Target type: molecularfunction
Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). [GOC:ai, GOC:bf, Wikipedia:Somatostatin]
| Protein | Definition | Taxonomy |
|---|---|---|
| Somatostatin receptor type 4 | A somatostatin receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P31391] | Homo sapiens (human) |
| Somatostatin receptor type 5 | A somatostatin receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35346] | Homo sapiens (human) |
| Somatostatin receptor type 2 | A somatostatin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30874] | Homo sapiens (human) |
| Somatostatin receptor type 3 | A somatostatin receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32745] | Homo sapiens (human) |
| Somatostatin receptor type 1 | A somatostatin receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30872] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| astemizole | astemizole : A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position. Astemizole: Antihistamine drug now withdrawn from the market in many countries because of rare but potentially fatal side effects. | benzimidazoles; piperidines | anti-allergic agent; anticoronaviral agent; H1-receptor antagonist |
| camptothecin | NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source | delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol | antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite |
| edotreotide | Edotreotide: DOTA - 1,4,7,10-tetraazacyclododecanetetracetic acid; structure given in first source; may be labelled with various radioisotopes | ||
| octreotide | |||
| l803087 | L-803087 : A fluoroindole that is 1H-indole substituted by phenyl, 4-{[(2S)-5-carbamimidamido-1-methoxy-1-oxopentan-2-yl]amino}-4-oxobutyl, fluoro and fluoro groups at positions 2, 3, 5 and 7, respectively. It is a selective nonpeptidic agonist of the somatostatin subtype-4 (SST4) receptor with Ki of 0.7 nM. L803087: structure in first source | benzenes; fluoroindole; guanidines; L-arginine derivative; methyl ester; phenylindole; secondary carboxamide | somatostatin receptor agonist |
| obelin | obelin: calcium-sensitive photoprotein obtained from the hydroid Obelia geniculata | ||
| seglitide | seglitide: more potent than somatostatin for inhibition of insulin, glucagon & growth hormone release; used experimentally in treatment of Alzheimer's disease; somatostatin receptor antagonist | ||
| lanreotide | |||
| nnc 26-9100 | NNC 26-9100: structure in first source | aminopyridine | |
| l 363301 | |||
| pasireotide | pasireotide : A six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease. | homodetic cyclic peptide; peptide hormone | antineoplastic agent |
| naluzotan | naluzotan: an antidepressant and anti-anxiety agent; structure in first source | ||
| (1's, 2s)-4-amino-n-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide | (1'S, 2S)-4-amino-N-(1'-carbamoyl-2'-phenylethyl)-2-(4''-methyl-1''-naphthalenesulfonylamino)butanamide: a somatostatin receptor 4 agonist; structure in first source | ||
| l 054522 | L 054522: somatostatin receptor subtype 2 agonist; structure in first source | ||
| somatostatin | heterodetic cyclic peptide; peptide hormone | ||
| prosomatostatin | heterodetic cyclic peptide; peptide hormone | fungal metabolite; mouse metabolite; rat metabolite |