Page last updated: 2024-11-13

J147

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

J147: neurotrophic curcumin derivative compound that has enhanced stability and bioavailability over curcumin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25229652
CHEMBL ID2387144
CHEBI ID192601
SCHEMBL ID12995834
SCHEMBL ID21294999

Synonyms (37)

Synonym
n-(2,4-dimethylphenyl)-2,2,2-triluoro-n-[(e)-(3-methoxyphenyl)methylideneamino]acetamide
1807913-16-1
CHEBI:192601
j147
j-147
CHEMBL2387144
S5269
CS-3688
SCHEMBL12995834
1146963-51-0
2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
AC-35232
HY-13779
AKOS024458485
n-(2,4-dimethylphenyl)-2,2,2-trifluoro-n'-[(3-methoxyphenyl)methylidene]acetohydrazide
mfcd25976644
n-(2,4-dimethylphenyl)-2,2,2-trifluoro-n'-[(1e)-(3-methoxyphenyl)methylidene]acetohydrazide
n-(2,4-dimethylphenyl)-2,2,2-trifluoro-n'-(3-methoxybenzylidene)acetohydrazide
EX-A2235
n-(2,4-dimethylphenyl)-2,2,2-trifluoro-n'-[(e)-(3-methoxyphenyl)methylene]acetohydrazide
DB13957
AS-16718
SCHEMBL21294999
n-(2,4-dimethylphenyl)-2,2,2-trifluoro-n-[(e)-(3-methoxyphenyl)methylideneamino]acetamide
acetic acid, 2,2,2-trifluoro-, (2e)-1-(2,4-dimethylphenyl)-2-((3-methoxyphenyl)methylene)hydrazide
unii-z41h3c5bt9
acetic acid, 2,2,2-trifluoro-, 1-(2,4-dimethylphenyl)-2-((3-methoxyphenyl)methylene)hydrazide
Z41H3C5BT9 ,
n-(2,4-dimethylphenyl)-2,2,2-trifluoro-n-((e)-(3-methoxyphenyl)methylideneamino)acetamide
acetic acid, 2,2,2-trifluoro-, 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
HMS3886O17
CCG-268030
(e)-n-(2,4-dimethylphenyl)-2,2,2-trifluoro-n'-(3-methoxybenzylidene)acetohydrazide
A894156
hymzaygfknnhdn-ssdvnmtosa-n
DTXSID501045787
n-(2,4-dimethylphenyl)-2,2,2-trifluoro-n'-[(e)-(3-methoxyphenyl)methylidene]acetohydrazide

Research Excerpts

Overview

J147 is a novel drug candidate developed to treat neurological dysfunction.

ExcerptReferenceRelevance
"J147 is a novel drug candidate developed to treat neurological dysfunction. "( The Alzheimer's disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver.
Currais, A; Fischer, W; Huang, L; Kepchia, D; Liang, Z; Maher, P, 2022
)
2.43

Treatment

ExcerptReferenceRelevance
"J147 pretreatment markedly downregulated expression of IL-6, IL-1β, and TNF-α, and the mean fluorescence intensity of ionized calcium-binding adapter protein-1 in microglia."( J147 ameliorates sepsis-induced depressive-like behaviors in mice by attenuating neuroinflammation through regulating the TLR4/NF-κB signaling pathway.
Ke, C; Liu, Y; Pan, H; Qiu, F; Zeng, C, 2023
)
3.07
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
anilideAny aromatic amide obtained by acylation of aniline.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID748848Drug metabolism in mouse liver microsomes assessed as (E)-2,2,2-trifluoro-N-(4-(hydroxymethyl)-2-methylphenyl)-N'-(3-methoxybenzylidene)acetohydrazide retention time at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748865Drug metabolism in human liver microsomes assessed as formation of (E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-(3-hydroxybenzyli-dene)acetohydrazide at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748853Half life in human liver microsomes at 5 uM by LC/MS/MS analysis in presence of NADPH2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748876Drug metabolism in mouse liver microsomes assessed as metabolite M5 retention time at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748864Drug metabolism in human liver microsomes assessed as formation of (E)-2,2,2-trifluoro-N-(4-(hydroxymethyl)-2-methylphenyl)-N'-(3-methoxybenzylidene)acetohydrazide at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748872Drug metabolism in human liver microsomes assessed as formation of 3-methoxy benzaldehyde at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748851Drug metabolism in human liver microsomes assessed as retention time at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748862Half life in BALB/c mouse blood at 20 mg/kg, iv administered in corn oil by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748863Half life in BALB/c mouse brain at 20 mg/kg, iv administered in corn oil by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748861Drug metabolism in BALB/c mouse blood assessed as retention time at 20 mg/kg, iv administered in corn oil by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748857Neuroprotective activity in rat primary cortical neurons assessed as reduction in trophic factor withdrawal after 2 days by fluorescent live-dead assay2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748873Drug metabolism in human liver microsomes assessed as formation of 2,4-dimethylhydrazine at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748849Drug metabolism in mouse liver microsomes assessed as (E)-N'-(3,4-dihydroxybenzylidene)-N-(2,4-dimethylphenyl)-2,2,2-trifluoroacetohydrazide retention time at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748854Half life in mouse liver microsomes at 5 uM by LC/MS/MS analysis in presence of NADPH2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748874Drug metabolism in human liver microsomes assessed as formation of 2,4-dimethylaniline at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748858Drug metabolism in BALB/c mouse blood assessed as (E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-(3-hydroxybenzyli-dene)acetohydrazide retention time at 20 mg/kg, iv administered in corn oil by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748852Drug metabolism in mouse liver microsomes assessed as retention time at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748869Drug metabolism in mouse liver microsomes assessed as formation of 3-methoxy benzaldehyde at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748866Drug metabolism in mouse plasma assessed as formation of 2,4-dimethylhydrazine at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748860Drug metabolism in BALB/c mouse blood assessed as metabolite BM1 retention time at 20 mg/kg, iv administered in corn oil by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748868Drug metabolism in mouse plasma assessed as formation of 2,4-dimethylaniline at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748856Neuroprotective activity in human MC65 cells expressing C-terminal 99 amino acids from beta secretase assessed as reduction in intracellular amyloid beta toxicity after 4 days by MTT assay2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748859Drug metabolism in BALB/c mouse blood assessed as metabolite BM2 retention time at 20 mg/kg, iv administered in corn oil by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748871Drug metabolism in mouse liver microsomes assessed as formation of 2,4-dimethylhydrazine at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748850Drug metabolism in mouse liver microsomes assessed as (E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N'-(3-hydroxybenzyli-dene)acetohydrazide retention time at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748870Drug metabolism in mouse liver microsomes assessed as formation of 2,4-dimethylaniline at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748875Drug metabolism in mouse liver microsomes assessed as metabolite M4 retention time at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748867Drug metabolism in mouse plasma assessed as formation of 3-methoxy benzaldehyde at 5 uM by LC/MS/MS analysis2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
AID748855Neuroprotective activity in mouse HT22 cells assessed as reduction in glutamate-induced oxidative stress incubated for 30 mins prior to glutamate-challenge measured after 24 hrs by MTT assay2013Bioorganic & medicinal chemistry, May-15, Volume: 21, Issue:10
Metabolism of a potent neuroprotective hydrazide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (36.36)24.3611
2020's7 (63.64)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 31.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index31.09 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.76 (4.65)
Search Engine Demand Index56.46 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (31.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (18.18%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (81.82%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]