2-acetylfuran

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-acetylfuran : A furan carrying an acetyl substituent at the 2-position. Used in the production of the antibiotic cefuroxime (CHEBI:3515). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	14505
CHEBI ID	59983
SCHEMBL ID	43960
MeSH ID	M0118625

Synonyms (79)

Synonym
1-furan-2-yl-ethanone
2-furyl methyl ketone
2-acetylfuran
ketone, 2-furyl methyl
acetylfuran
ethanone, 1-(2-furanyl)-
1192-62-7
nsc-4665
methyl 2-furyl ketone
nsc4665
nsc49133
nsc-49133
ai3-23586
einecs 214-757-1
furan, 2-acetyl-
1-(2-furanyl)ethanone
ccris 3161
nsc 49133
nsc 4665
fema no. 3163
2-furylethanone
2-furyl methyl ketone (natural)
brn 0107909
1-(2-furyl)ethanone
inchi=1/c6h6o2/c1-5(7)6-3-2-4-8-6/h2-4h,1h
2-furyl methyl ketone, 99%
2-furyl methyl ketone, >=99%, fg
1-(furan-2-yl)ethanone
STK400329
AC-11853
A0091
furyl methyl ketone
(2-furanyl)-1-ethanone
1-(2-furanyl)-ethanone
CHEBI:59983 ,
AKOS000119584
1-(2-furyl)ethanone;2-acetylfuran
A804234
1-(furan-2-yl)-ethanone
2-acetyl furan
unii-q5zrp80k02
q5zrp80k02 ,
5-17-09-00381 (beilstein handbook reference)
FT-0610977
PS-4586
AM91073
EPITOPE ID:136039
1-(furan-2-yl)ethan-1-one
SCHEMBL43960
2-acetylfuran [fhfi]
2-furyl methyl ketone [fcc]
methyl-2-furyl ketone
acetyl furan
2-acetyl-furan
2-acetylfurane
DTXSID0051601
1-(2-furyl)ethanone #
STR05504
80145-44-4
Q-100089
mfcd00003242
ethanone, 1-(furanyl)-
F0001-0316
2-furyl methyl ketone, purum, >=99.0% (gc)
2-furyl methyl ketone, analytical standard
2-furyl methyl ketone, natural (us), >=97%, fg
2-acetylfuran; 1-(2-furyl)ethanone
2-acetofurone
a-furyl methyl ketone
1-(2-furanyl)-ethanone (2-acetylfuran)
fema 3163
1-(2-furanyl)ethanone (acetylfuran)
1-(2-furanyl)ethanone, 9ci
CS-W016628
Q15634156
SB60920
EN300-20230
HY-W015912
PD158331

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

Class	Description
furans	Compounds containing at least one furan ring.
methyl ketone	A ketone of formula RC(=O)CH3 (R =/= H).
aromatic ketone	A ketone in which the carbonyl group is attached to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (6.67)	18.7374
1990's	3 (20.00)	18.2507
2000's	2 (13.33)	29.6817
2010's	5 (33.33)	24.3611
2020's	4 (26.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 41.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	41.49 (24.57)
Research Supply Index	2.83 (2.92)
Research Growth Index	5.21 (4.65)
Search Engine Demand Index	55.05 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (41.49)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	6.93	1	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	2.03	1	metal allergen; nickel group element atom	epitope; micronutrient
furfuryl alcohol furfuryl alcohol: structure. furfuryl alcohol : A furan bearing a hydroxymethyl substituent at the 2-position.	2.17	1	furans; primary alcohol	Maillard reaction product
furaldehyde Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.	3.44	7	aldehyde; furans	Maillard reaction product; metabolite
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	2.38	2	alkane
furan furan : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid.	6.93	1	furans; mancude organic heteromonocyclic parent; monocyclic heteroarene	carcinogenic agent; hepatotoxic agent; Maillard reaction product
2,5-hexanedione 2,5-hexanedione: metabolite of methyl-n-butyl ketone. 2,5-hexanedione : A diketone that is hexane substituted by oxo groups at positions 2 and 5. It is a toxic metabolite of hexane and of 2-hexanone	7.38	2	diketone; methyl ketone	human xenobiotic metabolite; neurotoxin
n-hexane hexane : An unbranched alkane containing six carbon atoms.	7.38	2	alkane; volatile organic compound	neurotoxin; non-polar solvent
isoxazoles Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.	6.98	1	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
2-methylfuran 2-methylfuran : A member of the class of furans that is furan in which the hydrogen at position 2 is replaced by a methyl group.	2.17	1	furans; volatile organic compound	flavouring agent; fuel; hepatotoxic agent; human urinary metabolite; plant metabolite
5-methyl-2-furfural 5-methyl-2-furfural: RN given refers to cpd with locants as specified	3.07	3	aldehyde; furans	EC 2.2.1.6 (acetolactate synthase) inhibitor; flavouring agent; human metabolite; Maillard reaction product
2-ethylfuran 2-ethylfuran: structure in first source. 2-ethylfuran : A member of the class of furans that is furan in which the hydrogen atom at position 2 has been replaced by an ethyl group.	7.54	2	furans; volatile organic compound	bacterial metabolite; fragrance; Maillard reaction product; plant metabolite
2-pentylfuran 2-pentylfuran: structure in first source. 2-pentylfuran : A member of the class of furans that is furan in which the hydrogen at position 2 is replaced by a pentyl group. It is found in many heat-processed foods and drinks.	2.17	1	furans	Aspergillus metabolite; bacterial metabolite; flavouring agent; human urinary metabolite; insect repellent; plant growth stimulator; volatile oil component
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	2.1	1	N-acetyl-D-glucosamine	epitope
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.08	1	D-glucopyranose	epitope; mouse metabolite
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	2.03	1	cobalt group element atom; metal allergen	micronutrient
lignin Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed). lignin : A polyphenylpropanoid derived from three monolignol monomers: trans-p-coumaryl alcohol, coniferol and trans-sinapyl alcohol. There is extensive cross-linking and no defined primary structure.	2.41	1
5-hydroxymethylfurfural 5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.	2.87	3	arenecarbaldehyde; furans; primary alcohol	indicator; Maillard reaction product
mannich bases Mannich Bases: Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.	6.93	1
ribose ribopyranose : The pyranose form of ribose.	7.04	1	D-ribose; ribopyranose

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