quinuronium sulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

quinuronium sulfate: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	8661
MeSH ID	M0053612

Synonyms (32)

Synonym
pirevan
zothelone
urea, 1,3-diquinolin-6-yl-, bismethosulfate
6,6'-ureylenebis(1-methylquinolinium)bis(methosulfate)
quinuronium sulfate
sn 5,870
1,1'-dimethyl-6,6'-ureylenediquinolinium dimethyl bis(sulphate)
pyroplasmin
1,3-diquinolin-6-ylurea bismethosulfate
6,6'-ureylenebis(1,1'-dimethylquinolinium) sulfate
baburan
dimethylquinolyl methylsulfate urea
acaprin
atral
quinolinium, 6,6'-ureylenebis(1,1'-dimethyl-, sulfate (1:2)
einecs 205-179-0
135-14-8
quinolinium, 6,6'-(carbonyldiimino)bis(1-methyl-, bis(methyl sulfate)
de4g9v3o4a ,
unii-de4g9v3o4a
quinuroium methylsulfate
1,3-di-6-quinolylurea bismethosulfate
pirozoo
diveronal
quinuronium sulphate
quinuronium methylsulfate
sn-5870
1,3-di-6-quinolylurea bismethosulfate [mi]
acapron
1,3-bis(1-methylquinolin-1-ium-6-yl)urea;methyl sulfate
Q27276341
DTXSID001033866

Research Excerpts

Toxicity

Excerpt	Reference	Relevance
" This study indicates that quinuronium is highly toxic and that rabbits are moderately resistant."	( Acute toxicity studies with quinuronium sulfate in laboratory animals and sheep. Maribei, JM; Mitema, ES; Nafstad, I, 1984)	0.56

Dosage Studied

Excerpt	Relevance	Reference
" Each animal was dosed 30 min."	( Effects of quinuronium sulfate pre-exposure on hepatic excretion of sulfobromophthalein (BSP) as measured by isolated perfused rat liver. Frøslie, A; Mitema, ES; Nafstad, I, 1983)	0.66
" The recommended dosage is 0,5 mg/kg body mass of primaquine base."	( Chemotherapy of Babesia felis infection: efficacy of certain drugs. Potgieter, FT, 1981)	0.26

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (18)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	15 (83.33)	18.7374
1990's	3 (16.67)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.37 (24.57)
Research Supply Index	3.00 (2.92)
Research Growth Index	4.29 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.37)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (5.56%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (94.44%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	5.6	18	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
diminazene Diminazene: An effective trypanocidal agent.. diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group.	8.07	5	0	carboxamidine; triazene derivative	antiparasitic agent; trypanocidal drug
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	1.96	1	0	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
primaquine Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404). primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.	2.37	2	0	aminoquinoline; aromatic ether; N-substituted diamine	antimalarial
sulfamethoxypyridazine Sulfamethoxypyridazine: A sulfanilamide antibacterial agent.. sulfamethoxypyridazine : A sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position.	1.97	1	0	pyridazines; sulfonamide antibiotic; sulfonamide	antiinfective agent; drug allergen; EC 2.5.1.15 (dihydropteroate synthase) inhibitor
sulfobromophthalein Sulfobromophthalein: A phenolphthalein that is used as a diagnostic aid in hepatic function determination.	6.96	1	0	2-benzofurans; organobromine compound; organosulfonic acid; phenols	dye
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	1.97	1	0	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
trimethoprim Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.	1.97	1	0	aminopyrimidine; methoxybenzenes	antibacterial drug; diuretic; drug allergen; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; environmental contaminant; xenobiotic
imidocarb Imidocarb: One of ANTIPROTOZOAL AGENTS used especially against BABESIA in livestock. Toxicity has been reported.	4.45	5	1	ureas	antiprotozoal drug
bilirubin [no description available]	1.96	1	0	biladienes; dicarboxylic acid	antioxidant; human metabolite; mouse metabolite
diminazene aceturate diminazene diaceturate : An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine.	2.66	3	0	N-acetylglycinate salt	antiparasitic agent; trypanocidal drug
imidocarb dipropionate [no description available]	2.37	2	0
amicarbalide diisethionate amicarbalide diisethionate: structure	2.88	4	0
oxytetracycline, anhydrous Oxytetracycline: A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES RIMOSUS and used in a wide variety of clinical conditions.. oxytetracycline : A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.	1.98	1	0
tetrocarcin a tetrocarcin A: from cultures of strain No. T-90 designated as Micromonospora chalcea subsp. kazunoensis	1.97	1	0

Condition	Relationship Strength	Studies	Trials
Babesia Infection [description not available]	4.96	9	1
Bovine Diseases [description not available]	2.37	2	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.37	2	0
Ovine Diseases [description not available]	3.34	1	1
Cat Diseases Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.	1.96	1	0
Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus.	1.99	1	0
Corridor Disease [description not available]	1.97	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.96	1	0
Ataxia Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.	1.96	1	0
Action Tremor [description not available]	1.96	1	0
Tremor Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.	1.96	1	0

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