2-ethylfuran

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-ethylfuran is a heterocyclic compound with the molecular formula C6H8O. It is a colorless liquid with a characteristic odor. 2-ethylfuran is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also a potential biofuel due to its high energy density and low emissions. Research on 2-ethylfuran focuses on its synthesis, characterization, and potential applications. The compound is often studied for its potential as a renewable fuel source, as well as its potential use in the synthesis of other valuable compounds. '

2-ethylfuran: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-ethylfuran : A member of the class of furans that is furan in which the hydrogen atom at position 2 has been replaced by an ethyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	18554
CHEMBL ID	2269084
CHEBI ID	141565

Synonyms (40)

Synonym
furan, 2-ethyl-
furan, .alpha.-ethyl-
2-ethyl furan
3208-16-0
inchi=1/c6h8o/c1-2-6-4-3-5-7-6/h3-5h,2h2,1h
2-ethylfuran, >=99%
2-ethylfuran, 97%
2-ethyloxole
alpha-ethylfuran
fema no. 3673
2-ethylfuran
ccris 4387
einecs 221-714-0
E0454
CHEBI:141565
fema 3673
2-ethyl furane
AKOS005254497
t8o6j71t9o ,
unii-t8o6j71t9o
A821123
GEO-01350
FT-0612271
S10154
2-ethylfuran [fhfi]
.alpha.-ethylfuran
CHEMBL2269084
DTXSID7062906
W-106860
mfcd00003259
2-ethylfuran, analytical standard
2-ethyl-furan
alpha-ethyl-furan
Q17989420
EN300-51262
SB60988
2-ethylfuran 100 microg/ml in acetonitrile
2-ethylfuran; ?-ethylfuran; furan, 2-ethyl-
CS-W013731
Z640169748

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
fragrance	A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell.
Maillard reaction product	Any thermal degradation product obtained as a result of a chemical reaction between an amino acid and a reducing sugar (Maillard reaction, a non-enzymatic browning procedure that usually imparts flavour to starch-based food products).
bacterial metabolite	Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
furans	Compounds containing at least one furan ring.
volatile organic compound	Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID1102843	Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as growth inhibition rate at 3.64 mg/l after 72 hr by spectrophotometry	2004	Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4	Volatile constituents from the leaves of Callicarpa japonica Thunb. and their antibacterial activities.
AID1102936	Antimicrobial activity against Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028 assessed as growth inhibition rate at 3.64 mg/l after 72 hr by spectrophotometry	2004	Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4	Volatile constituents from the leaves of Callicarpa japonica Thunb. and their antibacterial activities.
AID1102812	Antimicrobial activity against Escherichia coli O157:H7 ATCC 43894 assessed as growth inhibition rate at 3.64 mg/l after 72 hr by spectrophotometry	2004	Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4	Volatile constituents from the leaves of Callicarpa japonica Thunb. and their antibacterial activities.
AID1102967	Antimicrobial activity against Bacillus cereus ATCC 11778 assessed as growth inhibition rate at 3.64 mg/l after 72 hr by spectrophotometry	2004	Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4	Volatile constituents from the leaves of Callicarpa japonica Thunb. and their antibacterial activities.
AID1102905	Antimicrobial activity against Vibrio parahaemolyticus ATCC 33844 assessed as growth inhibition rate at 3.64 mg/l after 72 hr by spectrophotometry	2004	Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4	Volatile constituents from the leaves of Callicarpa japonica Thunb. and their antibacterial activities.
AID1102874	Antimicrobial activity against Listeria monocytogenes ATCC 19111 assessed as growth inhibition rate at 3.64 mg/l after 72 hr by spectrophotometry	2004	Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4	Volatile constituents from the leaves of Callicarpa japonica Thunb. and their antibacterial activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	2 (40.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	27.86 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.97 (4.65)
Search Engine Demand Index	29.35 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (27.86)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetaldehyde Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.	2.02	1	aldehyde	carcinogenic agent; EC 3.5.1.4 (amidase) inhibitor; electron acceptor; Escherichia coli metabolite; human metabolite; mouse metabolite; mutagen; oxidising agent; Saccharomyces cerevisiae metabolite; teratogenic agent
1-propanol 1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.. propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.	2.02	1	propan-1-ols; short-chain primary fatty alcohol	metabolite; protic solvent
toluene methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.	2.02	1	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent
n-hexanal [no description available]	2.02	1	medium-chain fatty aldehyde; n-alkanal; saturated fatty aldehyde	human urinary metabolite
linalool linalool: RN given refers to parent cpd without isomeric designation; structure. linalool : A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.	2.02	1	monoterpenoid; tertiary alcohol	antimicrobial agent; fragrance; plant metabolite; volatile oil component
furfuryl alcohol furfuryl alcohol: structure. furfuryl alcohol : A furan bearing a hydroxymethyl substituent at the 2-position.	2.17	1	furans; primary alcohol	Maillard reaction product
furaldehyde Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.	2.11	1	aldehyde; furans	Maillard reaction product; metabolite
pentanal pentanal : A saturated fatty aldehyde composed from five carbons in a straight chain.	2.02	1	saturated fatty aldehyde	plant metabolite
1-hexanol 1-hexanol: RN given refers to parent cpd. hexanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of six carbon atoms.. hexan-1-ol : A primary alcohol that is hexane substituted by a hydroxy group at position 1.	2.02	1	hexanol; primary alcohol	alarm pheromone; antibacterial agent; fragrance; plant metabolite
ethyl acetate ethyl acetate : The acetate ester formed between acetic acid and ethanol.	2.02	1	acetate ester; ethyl ester; volatile organic compound	EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor; metabolite; polar aprotic solvent; Saccharomyces cerevisiae metabolite
2-methylfuran 2-methylfuran : A member of the class of furans that is furan in which the hydrogen at position 2 is replaced by a methyl group.	2.17	1	furans; volatile organic compound	flavouring agent; fuel; hepatotoxic agent; human urinary metabolite; plant metabolite
2,3-pentanedione pentane-2,3-dione : An alpha-diketone that is pentane substituted at the 2- and 3-positions by oxo groups.	2.02	1	alpha-diketone; methyl ketone	flavouring agent
1-penten-3-ol [no description available]	2.02	1	alcohol
2,5-dimethylfuran 2,5-dimethylfuran: metabolite of n-hexane. 2,5-dimethylfuran : A member of the class of furans that is furan in which the hydrogens at positions 2 and 5 are replaced by methyl groups.	7.31	1	furans	antifungal agent; bacterial metabolite; fuel; fumigant; human urinary metabolite; Maillard reaction product; plant metabolite
2-acetylfuran 2-acetylfuran : A furan carrying an acetyl substituent at the 2-position. Used in the production of the antibiotic cefuroxime (CHEBI:3515).	7.54	2	aromatic ketone; furans; methyl ketone
2-pentylfuran 2-pentylfuran: structure in first source. 2-pentylfuran : A member of the class of furans that is furan in which the hydrogen at position 2 is replaced by a pentyl group. It is found in many heat-processed foods and drinks.	2.17	1	furans	Aspergillus metabolite; bacterial metabolite; flavouring agent; human urinary metabolite; insect repellent; plant growth stimulator; volatile oil component
3-octanone 3-octanone : A dialkyl ketone that is octane in which the two methylene protons at position 3 have been replaced by an oxo group.	2.02	1	dialkyl ketone	antifeedant; biomarker; fungal metabolite; human urinary metabolite; insect attractant; plant metabolite; toxin
(+)-delta-cadinene delta-cadinene: has antineoplastic activity; structure in first source. delta-cadinene : A member of the cadinene family of sesquiterpenes in which the double bonds are located at the 4-4a and 7-8 positions, and in which the isopropyl group at position 1 is cis to the hydrogen at the adjacent bridgehead carbon (position 8a).. (+)-delta-cadinene : A member of the cadinene family of sesquiterpenes in which the double bonds are located at the 4-4a and 7-8 positions, and in which the isopropyl group at position 1 is cis to the hydrogen at the adjacent bridgehead carbon (the 1S,8aR-enantiomer).	2.02	1	cadinene; delta-cadinene
2,4-hexadienal 2,4-hexadienal: RN given refers to compound with no isomeric designation. hexadienal : An enal that is hexadiene carrying an oxo group at position 1.. (E,E)-2,4-hexadienal : A hexadienal that is hexanal with trans double bonds at positions 2 and 4. It is found in tomatoes, kiwi fruit, mangoes, potato chips, herbs and spices.	2.02	1	hexadienal; polyunsaturated fatty aldehyde; volatile organic compound	flavouring agent; plant metabolite
2-hexenal, z-isomer 2-hexenal: product of lipid peroxidation in the rat liver; a green odor chemical; do not confuse with the hexabarbital synonym, hexenal; RN given refers to cpd without isomeric designation. 2-hexenal : A hexenal having the double bond at the 2-position.. (2E)-hexenal : A 2-hexenal in which the olefinic double bond has E configuration. It occurs naturally in a wide range of fruits, vegetables, and spices.	2.02	1	2-hexenal	antibacterial agent; flavouring agent; plant metabolite
humulene humulene: structure given in first source. (1E,4E,8E)-alpha-humulene : The (1E,4E,8E)-isomer of alpha-humulene.	2.02	1	alpha-humulene
2,4-heptadienal 2,4-heptadienal: structure in first source. (E,E)-hepta-2,4-dienal : A heptadienal in which the two double bonds are located at positions 2 and 4 (the E,E-geoisomer).	2.02	1	heptadienal	flavouring agent
2-pentenal 2-pentenal: RN given refers to cpd without isomeric designation. 2-pentenal : An enal consisting of pent-2-ene having an oxo group at the 1-position. (E)-2-pentenal : A 2-pentenal in which the double bond has (E)-configuration. It is found in cigarette smoke, virgin olive oil, and milk.	2.02	1	2-pentenal	plant metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.31	1	0

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