococcus aureus	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID1867249	Potency index, ratio of metronidazole MIC to test compound MIC for antibacterial activity against multidrug resistant Helicobacter pylori JRES00015
AID1867246	Antibacterial activity against multidrug resistant Helicobacter pylori G27 assessed as bacterial growth inhibition incubated for 3 days by broth microdilution method
AID245030	Minimum inhibitory concentration against Penicillium chrysogenum	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID244917	Minimum inhibitory concentration against Candida utilis	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds.
AID336958	Cytotoxicity against human Raji cells assessed as cell viability at 500 molar ratio
AID1867252	Antibiofilm activity against Helicobacter pylori G27 assessed as reduction in viable cells count at 4 times MIC
AID1888748	Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by fluorescence spectrophotometric assay	2022	Bioorganic & medicinal chemistry, 01-15, Volume: 54	Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.
AID336959	Cytotoxicity against human Raji cells assessed as cell viability at 100 molar ratio
AID336957	Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio
AID1888750	Selectivity index, ratio IC50 for recombinant human MAO-B to IC50 for recombinant human MAO-A	2022	Bioorganic & medicinal chemistry, 01-15, Volume: 54	Phenothiazine, anthraquinone and related tricyclic derivatives as inhibitors of monoamine oxidase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (14.29)	18.7374
1990's	1 (14.29)	18.2507
2000's	2 (28.57)	29.6817
2010's	1 (14.29)	24.3611
2020's	2 (28.57)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
danthron danthron: structure. chrysazin : A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 8.	2.41	1	dihydroxyanthraquinone	apoptosis inducer; plant metabolite
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	2.41	1	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
1,2,5,8-tetrahydroxy anthraquinone 1,2,5,8-tetrahydroxy anthraquinone: structure in first source. quinalizarin : A tetrahydroxyanthraquinone having the four hydroxy groups at the 1-, 2-, 5- and 8-positions.	2.41	1	tetrahydroxyanthraquinone	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
carbostyril Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.. quinolin-2(1H)-one : A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.	1.96	1	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite
purpurin purpurin: from Rubiaceae plants; structure in first source. purpurin : A trihydroxyanthraquinone derived from anthracene by substitution with oxo groups at C-9 and C-10 and with hydroxy groups at C-1, C-2 and C-4.	2.41	1	trihydroxyanthraquinone	biological pigment; histological dye; plant metabolite
1,4-dihydroxyanthraquinone 1,4-dihydroxyanthraquinone: structure given in first source. quinizarin : A dihydroxyanthraquinone having the two hydroxy substituents at the 1- and 4-positions; formally derived from anthraquinone by replacement of two hydrogen atoms by hydroxy groups	2.41	1	dihydroxyanthraquinone	dye
9,10-phenanthrenequinone 9,10-phenanthrenequinone: structure	2.41	1	phenanthrenes
2,6-dihydroxyanthraquinone 2,6-dihydroxyanthraquinone: structure given in first source. anthraflavic acid : A dihydroxyanthraquinone that is anthracene substituted by hydroxy groups at C-3 and C-7 and oxo groups at C-9 and C-10.	2.41	1	dihydroxyanthraquinone	antimutagen; plant metabolite
9,10-anthraquinone 9,10-anthraquinone : An anthraquinone that is anthracene in which positions 9 and 10 have been oxidised to carbonyls.	2.41	1	anthraquinone
anthrone anthrone: used in colorimetric determination of sugar & animal starch in body fluids; structure. anthrone : A member of the class of anthracenes that is 9,10-dihydroanthracene carrying an oxo group at C-9.	2.41	1	anthracenone	radical scavenger
aminacrine Aminacrine: A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.. 9-aminoacridine : An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections.	2.41	1	aminoacridines; primary amino compound	acid-base indicator; antiinfective agent; antiseptic drug; fluorescent dye; MALDI matrix material; mutagen
xanthone xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.	2.41	1	xanthones	insecticide
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	2.41	1	xanthene
anthrarufin 1,5-dihydroxyanthraquinone: used in ferric ion sensing as an inclusion complex with beta-cyclodextrin; structure in first source. anthrarufin : A dihydroxyanthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 1 and 5.	2.41	1	dihydroxyanthraquinone
2,6-diaminoanthraquinone 2,6-diaminoanthraquinone: structure in first source	2.41	1
aloe emodin aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.	2.41	1	aromatic primary alcohol; dihydroxyanthraquinone	antineoplastic agent; plant metabolite
7,9-dimethylbenz(c)acridine [no description available]	2.41	1
1,2-diaminoanthraquinone [no description available]	2.41	1
1,4-diaminoanthraquinone [no description available]	2.41	1
9-chloroacridine 9-chloroacridine: chromogenic reagent for detection of arylhydroxylamines & arylamines on paper & thin layer chromatograms; structure	2.41	1
n-methylphenothiazine N-methylphenothiazine: structure given in first source	2.41	1	phenothiazines
onychine onychine: from Cleistopholis patens; structure given in first source; RN from Chem Abst. Index Guide 1986	2.02	1
xanthydrol [no description available]	2.41	1
cinnabarinic acid cinnabarinic acid: structure	2.41	1	phenoxazine
cleistopholine cleistopholine: structure in first source	2.02	1

benzo(g)isoquinoline-5,10-dione

Description

Cross-References

Synonyms (25)

Protein Targets (2)

Inhibition Measurements

Biological Processes (15)

Molecular Functions (7)

Ceullar Components (6)

Bioassays (31)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.63

Study Types

benzo(g)isoquinoline-5,10-dione

Description

Cross-References

Synonyms (25)

Protein Targets (2)

Inhibition Measurements

Biological Processes (15)

Molecular Functions (7)

Ceullar Components (6)

Bioassays (31)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.63

Study Types

Related Drugs (25)

Related Conditions (0)